microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4295 Gene

Subcategory (RNA class) for MIR4295 Gene

miRNA

Number of RNA Genes sources:

1 / 14

Aliases for MIR4295 Gene

  • MicroRNA 4295 2 3 5
  • Hsa-Mir-4295 3
  • MIMAT0016844 51
  • MI0015822 51
  • MIR4295 2

External Ids for MIR4295 Gene

Previous GeneCards Identifiers for MIR4295 Gene

  • GC10U901342
  • GC10P114393

Summaries for MIR4295 Gene

Entrez Gene Summary for MIR4295 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4295 Gene

MIR4295 (MicroRNA 4295) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4295 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4295 Gene

Genomics for MIR4295 Gene

GeneHancer (GH) Regulatory Elements for MIR4295 Gene

Promoters and enhancers for MIR4295 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J112633 Enhancer 0.7 Ensembl ENCODE 500.7 +0.1 131 2.2 JUND FOS PBX2 ZNF843 FEZF1 MEIS2 PKNOX1 ZSCAN4 ZNF600 MIR4295 lnc-ACSL5-2 lnc-ZDHHC6-7 ENSG00000233340 VTI1A
GH10J112631 Enhancer 1.1 Ensembl ENCODE 0.7 -2.3 -2256 1.8 NCOR1 KDM6A ZBTB25 SMARCC2 SKI TEAD1 ZBTB26 TBX3 ZKSCAN8 KLF9 ENSG00000233340 MIR4295 ENSG00000234017 lnc-ZDHHC6-5 VTI1A
GH10J112562 Enhancer 1.4 UCNEbase Ensembl ENCODE 0.2 -70.3 -70269 2.2 FOXK2 TCF12 NCOR1 KDM6A TCF7 FOXA1 TRIM28 TGIF2 SKI TEAD1 lnc-ZDHHC6-5 ENSG00000234017 MIR4295 VTI1A
GH10J112584 Enhancer 0.8 Ensembl ENCODE 0.3 -48.0 -47969 6.4 JUND TEAD4 EP300 OSR2 FOS FOSL2 CEBPB JUN NR3C1 SCRT1 HABP2 lnc-ZDHHC6-5 ENSG00000234017 MIR4295 VTI1A
GH10J112565 Enhancer 0.7 ENCODE 0.2 -68.5 -68513 0.2 CTCF ZSCAN5C RAD21 DEK FOXA2 SMC3 ZNF184 KDM5A CEBPG DRAP1 lnc-ZDHHC6-5 ENSG00000234017 MIR4295 VTI1A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4295 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4295 Gene

Genomic Locations for MIR4295 Gene
chr10:112,634,170-112,634,254
(GRCh38/hg38)
Size:
85 bases
Orientation:
Plus strand
chr10:114,393,929-114,394,013
(GRCh37/hg19)
Size:
85 bases
Orientation:
Plus strand

Genomic View for MIR4295 Gene

Genes around MIR4295 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4295 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4295 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4295 Gene

Proteins for MIR4295 Gene

Post-translational modifications for MIR4295 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4295 Gene

Domains & Families for MIR4295 Gene

Gene Families for MIR4295 Gene

HGNC:
genes like me logo Genes that share domains with MIR4295: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4295 Gene

Function for MIR4295 Gene

Phenotypes From GWAS Catalog for MIR4295 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4295 Gene

Localization for MIR4295 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4295 Gene

Pathways & Interactions for MIR4295 Gene

PathCards logo

SuperPathways for MIR4295 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR4295 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4295 Gene

Drugs & Compounds for MIR4295 Gene

No Compound Related Data Available

Transcripts for MIR4295 Gene

mRNA/cDNA for MIR4295 Gene

2 RNACentral transcripts :
1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 miRBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4295 Gene

No ASD Table

Relevant External Links for MIR4295 Gene

GeneLoc Exon Structure for
MIR4295

Expression for MIR4295 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4295 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR4295

genes like me logo Genes that share expression patterns with MIR4295: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4295 Gene

Orthologs for MIR4295 Gene

Evolution for MIR4295 Gene

ENSEMBL:
Gene Tree for MIR4295 (if available)
TreeFam:
Gene Tree for MIR4295 (if available)

No data available for Orthologs for MIR4295 Gene

Paralogs for MIR4295 Gene

No data available for Paralogs for MIR4295 Gene

Variants for MIR4295 Gene

Additional dbSNP identifiers (rs#s) for MIR4295 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4295 Gene

Variant ID Type Subtype PubMed ID
nsv510234 OTHER sequence alteration 20534489
nsv7211 OTHER inversion 18451855

Additional Variant Information for MIR4295 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4295

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4295 Gene

Disorders for MIR4295 Gene

Additional Disease Information for MIR4295

No disorders were found for MIR4295 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4295 Gene

Publications for MIR4295 Gene

  1. Lycium barbarum polysaccharides alleviate hydrogen peroxide-induced injury by up-regulation of miR-4295 in human trabecular meshwork cells. (PMID: 30594603) Liu Y … Zhang Y (Experimental and molecular pathology 2019) 3 54
  2. Ginsenoside Rh2 inhibits prostate cancer cell growth through suppression of microRNA-4295 that activates CDKN1A. (PMID: 29457293) Gao Q … Zheng J (Cell proliferation 2018) 3 54
  3. High expression of microRNA-4295 contributes to cell proliferation and invasion of pancreatic ductal adenocarcinoma by the down-regulation of Glypican-5. (PMID: 29407175) Yuan Q … Yang W (Biochemical and biophysical research communications 2018) 3 54
  4. RUNX3 is down-regulated in glioma by Myc-regulated miR-4295. (PMID: 26756701) Li X … Liu Y (Journal of cellular and molecular medicine 2016) 3 54
  5. XIAP RING domain mediates miR-4295 expression and subsequently inhibiting p63α protein translation and promoting transformation of bladder epithelial cells. (PMID: 27447744) Jin H … Huang C (Oncotarget 2016) 3 54

Products for MIR4295 Gene

Sources for MIR4295 Gene