microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4299 Gene

Subcategory (RNA class) for MIR4299 Gene

miRNA

Number of RNA Genes sources:

1 / 17

Aliases for MIR4299 Gene

  • MicroRNA 4299 2 3 5
  • Hsa-Mir-4299 2 3
  • MIR4299 2 5
  • MIMAT0016851 50
  • MI0015829 50

External Ids for MIR4299 Gene

Previous GeneCards Identifiers for MIR4299 Gene

  • GC11U901740

Summaries for MIR4299 Gene

Entrez Gene Summary for MIR4299 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4299 Gene

MIR4299 (MicroRNA 4299) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4299 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4299 Gene

Genomics for MIR4299 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4299 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J011657 Enhancer 0.3 Ensembl ENCODE 600.7 -0.8 -790 0.6 MIR4299 GALNT18 piR-55194-062 USP47
GH11J011659 Enhancer 0.6 Ensembl 0.7 -4.4 -4440 3.3 CTCF IKZF2 SCRT2 RELA RELB ZNF10 ELF1 POLR2A SMARCA4 MTA2 GALNT18 MIR4299 piR-55194-062 USP47
GH11J011691 Enhancer 0.8 Ensembl ENCODE CraniofacialAtlas 0.3 -35.3 -35251 1.1 SOX13 YY1 POLR2A NR2F1 NR2F6 TAF1 piR-55194-062 MIR4299 GALNT18 USP47
GH11J011668 Enhancer 0.4 Ensembl 0.4 -12.6 -12579 1.4 ZIC2 GATA3 FEZF1 GATA2 GALNT18 ENSG00000255462 USP47 MIR4299 piR-55194-062
GH11J011671 Enhancer 0.3 Ensembl 0.4 -15.5 -15479 0.8 TEAD4 GALNT18 ENSG00000255462 MIR4299 piR-55194-062 USP47
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4299 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4299 Gene

Genomic Locations for MIR4299 Gene
chr11:11,656,651-11,656,722
(GRCh38/hg38)
Size:
72 bases
Orientation:
Minus strand
chr11:11,678,198-11,678,269
(GRCh37/hg19)
Size:
72 bases
Orientation:
Minus strand

Genomic View for MIR4299 Gene

Genes around MIR4299 on UCSC Golden Path with GeneCards custom track
MIR4299 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4299 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4299 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4299 Gene

Proteins for MIR4299 Gene

Post-translational modifications for MIR4299 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4299 Gene

Domains & Families for MIR4299 Gene

Gene Families for MIR4299 Gene

HGNC:
genes like me logo Genes that share domains with MIR4299: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4299 Gene

Function for MIR4299 Gene

Phenotypes From GWAS Catalog for MIR4299 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4299 Gene

Localization for MIR4299 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4299 Gene

Pathways & Interactions for MIR4299 Gene

PathCards logo

SuperPathways for MIR4299 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4299 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4299 Gene

Drugs & Compounds for MIR4299 Gene

No Compound Related Data Available

Transcripts for MIR4299 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4299 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075EC98_9606 precursor_RNA 72 4

HGNC: 38329,

RefSeq: NR_036184,

Ensembl: ENST00000577899 (view in UCSC) ,

miRBase: MI0015829,

URS000075ED80_9606 miRNA 18 2

RefSeq: NR_036184,

miRBase: MIMAT0016851,

MIR4299 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4299 Gene

No ASD Table

Relevant External Links for MIR4299 Gene

GeneLoc Exon Structure for
MIR4299

No data available for mRNA/cDNA for MIR4299 Gene

Expression for MIR4299 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4299 Gene

Orthologs for MIR4299 Gene

Evolution for MIR4299 Gene

ENSEMBL:
Gene Tree for MIR4299 (if available)
TreeFam:
Gene Tree for MIR4299 (if available)

No data available for Orthologs for MIR4299 Gene

Paralogs for MIR4299 Gene

No data available for Paralogs for MIR4299 Gene

Variants for MIR4299 Gene

Additional dbSNP identifiers (rs#s) for MIR4299 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4299 Gene

Variant ID Type Subtype PubMed ID
nsv483000 CNV loss 15286789

Additional Variant Information for MIR4299 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4299

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4299 Gene

Disorders for MIR4299 Gene

No disorders were found for MIR4299 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4299 Gene

Publications for MIR4299 Gene

  1. MiR-4299 suppresses non-small cell lung cancer cell proliferation, migration and invasion through modulating PTEN/AKT/PI3K pathway. (PMID: 29917192) Yang WB … Wang JW (European review for medical and pharmacological sciences 2018) 3
  2. miR-4299 mediates the invasive properties and tumorigenicity of human follicular thyroid carcinoma by targeting ST6GALNAC4. (PMID: 26715099) Miao X … Zhao Y (IUBMB life 2016) 3
  3. Specific microRNAs as novel biomarkers for combination chemotherapy resistance detection of colon adenocarcinoma. (PMID: 26626874) Hu J … Cai S (European journal of medical research 2015) 3
  4. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff LA … Hart RP (PloS one 2009) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4299 Gene

Sources for MIR4299 Gene