MIR4293 Gene (RNA Gene)

MicroRNA 4293

GC10M014425
GIFtS:
12
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4293 Gene

Subcategory (RNA class) for MIR4293 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR4293 Gene

  • MicroRNA 4293 2 3 5
  • Hsa-Mir-4293 3
  • MIMAT0016848 53
  • MI0015826 53
  • MIR4293 2

External Ids for MIR4293 Gene

Previous GeneCards Identifiers for MIR4293 Gene

  • GC10U901347

Summaries for MIR4293 Gene

Entrez Gene Summary for MIR4293 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4293 Gene

MIR4293 (MicroRNA 4293) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4293 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4293 Gene

Genomics for MIR4293 Gene

GeneHancer (GH) Regulatory Elements for MIR4293 Gene

Promoters and enhancers for MIR4293 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH10J014381 Enhancer 1.1 Ensembl ENCODE dbSUPER 750.6 -0.9 -882 6.2 ZNF24 CTCF RELA BCL6B MAFK ZNF687 IKZF1 ZIC2 IKZF2 ZSCAN4 MIR4293 MIR1265 ENSG00000278100 FRMD4A
GH10J014378 Enhancer 0.6 Ensembl dbSUPER 0.6 +4.5 4476 0.4 HLF ZBTB11 NR2C2 GABPA MIR4293 ENSG00000285671 FRMD4A
GH10J014379 Enhancer 0.5 Ensembl dbSUPER 0.6 +3.6 3577 1 ZBTB11 NR2C2 MIR4293 ENSG00000285671 FRMD4A
GH10J014375 Enhancer 0.5 FANTOM5 0.4 +8.0 7997 0.3 PRDM1 CEBPB ATF7 GABPA CEBPG ENSG00000285671 MIR4293 FRMD4A
GH10J014380 Enhancer 0.2 ENCODE 0.6 +2.4 2380 0.2 MIR4293 ENSG00000285671 FRMD4A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4293 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4293 Gene

Genomic Locations for MIR4293 Gene
chr10:14,383,200-14,383,277
(GRCh38/hg38)
Size:
78 bases
Orientation:
Minus strand
chr10:14,425,199-14,425,276
(GRCh37/hg19)
Size:
78 bases
Orientation:
Minus strand

Genomic View for MIR4293 Gene

Genes around MIR4293 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4293 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4293 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR4293 Gene

Proteins for MIR4293 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR4293 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4293 Gene

Domains & Families for MIR4293 Gene

Gene Families for MIR4293 Gene

HGNC:
genes like me logo Genes that share domains with MIR4293: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4293 Gene

Function for MIR4293 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4293 Gene

Localization for MIR4293 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4293 Gene

Pathways & Interactions for MIR4293 Gene

PathCards logo

SuperPathways for MIR4293 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4293 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4293 Gene

Drugs & Compounds for MIR4293 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR4293 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR4293 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNACentral transcripts :
(2) miRBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4293 Gene

No ASD Table

Relevant External Links for MIR4293 Gene

GeneLoc Exon Structure for
MIR4293
ECgene alternative splicing isoforms for
MIR4293

Expression for MIR4293 Gene

Products:

  1. Primer
  2. Gene Expression Assay

NURSA nuclear receptor signaling pathways regulating expression of MIR4293 Gene:

MIR4293
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4293 Gene

Orthologs for MIR4293 Gene

Evolution for MIR4293 Gene

ENSEMBL:
Gene Tree for MIR4293 (if available)
TreeFam:
Gene Tree for MIR4293 (if available)

No data available for Orthologs for MIR4293 Gene

Paralogs for MIR4293 Gene

No data available for Paralogs for MIR4293 Gene

Variants for MIR4293 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MIR4293 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000401696 -- 14,382,833(-) G/C downstream_transcript_variant
rs1000868314 -- 14,382,716(-) AAAAAAAA/AAAAAAA/AAAAAAAAA downstream_transcript_variant
rs1001549968 -- 14,382,969(-) G/C downstream_transcript_variant
rs1002863017 -- 14,384,967(-) T/A/C upstream_transcript_variant
rs1004252379 -- 14,383,197(-) T/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4293 Gene

Variant ID Type Subtype PubMed ID
esv34151 CNV loss 18971310
nsv5866 CNV insertion 18451855

Additional Variant Information for MIR4293 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4293

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4293 Gene

Disorders for MIR4293 Gene

Additional Disease Information for MIR4293

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR4293 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4293 Gene

Publications for MIR4293 Gene

  1. Genetic variant of miR-4293 rs12220909 is associated with susceptibility to non-small cell lung cancer in a Chinese Han population. (PMID: 28410417) Fan L … Wang M (PloS one 2017) 3 56
  2. miR-449b rs10061133 and miR-4293 rs12220909 polymorphisms are associated with decreased esophageal squamous cell carcinoma in a Chinese population. (PMID: 26055141) Zhang P … Wang M (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015) 3 56
  3. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff LA … Hart RP (PloS one 2009) 3 56
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 56

ExternalLinks

View latest publications for MIR4293 gene in Mastermind

Products for MIR4293 Gene

Sources for MIR4293 Gene