microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4276 Gene

Data sources for MIR4276 Gene:

Subcategory (RNA class) for MIR4276 Gene

miRNA

Aliases for MIR4276 Gene

External Ids for MIR4276 Gene

Previous GeneCards Identifiers for MIR4276 Gene

  • GC04U901256
  • GC04P175344

Summaries for MIR4276 Gene

Entrez Gene Summary for MIR4276 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4276 Gene

MIR4276 (MicroRNA 4276) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4276 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4276 Gene

Genomics for MIR4276 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4276 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J174423 Promoter/Enhancer 1.2 Ensembl ENCODE 250.7 -0.3 -256 1.1 IKZF1 BHLHE40 CEBPB ARNT ZNF395 VEZF1 NBN EP300 TAL1 TAF9B MIR4276 CEP44 FBXO8 ENSG00000261646 LINC02268 HSALNG0038644 lnc-HPGD-2 piR-48049-063 HPGD
GH04J174419 Enhancer 0.9 ENCODE 0.7 -3.4 -3447 1.4 IKZF1 NONO ARNT ZNF395 NBN ZEB2 TAL1 RELA MYNN ZNF316 ENSG00000250596 CEP44 MIR4276 HSALNG0038644 lnc-HPGD-2 piR-48049-063 HPGD
GH04J174400 Enhancer 0.8 Ensembl ENCODE 0.3 -21.2 -21194 4.4 CEBPB EP300 ZEB2 TCF7L2 MLLT1 MAFK NANOG CTBP1 IKZF1 ZNF740 CEP44 piR-48049-063 MIR4276 HSALNG0038644 lnc-HPGD-2 HPGD
GH04J174427 Enhancer 0.3 Ensembl 0.7 +4.1 4106 1.4 MYNN CEBPB HPGD CEP44 MIR4276 piR-56497-123 HSALNG0038644 lnc-HPGD-2
GH04J174398 Enhancer 0.6 Ensembl ENCODE 0.3 -25.0 -25001 1.5 JUND TAL1 FOSL1 ARID1B ATF3 FOS CEP44 piR-48049-063 MIR4276 LOC105377547 HSALNG0038644 lnc-HPGD-2 HPGD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4276 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4276 Gene

Latest Assembly
chr4:174,423,795-174,423,864
(GRCh38/hg38)
Size:
70 bases
Orientation:
Plus strand

Previous Assembly
chr4:175,344,946-175,345,015
(GRCh37/hg19 by Entrez Gene)
Size:
70 bases
Orientation:
Plus strand

chr4:175,344,946-175,345,015
(GRCh37/hg19 by Ensembl)
Size:
70 bases
Orientation:
Plus strand

Genomic View for MIR4276 Gene

Genes around MIR4276 on UCSC Golden Path with GeneCards custom track
MIR4276 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR4276 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4276 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4276 Gene

Proteins for MIR4276 Gene

Post-translational modifications for MIR4276 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4276 Gene

Domains & Families for MIR4276 Gene

Gene Families for MIR4276 Gene

HGNC:
genes like me logo Genes that share domains with MIR4276: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4276 Gene

Function for MIR4276 Gene

Phenotypes From GWAS Catalog for MIR4276 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4276 Gene

Localization for MIR4276 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4276 Gene

Pathways & Interactions for MIR4276 Gene

PathCards logo

SuperPathways for MIR4276 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4276 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4276 Gene

Drugs & Compounds for MIR4276 Gene

No Compound Related Data Available

Transcripts for MIR4276 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4276 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075DD5E_9606 pre_miRNA 70 3

RefSeq: NR_036236,

Ensembl: ENST00000584832 (view in UCSC) ,

miRBase: MI0015882,

URS000075E8E2_9606 miRNA 17 2

RefSeq: NR_036236,

miRBase: MIMAT0016904,

MIR4276 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4276 Gene

No ASD Table

Relevant External Links for MIR4276 Gene

GeneLoc Exon Structure for
MIR4276

No data available for mRNA/cDNA for MIR4276 Gene

Expression for MIR4276 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR4276

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4276 Gene

Orthologs for MIR4276 Gene

Evolution for MIR4276 Gene

ENSEMBL:
Gene Tree for MIR4276 (if available)
TreeFam:
Gene Tree for MIR4276 (if available)

No data available for Orthologs for MIR4276 Gene

Paralogs for MIR4276 Gene

No data available for Paralogs for MIR4276 Gene

Variants for MIR4276 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR4276 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR4276 Gene

Variant ID Type Subtype PubMed ID
nsv596234 CNV gain 21841781

Additional Variant Information for MIR4276 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4276

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4276 Gene

Disorders for MIR4276 Gene

Additional Disease Information for MIR4276

No disorders were found for MIR4276 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4276 Gene

Publications for MIR4276 Gene

  1. Lung epithelial cells resist influenza A infection by inducing the expression of cytochrome c oxidase VIc which is modulated by miRNA 4276. (PMID: 25203353) Othumpangat S … Beezhold DH (Virology 2014) 3
  2. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff LA … Hart RP (PloS one 2009) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4276 Gene

Sources for MIR4276 Gene