microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4289 Gene

Subcategory (RNA class) for MIR4289 Gene

miRNA

Number of RNA Genes sources:

1 / 14

Aliases for MIR4289 Gene

  • MicroRNA 4289 2 3 5
  • Hsa-Mir-4289 3
  • MIMAT0016920 51
  • MI0015898 51
  • MIR4289 2

External Ids for MIR4289 Gene

Previous GeneCards Identifiers for MIR4289 Gene

  • GC09U901494
  • GC09M091360

Summaries for MIR4289 Gene

Entrez Gene Summary for MIR4289 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4289 Gene

MIR4289 (MicroRNA 4289) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4289 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4289 Gene

Genomics for MIR4289 Gene

GeneHancer (GH) Regulatory Elements for MIR4289 Gene

Promoters and enhancers for MIR4289 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J088744 Enhancer 1.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas 500.7 -1.4 -1391 5.4 ZSCAN5C JUND PHB2 FOS ZIC2 TRIM28 EP300 CTBP1 JUN MXI1 MIR4289 S1PR3 HSALNG0072566 ENSG00000286414
GH09J088745 Enhancer 0.2 Ensembl 500.7 +1.9 1904 0.4 MIR4289 FJ601684-459 ENSG00000286414
GH09J088742 Enhancer 0.6 Ensembl ENCODE 0.7 +3.1 3117 1.2 FOS CEBPB STAT3 TCF7L2 NR3C1 MYC MIR4289 FJ601684-459 ENSG00000286414
GH09J088773 Enhancer 1.4 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 0.3 -30.3 -30278 4.9 TCF12 JUND FOS CTCF ZIC2 ZNF423 EP300 NR2F2 WT1 ZNF316 CDK20 HSALNG0072566 ENSG00000286414 MIR4289
GH09J088753 Enhancer 0.9 Ensembl ENCODE CraniofacialAtlas 0.4 -8.6 -8638 2.5 NR2F2 RCOR1 RXRA SMARCA4 ZBTB33 HLF CHD2 YY1 GATA2 RAD21 MIR4289 HSALNG0072566 ENSG00000286414
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4289 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4289 Gene

Genomic Locations for MIR4289 Gene
chr9:88,745,836-88,745,905
(GRCh38/hg38)
Size:
70 bases
Orientation:
Minus strand
chr9:91,360,751-91,360,820
(GRCh37/hg19)
Size:
70 bases
Orientation:
Minus strand

Genomic View for MIR4289 Gene

Genes around MIR4289 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4289 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4289 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4289 Gene

Proteins for MIR4289 Gene

Post-translational modifications for MIR4289 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4289 Gene

Domains & Families for MIR4289 Gene

Gene Families for MIR4289 Gene

HGNC:
genes like me logo Genes that share domains with MIR4289: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4289 Gene

Function for MIR4289 Gene

Phenotypes From GWAS Catalog for MIR4289 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4289 Gene

Localization for MIR4289 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4289 Gene

Pathways & Interactions for MIR4289 Gene

PathCards logo

SuperPathways for MIR4289 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR4289 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4289 Gene

Drugs & Compounds for MIR4289 Gene

No Compound Related Data Available

Transcripts for MIR4289 Gene

mRNA/cDNA for MIR4289 Gene

2 RNACentral transcripts :
1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 miRBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4289 Gene

No ASD Table

Relevant External Links for MIR4289 Gene

GeneLoc Exon Structure for
MIR4289

Expression for MIR4289 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4289 Gene

Orthologs for MIR4289 Gene

Evolution for MIR4289 Gene

ENSEMBL:
Gene Tree for MIR4289 (if available)
TreeFam:
Gene Tree for MIR4289 (if available)

No data available for Orthologs for MIR4289 Gene

Paralogs for MIR4289 Gene

No data available for Paralogs for MIR4289 Gene

Variants for MIR4289 Gene

Additional dbSNP identifiers (rs#s) for MIR4289 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4289 Gene

Variant ID Type Subtype PubMed ID
nsv614824 CNV loss 21841781
nsv831650 CNV gain 17160897

Additional Variant Information for MIR4289 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4289

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4289 Gene

Disorders for MIR4289 Gene

Additional Disease Information for MIR4289

No disorders were found for MIR4289 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4289 Gene

Publications for MIR4289 Gene

  1. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff LA … Hart RP (PloS one 2009) 3 54
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 54

Products for MIR4289 Gene

Sources for MIR4289 Gene