microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4287 Gene

Subcategory (RNA class) for MIR4287 Gene

miRNA

Quality Score for this RNA gene is

14

Aliases for MIR4287 Gene

  • MicroRNA 4287 2 3 5
  • Hsa-Mir-4287 3
  • MIMAT0016917 53
  • Hsa-MiR-4287 179
  • MI0015895 53
  • MIR4287 2

External Ids for MIR4287 Gene

Previous GeneCards Identifiers for MIR4287 Gene

  • GC08U901381
  • GC08M027743

Summaries for MIR4287 Gene

Entrez Gene Summary for MIR4287 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4287 Gene

MIR4287 (MicroRNA 4287) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4287 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4287 Gene

Genomics for MIR4287 Gene

GeneHancer (GH) Regulatory Elements for MIR4287 Gene

Promoters and enhancers for MIR4287 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J027884 Enhancer 0.6 Ensembl dbSUPER 750.6 +1.6 1615 0.2 POLR2A ZNF316 ZSCAN5C MIR4287 HSALNG0064210 SCARA5
GH08J027886 Enhancer 0.5 Ensembl ENCODE dbSUPER 750.6 -0.5 -466 0.4 MIR4287 CCDC25 piR-57461-254 SCARA5
GH08J027871 Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 +13.1 13123 4 SIN3A ZBTB40 ZBTB6 POLR2A TCF7L2 ZNF217 CREB1 ZNF362 HLF ZNF121 PBK ENSG00000253176 CCDC25 SCARA3 ELP3 HSALNG0064210 MIR4287 SCARA5
GH08J027879 Enhancer 0.7 Ensembl dbSUPER 0.4 +6.3 6315 0.4 L3MBTL2 GMEB1 ATF1 MGA CTBP1 ZBTB33 SMARCA4 NRF1 MIR4287 HSALNG0064210 SCARA5
GH08J027863 Enhancer 0.8 ENCODE dbSUPER 0.3 +22.1 22127 0.2 CTCF ZNF362 RAD21 ELF3 ZNF384 REST TRIM22 ZNF143 PATZ1 ZBTB48 SCARA5 PBK ENSG00000253176 HSALNG0064210 MIR4287
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4287 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4287 Gene

Genomic Locations for MIR4287 Gene
chr8:27,886,039-27,886,116
(GRCh38/hg38)
Size:
78 bases
Orientation:
Minus strand
chr8:27,743,556-27,743,633
(GRCh37/hg19)
Size:
78 bases
Orientation:
Minus strand

Genomic View for MIR4287 Gene

Genes around MIR4287 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4287 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4287 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4287 Gene

Proteins for MIR4287 Gene

Post-translational modifications for MIR4287 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4287 Gene

Domains & Families for MIR4287 Gene

Gene Families for MIR4287 Gene

HGNC:
genes like me logo Genes that share domains with MIR4287: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4287 Gene

Function for MIR4287 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4287 Gene

Localization for MIR4287 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4287 Gene

Pathways & Interactions for MIR4287 Gene

PathCards logo

SuperPathways for MIR4287 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4287 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4287 Gene

Drugs & Compounds for MIR4287 Gene

No Compound Related Data Available

Transcripts for MIR4287 Gene

mRNA/cDNA for MIR4287 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNACentral transcripts :
(2) miRBase transcripts :
(1) TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4287 Gene

No ASD Table

Relevant External Links for MIR4287 Gene

GeneLoc Exon Structure for
MIR4287
ECgene alternative splicing isoforms for
MIR4287

Expression for MIR4287 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4287 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4287 Gene:

MIR4287
genes like me logo Genes that share expression patterns with MIR4287: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4287 Gene

Orthologs for MIR4287 Gene

Evolution for MIR4287 Gene

ENSEMBL:
Gene Tree for MIR4287 (if available)
TreeFam:
Gene Tree for MIR4287 (if available)

No data available for Orthologs for MIR4287 Gene

Paralogs for MIR4287 Gene

No data available for Paralogs for MIR4287 Gene

Variants for MIR4287 Gene

Sequence variations from dbSNP and Humsavar for MIR4287 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000534188 -- 27,886,497(-) T/A upstream_transcript_variant
rs1001069056 -- 27,888,023(-) T/A/C upstream_transcript_variant
rs1001361928 -- 27,885,910(-) A/G downstream_transcript_variant
rs1002074629 -- 27,886,751(-) C/G upstream_transcript_variant
rs1002105868 -- 27,887,080(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4287 Gene

Variant ID Type Subtype PubMed ID
nsv509259 CNV insertion 20534489
nsv610868 CNV loss 21841781
nsv6133 CNV insertion 18451855

Additional Variant Information for MIR4287 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4287

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4287 Gene

Disorders for MIR4287 Gene

Additional Disease Information for MIR4287

No disorders were found for MIR4287 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4287 Gene

Publications for MIR4287 Gene

  1. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff LA … Hart RP (PloS one 2009) 3 56
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 56

Products for MIR4287 Gene

Sources for MIR4287 Gene