microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR429 Gene

RNA type for MIR429 Gene

miRNA

Aliases for MIR429 Gene

External Ids for MIR429 Gene

Previous HGNC Symbols for MIR429 Gene

  • MIRN429

Previous GeneCards Identifiers for MIR429 Gene

  • GC01P001102
  • GC01P001105
  • GC01P001109
  • GC01P001116
  • GC01P001130
  • GC01P001171
  • GC01P001175
  • GC01P001209
  • GC01P001212
  • GC01P001239
  • GC01P001297
  • GC01P001177
  • GC01P001180
  • GC01P001183
  • GC01P001186
  • GC01P001192
  • GC01P001196
  • GC01P001199
  • GC01P001203
  • GC01P001464
  • GC01P001625

Summaries for MIR429 Gene

Entrez Gene Summary for MIR429 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR429 Gene

MIR429 (MicroRNA 429) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR429 include Ovarian Cancer and Lung Cancer. Among its related pathways are miRNA targets in ECM and membrane receptors.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR429 Gene

Genomics for MIR429 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR429 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J001168 Enhancer 0.5 dbSUPER 250.7 -0.6 -627 0.6 SAP130 RARA GABPB1 ARID4B HNF1A SOX13 HNRNPL GATAD2A GLIS2 MIR200A MIR200B MIR429 RF00241 TTLL10 ENSG00000272141 C1orf159
GH01J001109 Enhancer 0.8 ENCODE 11.7 -59.1 -59146 1.1 IKZF1 NCOR1 ZNF592 NFIC NONO REST NFATC3 NBN ZNF146 ATF1 HSALNG0000089 lnc-RNF223-4 piR-58273 LINC01786 UBE2J2 MIR200A MIR200B MIR429 PERM1 PLEKHN1
GH01J001189 Enhancer 0.6 FANTOM5 Ensembl 13.6 +20.3 20296 1.8 SPI1 LARP7 SDF4 B3GALT6 MIR200A MIR200B MIR429 LINC01786 UBE2J2 C1QTNF12 TNFRSF18 ENSG00000237094
GH01J001108 Enhancer 0.5 Ensembl 11.6 -60.4 -60404 0.8 ZBTB5 ZNF146 YY2 ZNF785 ZNF558 HSALNG0000089 lnc-RNF223-4 piR-40348-001 LINC01786 UBE2J2 MIR200A MIR200B MIR429 PERM1 PLEKHN1
GH01J001722 Promoter/Enhancer 0.6 Ensembl dbSUPER 5 +553.3 553296 0.6 ZNF512 piR-36349-002 MIR429 CDK11A ENSG00000268575 SLC35E2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR429 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR429 Gene

Latest Assembly
chr1:1,169,005-1,169,087
(GRCh38/hg38)
Size:
83 bases
Orientation:
Plus strand

Previous Assembly
chr1:1,104,385-1,104,467
(GRCh37/hg19 by Entrez Gene)
Size:
83 bases
Orientation:
Plus strand

chr1:1,104,385-1,104,467
(GRCh37/hg19 by Ensembl)
Size:
83 bases
Orientation:
Plus strand

Genomic View for MIR429 Gene

Genes around MIR429 on UCSC Golden Path with GeneCards custom track
MIR429 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR429 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR429 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR429 Gene

Proteins for MIR429 Gene

Post-translational modifications for MIR429 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR429 Gene

Domains & Families for MIR429 Gene

Gene Families for MIR429 Gene

genes like me logo Genes that share domains with MIR429: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR429 Gene

Function for MIR429 Gene

Gene Ontology (GO) - Molecular Function for MIR429 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 29467620
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 25152461
genes like me logo Genes that share ontologies with MIR429: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR429 Gene

Localization for MIR429 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR429 gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
nucleus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR429 Gene

Pathways & Interactions for MIR429 Gene

PathCards logo

SuperPathways for MIR429 Gene

genes like me logo Genes that share pathways with MIR429: view

Pathways by source for MIR429 Gene

1 BioSystems pathway for MIR429 Gene

Gene Ontology (GO) - Biological Process for MIR429 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 25152461
genes like me logo Genes that share ontologies with MIR429: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR429 Gene

Drugs & Compounds for MIR429 Gene

No Compound Related Data Available

Transcripts for MIR429 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR429 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000055BBE5_9606 miRNA 22 6

RefSeq: NR_029957,

LncBase: hsa-miR-429,

miRBase: MIMAT0001536,

MirGeneDB: Hsa-Mir-8-P3a_3p,

TarBase: hsa-miR-429,

ENA: LM379507.1:1..22:ncRNA, LM609019.1:51..72:ncRNA,

URS000075B715_9606 pre_miRNA 83 4

RefSeq: NR_029957,

Ensembl: ENST00000362106 (view in UCSC) ,

miRBase: MI0001641,

ENA: LM609019.1:1..83:precursor_RNA,

URS0000EFD64F_9606 pre_miRNA 58 1

MirGeneDB: Hsa-Mir-8-P3a,

URS00001BB658_9606 miRNA 21 1

MirGeneDB: Hsa-Mir-8-P3a_5p,

MIR429 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR429 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR429 Gene

No ASD Table

Relevant External Links for MIR429 Gene

GeneLoc Exon Structure for
MIR429

Expression for MIR429 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR429 Gene

mRNA differential expression in normal tissues according to GTEx for MIR429 Gene

This gene is overexpressed in Colon - Transverse (x9.9), Pituitary (x6.6), Stomach (x5.1), Pancreas (x4.3), and Small Intestine - Terminal Ileum (x4.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR429

genes like me logo Genes that share expression patterns with MIR429: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR429 Gene

Orthologs for MIR429 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR429 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia bta-mir-429 30
  • 87 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir429 30
  • 83 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-429 30
  • 79 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-429 30
  • 74 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-429 30
  • 54 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-429 30
  • 69 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-429 30
  • 55 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-429a 30
  • 72 (a)
OneToMany
dre-mir-429b 30
  • 50 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea csa-mir-141 30
  • 55 (a)
OneToMany
Species where no ortholog for MIR429 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR429 Gene

ENSEMBL:
Gene Tree for MIR429 (if available)
TreeFam:
Gene Tree for MIR429 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR429

Paralogs for MIR429 Gene

No data available for Paralogs for MIR429 Gene

Variants for MIR429 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR429 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR429 Gene

Variant ID Type Subtype PubMed ID
dgv2n67 CNV gain 20364138
nsv1003578 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1160644 CNV deletion 26073780
nsv1160772 CNV duplication 26073780
nsv428334 CNV gain 18775914
nsv469848 CNV gain 16826518
nsv470680 CNV loss 18288195
nsv482937 CNV loss 15286789
nsv509257 CNV insertion 20534489
nsv517709 CNV gain+loss 19592680
nsv544947 CNV loss 21841781
nsv544954 CNV loss 21841781
nsv950452 CNV deletion 24416366

Additional Variant Information for MIR429 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR429
Leiden Open Variation Database (LOVD)
MIR429

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR429 Gene

Disorders for MIR429 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MIR429 Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
ovarian cancer
  • ovarian cancer, somatic
lung cancer
  • lung cancer, susceptibility to
breast cancer
  • breast cancer, familial
non-alcoholic fatty liver disease
  • nafld
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR429

genes like me logo Genes that share disorders with MIR429: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR429 Gene

Publications for MIR429 Gene

  1. A miR-200 microRNA cluster as prognostic marker in advanced ovarian cancer. (PMID: 19501389) Hu X … Wang X (Gynecologic oncology 2009) 3 72
  2. A novel ETV6-miR-429-CRKL regulatory circuitry contributes to aggressiveness of hepatocellular carcinoma. (PMID: 32326970) Guo C … Sun MZ (Journal of experimental & clinical cancer research : CR 2020) 3
  3. miR-429-CRKL axis regulates clear cell renal cell carcinoma malignant progression through SOS1/MEK/ERK/MMP2/MMP9 pathway. (PMID: 32413671) Wang J … Sun MZ (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020) 3
  4. MiR-429 regulates blood-spinal cord barrier permeability by targeting Krüppel-like factor 6. (PMID: 32145913) Sun R … Yu D (Biochemical and biophysical research communications 2020) 3
  5. MiR-429-5p attenuates the migration and invasion of malignant melanoma by targeting LIMK1. (PMID: 32196612) Sheng H … Chen ZH (European review for medical and pharmacological sciences 2020) 3

Products for MIR429 Gene

Sources for MIR429 Gene