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Aliases for MIR4281 Gene

Subcategory (RNA class) for MIR4281 Gene


Quality Score for this RNA gene is


Aliases for MIR4281 Gene

  • MicroRNA 4281 2 3 5
  • Hsa-Mir-4281 3

External Ids for MIR4281 Gene

Previous GeneCards Identifiers for MIR4281 Gene

  • GC05U901444
  • GC05M170980
  • GC05M176056

Summaries for MIR4281 Gene

Entrez Gene Summary for MIR4281 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4281 Gene

MIR4281 (MicroRNA 4281) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4281 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4281 Gene

Genomics for MIR4281 Gene

GeneHancer (GH) Regulatory Elements for MIR4281 Gene

Promoters and enhancers for MIR4281 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I176628 Promoter/Enhancer 1.3 EPDnew Ensembl 550.8 -0.2 -160 2.3 PKNOX1 SIN3A ZNF335 GLIS2 SCRT2 ZNF143 SP3 SP5 TSHZ1 ZNF623 EIF4E1B MIR4281 SNCB TSPAN17 GPRIN1 GC05M176632
GH05I176620 Enhancer 0.7 ENCODE 0.4 +8.8 8825 0.2 MAZ L3MBTL2 ETV1 BHLHE40 NRF1 SP2 ZNF148 MITF ZNF335 GLIS2 HK3 GPRIN1 SNCB MIR4281
GH05I176619 Enhancer 0.7 ENCODE 0.4 +10.1 10105 0.2 HDAC1 CTCF RB1 RAD21 CC2D1A CTBP1 GATA2 EGR1 SMC3 ATF7 HK3 GPRIN1 MIR4281
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4281 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4281 Gene

Genomic Locations for MIR4281 Gene
62 bases
Minus strand

Genomic View for MIR4281 Gene

Genes around MIR4281 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4281 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4281 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4281 Gene

ORGUL Member Location for MIR4281 Gene

ORGUL Member Location for MIR4281 gene

Proteins for MIR4281 Gene

Post-translational modifications for MIR4281 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4281 Gene

Domains & Families for MIR4281 Gene

Gene Families for MIR4281 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4281: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4281 Gene

Function for MIR4281 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4281 Gene

Localization for MIR4281 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4281 Gene

Pathways & Interactions for MIR4281 Gene

SuperPathways for MIR4281 Gene

No Data Available

Interacting Proteins for MIR4281 Gene

Gene Ontology (GO) - Biological Process for MIR4281 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR4281 Gene

Drugs & Compounds for MIR4281 Gene

No Compound Related Data Available

Transcripts for MIR4281 Gene

mRNA/cDNA for MIR4281 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4281 Gene

No ASD Table

Relevant External Links for MIR4281 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR4281 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4281 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4281 Gene:

genes like me logo Genes that share expression patterns with MIR4281: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4281 Gene

Orthologs for MIR4281 Gene

Evolution for MIR4281 Gene

Gene Tree for MIR4281 (if available)
Gene Tree for MIR4281 (if available)

No data available for Orthologs for MIR4281 Gene

Paralogs for MIR4281 Gene

No data available for Paralogs for MIR4281 Gene

Variants for MIR4281 Gene

Sequence variations from dbSNP and Humsavar for MIR4281 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000994975 -- 176,630,524(-) G/A upstream_transcript_variant
rs1001048750 -- 176,630,335(-) G/C upstream_transcript_variant
rs1002134149 -- 176,630,238(-) A/G upstream_transcript_variant
rs1003086669 -- 176,629,186(-) T/C downstream_transcript_variant
rs1003798072 -- 176,629,864(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4281 Gene

Variant ID Type Subtype PubMed ID
nsv600346 CNV loss 21841781

Additional Variant Information for MIR4281 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4281 Gene

Disorders for MIR4281 Gene

Additional Disease Information for MIR4281

No disorders were found for MIR4281 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4281 Gene

Publications for MIR4281 Gene

  1. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff LA … Hart RP (PloS one 2009) 3 58
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4281 Gene

Sources for MIR4281 Gene

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