Free for academic non-profit institutions. Other users need a Commercial license
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR4293 (MicroRNA 4293) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH10J014381 | Enhancer | 1.1 | Ensembl ENCODE dbSUPER | 600.7 | -0.9 | -882 | 6.2 | RELA ZIC2 ZSCAN4 TCF12 IKZF2 SP1 DPF2 RELB JUND CEBPB | MIR4293 MIR1265 ENSG00000278100 FRMD4A ENSG00000282246 | |
GH10J014378 | Enhancer | 0.6 | Ensembl dbSUPER | 0.7 | +4.5 | 4476 | 0.4 | NR2C2 ZBTB11 GABPA HLF USF2 NR2C1 | MIR4293 ENSG00000285671 FRMD4A ENSG00000282246 | |
GH10J014379 | Enhancer | 0.5 | Ensembl dbSUPER | 0.7 | +3.6 | 3577 | 1 | NR2C2 ZBTB11 | MIR4293 ENSG00000285671 FRMD4A ENSG00000282246 | |
GH10J014375 | Enhancer | 0.6 | FANTOM5 | 0.4 | +8.0 | 7997 | 0.3 | ATF7 PRDM1 CEBPB GABPA PCBP1 CEBPG ATF4 ATF3 | ENSG00000285671 MIR4293 FRMD4A ENSG00000282246 | |
GH10J014380 | Enhancer | 0.2 | ENCODE | 0.7 | +2.4 | 2380 | 0.2 | MIR4293 ENSG00000285671 FRMD4A ENSG00000282246 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075C2F1_9606 | precursor_RNA | 78 | 4 |
HGNC: 38270, RefSeq: NR_036181, Ensembl: ENST00000584305 (view in UCSC) , miRBase: MI0015826, |
URS000075DAF5_9606 | miRNA | 17 | 2 |
RefSeq: NR_036181, miRBase: MIMAT0016848, |
No disorders were found for MIR4293 Gene.