microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4301 Gene

Data sources for MIR4301 Gene:

Subcategory (RNA class) for MIR4301 Gene

miRNA

Aliases for MIR4301 Gene

External Ids for MIR4301 Gene

Previous GeneCards Identifiers for MIR4301 Gene

  • GC11U901717
  • GC11M113320

Summaries for MIR4301 Gene

Entrez Gene Summary for MIR4301 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4301 Gene

MIR4301 (MicroRNA 4301) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4301 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4301 Gene

Genomics for MIR4301 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4301 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J113445 Enhancer 0.9 Ensembl ENCODE 0.7 +2.8 2763 3.2 IRF4 GABPA FOSL1 ATF1 BATF INSM2 ZNF189 ZBTB21 JUNB USF2 DRD2 MIR4301 lnc-TMPRSS5-2 HSALNG0087250 ANKK1
GH11J113474 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 0.3 -24.9 -24913 1.2 ZBTB10 ZIC2 ZNF610 THAP11 SIN3A ZNF395 REST VEZF1 ZNF341 ZSCAN9 DRD2 HSALNG0087250 HSALNG0087251 MIR4301 LOC105369501 ANKK1
GH11J113457 Enhancer 0.6 Ensembl ENCODE 0.4 -7.7 -7713 1.6 ZIC2 ZNF341 GLIS1 ENSG00000256757 ENSG00000255129 TTC12 DRD2 MIR4301 HSALNG0087250 ANKK1
GH11J113429 Enhancer 0.5 Ensembl 0.4 +19.9 19863 1.2 TAL1 HDAC2 TCF12 ARID1B CBFA2T2 KDM1A TRIM24 NCOR1 CBFA2T3 TTC12 lnc-TMPRSS5-2 MIR4301 ANKK1 DRD2 HSALNG0087250
GH11J113467 Promoter 0.4 EPDnew 0.4 -17.5 -17472 0.1 MNT DRD2 HSALNG0087250 MIR4301 ANKK1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4301 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4301 Gene

Latest Assembly
chr11:113,450,023-113,450,088
(GRCh38/hg38)
Size:
66 bases
Orientation:
Minus strand

Previous Assembly
chr11:113,320,745-113,320,810
(GRCh37/hg19 by Entrez Gene)
Size:
66 bases
Orientation:
Minus strand

chr11:113,320,745-113,320,810
(GRCh37/hg19 by Ensembl)
Size:
66 bases
Orientation:
Minus strand

Genomic View for MIR4301 Gene

Genes around MIR4301 on UCSC Golden Path with GeneCards custom track
MIR4301 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR4301 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4301 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4301 Gene

Proteins for MIR4301 Gene

Post-translational modifications for MIR4301 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4301 Gene

Domains & Families for MIR4301 Gene

Gene Families for MIR4301 Gene

HGNC:
genes like me logo Genes that share domains with MIR4301: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4301 Gene

Function for MIR4301 Gene

Phenotypes From GWAS Catalog for MIR4301 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4301 Gene

Localization for MIR4301 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4301 Gene

Pathways & Interactions for MIR4301 Gene

PathCards logo

SuperPathways for MIR4301 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4301 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4301 Gene

Drugs & Compounds for MIR4301 Gene

No Compound Related Data Available

Transcripts for MIR4301 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4301 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075DDFA_9606 miRNA 20 4

RefSeq: NR_036183,

LncBase: hsa-miR-4301,

miRBase: MIMAT0016850,

TarBase: hsa-miR-4301,

URS000075A09B_9606 pre_miRNA 66 3

RefSeq: NR_036183,

Ensembl: ENST00000577203 (view in UCSC) ,

miRBase: MI0015828,

MIR4301 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4301 Gene

No ASD Table

Relevant External Links for MIR4301 Gene

GeneLoc Exon Structure for
MIR4301

No data available for mRNA/cDNA for MIR4301 Gene

Expression for MIR4301 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR4301

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4301 Gene

Orthologs for MIR4301 Gene

Evolution for MIR4301 Gene

ENSEMBL:
Gene Tree for MIR4301 (if available)
TreeFam:
Gene Tree for MIR4301 (if available)

No data available for Orthologs for MIR4301 Gene

Paralogs for MIR4301 Gene

No data available for Paralogs for MIR4301 Gene

Variants for MIR4301 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR4301 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR4301 Gene

Variant ID Type Subtype PubMed ID
nsv556444 CNV gain 21841781

Additional Variant Information for MIR4301 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4301

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4301 Gene

Disorders for MIR4301 Gene

Additional Disease Information for MIR4301

No disorders were found for MIR4301 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4301 Gene

Publications for MIR4301 Gene

  1. LncRNA LACAT1 promotes proliferation of oral squamous cell carcinoma cells by inhibiting microRNA-4301. (PMID: 30964168) Wang J … Xu YY (European review for medical and pharmacological sciences 2019) 3
  2. A novel report of MiR-4301 induces cell apoptosis by negatively regulating DRD2 expression in human breast cancer cells. (PMID: 29236292) Gholipour N … Ahangari G (Journal of cellular biochemistry 2018) 3
  3. Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease. (PMID: 24058526) Bhatnagar P … Arking DE (PloS one 2013) 3
  4. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff LA … Hart RP (PloS one 2009) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4301 Gene

Sources for MIR4301 Gene