microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR429 Gene

Subcategory (RNA class) for MIR429 Gene

miRNA

Quality Score for this RNA gene is

16

Aliases for MIR429 Gene

  • MicroRNA 429 2 3 5
  • Hsa-MiR-429 168 179
  • MIMAT0001536 53
  • Hsa-Mir-429 3
  • MI0001641 53
  • Mir-429 3
  • MIRN429 3
  • MIR429 2

External Ids for MIR429 Gene

Previous HGNC Symbols for MIR429 Gene

  • MIRN429

Previous GeneCards Identifiers for MIR429 Gene

  • GC01P001102
  • GC01P001105
  • GC01P001109
  • GC01P001116
  • GC01P001130
  • GC01P001171
  • GC01P001175
  • GC01P001209
  • GC01P001212
  • GC01P001177
  • GC01P001180
  • GC01P001183
  • GC01P001186
  • GC01P001192
  • GC01P001196
  • GC01P001199
  • GC01P001203

Summaries for MIR429 Gene

Entrez Gene Summary for MIR429 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR429 Gene

MIR429 (MicroRNA 429) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR429 include Ovarian Cancer and Lung Cancer. Among its related pathways are miRNA targets in ECM and membrane receptors.

Additional gene information for MIR429 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR429 Gene

Genomics for MIR429 Gene

GeneHancer (GH) Regulatory Elements for MIR429 Gene

Promoters and enhancers for MIR429 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J001168 Enhancer 0.5 dbSUPER 750.6 -0.6 -627 0.6 HNF1A GLIS2 SOX13 GATAD2A SAP130 POLR2A ARID4B RARA ENSG00000272141 MIR200A MIR200B MIR429 RF00241
GH01J001109 Enhancer 0.8 ENCODE 11.7 -59.1 -59146 1.1 ZBTB40 SMARCE1 L3MBTL2 TEAD4 GTF2F1 SMARCA4 TRIM24 MTA1 IKZF1 DPF2 lnc-RNF223-4 piR-58273 LINC01786 UBE2J2 MIR200A MIR200B MIR429 PERM1 PLEKHN1 C1orf159
GH01J001189 Enhancer 0.5 FANTOM5 Ensembl 13.6 +20.4 20396 2 LARP7 SDF4 B3GALT6 MIR200A MIR200B MIR429 UBE2J2 LINC01786 C1QTNF12 TNFRSF18 ENSG00000237094
GH01J001108 Enhancer 0.5 Ensembl 11.6 -60.4 -60404 0.8 ZNF785 ZBTB5 ZNF146 YY2 ZNF558 piR-40348-001 lnc-RNF223-4 LINC01786 UBE2J2 MIR200A MIR200B MIR429 PERM1 PLEKHN1 C1orf159
GH01J001110 Enhancer 0.3 Ensembl 11.7 -58.1 -58104 0.2 MLLT1 ZBTB33 lnc-RNF223-4 piR-58273 LINC01786 UBE2J2 MIR200A MIR200B MIR429 PERM1 PLEKHN1 C1orf159
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR429 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR429 Gene

Genomic Locations for MIR429 Gene
chr1:1,169,005-1,169,087
(GRCh38/hg38)
Size:
83 bases
Orientation:
Plus strand
chr1:1,104,385-1,104,467
(GRCh37/hg19)
Size:
83 bases
Orientation:
Plus strand

Genomic View for MIR429 Gene

Genes around MIR429 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR429 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR429 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR429 Gene

Proteins for MIR429 Gene

Post-translational modifications for MIR429 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR429 Gene

Domains & Families for MIR429 Gene

Gene Families for MIR429 Gene

genes like me logo Genes that share domains with MIR429: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR429 Gene

Function for MIR429 Gene

Gene Ontology (GO) - Molecular Function for MIR429 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 25152461
genes like me logo Genes that share ontologies with MIR429: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR429 Gene

Localization for MIR429 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR429 gene
Compartment Confidence
extracellular 1
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR429 Gene

Pathways & Interactions for MIR429 Gene

PathCards logo

SuperPathways for MIR429 Gene

genes like me logo Genes that share pathways with MIR429: view

Pathways by source for MIR429 Gene

1 BioSystems pathway for MIR429 Gene

Gene Ontology (GO) - Biological Process for MIR429 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 25152461
genes like me logo Genes that share ontologies with MIR429: view

No data available for SIGNOR curated interactions for MIR429 Gene

Drugs & Compounds for MIR429 Gene

No Compound Related Data Available

Transcripts for MIR429 Gene

mRNA/cDNA for MIR429 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNACentral transcripts :
(2) miRBase transcripts :
(3) ENA transcripts :
(1) TarBase transcripts :
(1) LncBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR429 Gene

No ASD Table

Relevant External Links for MIR429 Gene

GeneLoc Exon Structure for
MIR429
ECgene alternative splicing isoforms for
MIR429

Expression for MIR429 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR429 Gene

mRNA differential expression in normal tissues according to GTEx for MIR429 Gene

This gene is overexpressed in Colon - Transverse (x9.9), Pituitary (x6.6), Stomach (x5.1), Pancreas (x4.3), and Small Intestine - Terminal Ileum (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of MIR429 Gene:

MIR429
genes like me logo Genes that share expression patterns with MIR429: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR429 Gene

Orthologs for MIR429 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR429 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-429 33
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir429 33
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-429 33
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-429 33
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-429 33
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-429 33
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-429 33
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-429a 33
  • 72 (a)
OneToMany
dre-mir-429b 33
  • 50 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-141 33
  • 55 (a)
OneToMany
Species where no ortholog for MIR429 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR429 Gene

ENSEMBL:
Gene Tree for MIR429 (if available)
TreeFam:
Gene Tree for MIR429 (if available)

Paralogs for MIR429 Gene

No data available for Paralogs for MIR429 Gene

Variants for MIR429 Gene

Sequence variations from dbSNP and Humsavar for MIR429 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1001809323 -- 1,167,265(+) C/T upstream_transcript_variant
rs1002688307 -- 1,168,905(+) G/T upstream_transcript_variant
rs1003284241 -- 1,167,958(+) G/A/C upstream_transcript_variant
rs1003746029 -- 1,168,109(+) G/A upstream_transcript_variant
rs1003848660 -- 1,168,130(+) C/A/G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR429 Gene

Variant ID Type Subtype PubMed ID
dgv2n67 CNV gain 20364138
nsv1003578 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1160644 CNV deletion 26073780
nsv1160772 CNV duplication 26073780
nsv428334 CNV gain 18775914
nsv469848 CNV gain 16826518
nsv470680 CNV loss 18288195
nsv482937 CNV loss 15286789
nsv509257 CNV insertion 20534489
nsv517709 CNV gain+loss 19592680
nsv544947 CNV loss 21841781
nsv544954 CNV loss 21841781
nsv950452 CNV deletion 24416366

Additional Variant Information for MIR429 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR429

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR429 Gene

Disorders for MIR429 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MIR429 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • ovarian cancer, somatic
lung cancer
  • adenocarcinoma of lung
breast cancer
  • breast cancer, familial
non-alcoholic fatty liver disease
  • nafld
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR429

genes like me logo Genes that share disorders with MIR429: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR429 Gene

Publications for MIR429 Gene

  1. miR-429 suppresses cell growth and induces apoptosis of human thyroid cancer cell by targeting ZEB1. (PMID: 30849921) Wu G … Wang X (Artificial cells, nanomedicine, and biotechnology 2019) 3 56
  2. MicroRNA 429 regulates the expression of CHMP5 in the inflammatory colitis and colorectal cancer cells. (PMID: 30334065) Mo JS … Chae SC (Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2018) 3 56
  3. miR-429 suppresses tumor migration and invasion by targeting CRKL in hepatocellular carcinoma via inhibiting Raf/MEK/ERK pathway and epithelial-mesenchymal transition. (PMID: 29403024) Guo C … Sun MZ (Scientific reports 2018) 3 56
  4. MiR-429 improved the hypoxia tolerance of human amniotic cells by targeting HIF-1α. (PMID: 30145667) Ge L … Yu D (Biotechnology letters 2018) 3 56
  5. Long Noncoding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Promotes Renal Cell Carcinoma Progression via Sponging miRNA-429. (PMID: 29588438) Jiang LT … Cai J (Medical science monitor : international medical journal of experimental and clinical research 2018) 3 56

Products for MIR429 Gene

Sources for MIR429 Gene