microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4281 Gene

Subcategory (RNA class) for MIR4281 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR4281 Gene

  • MicroRNA 4281 2 3 5
  • Hsa-Mir-4281 3
  • MIMAT0016907 53
  • MI0015885 53
  • MIR4281 2

External Ids for MIR4281 Gene

Previous GeneCards Identifiers for MIR4281 Gene

  • GC05U901444
  • GC05M170980
  • GC05M176056

Summaries for MIR4281 Gene

Entrez Gene Summary for MIR4281 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4281 Gene

MIR4281 (MicroRNA 4281) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4281 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4281 Gene

Genomics for MIR4281 Gene

GeneHancer (GH) Regulatory Elements for MIR4281 Gene

Promoters and enhancers for MIR4281 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J176630 Promoter 1.3 EPDnew Ensembl 750.6 -0.9 -901 0.8 CTCF ZBTB6 MNT SP5 KLF14 GLIS2 PKNOX1 ZIC2 PRDM10 TARDBP EIF4E1B MIR4281 SNCB lnc-EIF4E1B-2 lnc-SNCB-3 GPRIN1 TSPAN17
GH05J176628 Promoter 0.4 Ensembl 750.6 -0.2 -201 0.2 EZH2 EIF4E1B MIR4281 SNCB lnc-EIF4E1B-2 lnc-SNCB-3
GH05J176629 Enhancer 0.3 Ensembl 750.6 +0.7 699 0.4 ZNF623 ZNF664 EIF4E1B MIR4281 SNCB lnc-EIF4E1B-2 lnc-SNCB-3 GPRIN1
GH05J176626 Enhancer 0.5 Ensembl 0.6 +2.8 2843 0.5 ZNF692 EGR1 NFIC ZFHX2 KLF17 KLF1 SNCB TSPAN17 MIR4281 lnc-SNCB-3 GPRIN1
GH05J176620 Enhancer 0.6 ENCODE 0.4 +8.8 8825 0.2 L3MBTL2 ZNF148 GLIS2 PRDM10 SP2 EZH2 EHMT2 ZNF335 NRF1 BHLHE40 HK3 GPRIN1 SNCB MIR4281 lnc-SNCB-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4281 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4281 Gene

Genomic Locations for MIR4281 Gene
chr5:176,629,439-176,629,500
(GRCh38/hg38)
Size:
62 bases
Orientation:
Minus strand
chr5:176,056,440-176,056,501
(GRCh37/hg19)
Size:
62 bases
Orientation:
Minus strand

Genomic View for MIR4281 Gene

Genes around MIR4281 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4281 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4281 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4281 Gene

Proteins for MIR4281 Gene

Post-translational modifications for MIR4281 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4281 Gene

Domains & Families for MIR4281 Gene

Gene Families for MIR4281 Gene

HGNC:
genes like me logo Genes that share domains with MIR4281: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4281 Gene

Function for MIR4281 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4281 Gene

Localization for MIR4281 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4281 Gene

Pathways & Interactions for MIR4281 Gene

PathCards logo

SuperPathways for MIR4281 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4281 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4281 Gene

Drugs & Compounds for MIR4281 Gene

No Compound Related Data Available

Transcripts for MIR4281 Gene

mRNA/cDNA for MIR4281 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNACentral transcripts :
(2) miRBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4281 Gene

No ASD Table

Relevant External Links for MIR4281 Gene

GeneLoc Exon Structure for
MIR4281
ECgene alternative splicing isoforms for
MIR4281

Expression for MIR4281 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4281 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4281 Gene:

MIR4281
genes like me logo Genes that share expression patterns with MIR4281: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4281 Gene

Orthologs for MIR4281 Gene

Evolution for MIR4281 Gene

ENSEMBL:
Gene Tree for MIR4281 (if available)
TreeFam:
Gene Tree for MIR4281 (if available)

No data available for Orthologs for MIR4281 Gene

Paralogs for MIR4281 Gene

No data available for Paralogs for MIR4281 Gene

Variants for MIR4281 Gene

Sequence variations from dbSNP and Humsavar for MIR4281 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000994975 -- 176,630,524(-) G/A upstream_transcript_variant
rs1001048750 -- 176,630,335(-) G/C upstream_transcript_variant
rs1002134149 -- 176,630,238(-) A/G upstream_transcript_variant
rs1003086669 -- 176,629,186(-) T/C downstream_transcript_variant
rs1003798072 -- 176,629,864(-) C/A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4281 Gene

Variant ID Type Subtype PubMed ID
nsv600346 CNV loss 21841781

Additional Variant Information for MIR4281 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4281

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4281 Gene

Disorders for MIR4281 Gene

Additional Disease Information for MIR4281

No disorders were found for MIR4281 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4281 Gene

Publications for MIR4281 Gene

  1. A Cellular MicroRNA Facilitates Regulatory T Lymphocyte Development by Targeting the FOXP3 Promoter TATA-Box Motif. (PMID: 29282311) Zhang Y … Zhang H (Journal of immunology (Baltimore, Md. : 1950) 2018) 3 56
  2. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff LA … Hart RP (PloS one 2009) 3 56
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 56

Products for MIR4281 Gene

Sources for MIR4281 Gene