microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4293 Gene

Subcategory (RNA class) for MIR4293 Gene

miRNA

Number of RNA Genes sources:

1 / 17

Aliases for MIR4293 Gene

  • MicroRNA 4293 2 3 5
  • Hsa-Mir-4293 2 3
  • MIR4293 2 5
  • MIMAT0016848 50
  • MI0015826 50

External Ids for MIR4293 Gene

Previous GeneCards Identifiers for MIR4293 Gene

  • GC10U901347

Summaries for MIR4293 Gene

Entrez Gene Summary for MIR4293 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4293 Gene

MIR4293 (MicroRNA 4293) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4293 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4293 Gene

Genomics for MIR4293 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4293 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J014381 Enhancer 1.1 Ensembl ENCODE dbSUPER 600.7 -0.9 -882 6.2 RELA ZIC2 ZSCAN4 TCF12 IKZF2 SP1 DPF2 RELB JUND CEBPB MIR4293 MIR1265 ENSG00000278100 FRMD4A ENSG00000282246
GH10J014378 Enhancer 0.6 Ensembl dbSUPER 0.7 +4.5 4476 0.4 NR2C2 ZBTB11 GABPA HLF USF2 NR2C1 MIR4293 ENSG00000285671 FRMD4A ENSG00000282246
GH10J014379 Enhancer 0.5 Ensembl dbSUPER 0.7 +3.6 3577 1 NR2C2 ZBTB11 MIR4293 ENSG00000285671 FRMD4A ENSG00000282246
GH10J014375 Enhancer 0.6 FANTOM5 0.4 +8.0 7997 0.3 ATF7 PRDM1 CEBPB GABPA PCBP1 CEBPG ATF4 ATF3 ENSG00000285671 MIR4293 FRMD4A ENSG00000282246
GH10J014380 Enhancer 0.2 ENCODE 0.7 +2.4 2380 0.2 MIR4293 ENSG00000285671 FRMD4A ENSG00000282246
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4293 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4293 Gene

Genomic Locations for MIR4293 Gene
chr10:14,383,200-14,383,277
(GRCh38/hg38)
Size:
78 bases
Orientation:
Minus strand
chr10:14,425,199-14,425,276
(GRCh37/hg19)
Size:
78 bases
Orientation:
Minus strand

Genomic View for MIR4293 Gene

Genes around MIR4293 on UCSC Golden Path with GeneCards custom track
MIR4293 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4293 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4293 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4293 Gene

Proteins for MIR4293 Gene

Post-translational modifications for MIR4293 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4293 Gene

Domains & Families for MIR4293 Gene

Gene Families for MIR4293 Gene

HGNC:
genes like me logo Genes that share domains with MIR4293: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4293 Gene

Function for MIR4293 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4293 Gene

Localization for MIR4293 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4293 Gene

Pathways & Interactions for MIR4293 Gene

PathCards logo

SuperPathways for MIR4293 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4293 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4293 Gene

Drugs & Compounds for MIR4293 Gene

No Compound Related Data Available

Transcripts for MIR4293 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4293 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075C2F1_9606 precursor_RNA 78 4

HGNC: 38270,

RefSeq: NR_036181,

Ensembl: ENST00000584305 (view in UCSC) ,

miRBase: MI0015826,

URS000075DAF5_9606 miRNA 17 2

RefSeq: NR_036181,

miRBase: MIMAT0016848,

MIR4293 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4293 Gene

No ASD Table

Relevant External Links for MIR4293 Gene

GeneLoc Exon Structure for
MIR4293

No data available for mRNA/cDNA for MIR4293 Gene

Expression for MIR4293 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR4293

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4293 Gene

Orthologs for MIR4293 Gene

Evolution for MIR4293 Gene

ENSEMBL:
Gene Tree for MIR4293 (if available)
TreeFam:
Gene Tree for MIR4293 (if available)

No data available for Orthologs for MIR4293 Gene

Paralogs for MIR4293 Gene

No data available for Paralogs for MIR4293 Gene

Variants for MIR4293 Gene

Additional dbSNP identifiers (rs#s) for MIR4293 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4293 Gene

Variant ID Type Subtype PubMed ID
esv34151 CNV loss 18971310
nsv5866 CNV insertion 18451855

Additional Variant Information for MIR4293 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4293

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4293 Gene

Disorders for MIR4293 Gene

No disorders were found for MIR4293 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4293 Gene

Publications for MIR4293 Gene

  1. Genetic variant of miR-4293 rs12220909 is associated with susceptibility to non-small cell lung cancer in a Chinese Han population. (PMID: 28410417) Fan L … Wang M (PloS one 2017) 3
  2. miR-449b rs10061133 and miR-4293 rs12220909 polymorphisms are associated with decreased esophageal squamous cell carcinoma in a Chinese population. (PMID: 26055141) Zhang P … Wang M (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015) 3
  3. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff LA … Hart RP (PloS one 2009) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4293 Gene

Sources for MIR4293 Gene