microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4268 Gene

Data sources for MIR4268 Gene:

RNA type for MIR4268 Gene

miRNA

Aliases for MIR4268 Gene

External Ids for MIR4268 Gene

Previous GeneCards Identifiers for MIR4268 Gene

  • GC02U902138
  • GC02M220771
  • GC02M219907
  • GC02M219912

Summaries for MIR4268 Gene

Entrez Gene Summary for MIR4268 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4268 Gene

MIR4268 (MicroRNA 4268) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4268 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4268 Gene

Genomics for MIR4268 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4268 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J219906 Enhancer 1 VISTA ENCODE CraniofacialAtlas 250.7 -0.9 -854 2.3 MAFF MAFK ATF2 CREB1 ATF7 MIR4268 PTPRN LOC105373890 lnc-SLC4A3-5 ENSG00000286199 HSALNG0022417-001 LINC02832 SLC4A3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4268 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4268 Gene

Latest Assembly
chr2:219,906,502-219,906,565
(GRCh38/hg38)
Size:
64 bases
Orientation:
Minus strand

Previous Assembly
chr2:220,771,223-220,771,286
(GRCh37/hg19 by Entrez Gene)
Size:
64 bases
Orientation:
Minus strand

chr2:220,771,223-220,771,286
(GRCh37/hg19 by Ensembl)
Size:
64 bases
Orientation:
Minus strand

Genomic View for MIR4268 Gene

Genes around MIR4268 on UCSC Golden Path with GeneCards custom track
MIR4268 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR4268 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4268 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4268 Gene

Proteins for MIR4268 Gene

Post-translational modifications for MIR4268 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4268 Gene

Domains & Families for MIR4268 Gene

Gene Families for MIR4268 Gene

HGNC:
genes like me logo Genes that share domains with MIR4268: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4268 Gene

Function for MIR4268 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4268 Gene

Localization for MIR4268 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4268 Gene

Pathways & Interactions for MIR4268 Gene

PathCards logo

SuperPathways for MIR4268 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4268 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4268 Gene

Drugs & Compounds for MIR4268 Gene

No Compound Related Data Available

Transcripts for MIR4268 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4268 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000075A41B_9606 precursor_RNA 64 3

RefSeq: NR_036228,

Ensembl: ENST00000581624 (view in UCSC) ,

miRBase: MI0015874,

URS000075D63F_9606 miRNA 21 2

RefSeq: NR_036228,

miRBase: MIMAT0016896,

MIR4268 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4268 Gene

No ASD Table

Relevant External Links for MIR4268 Gene

GeneLoc Exon Structure for
MIR4268

No data available for mRNA/cDNA for MIR4268 Gene

Expression for MIR4268 Gene

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4268 Gene

Orthologs for MIR4268 Gene

Evolution for MIR4268 Gene

ENSEMBL:
Gene Tree for MIR4268 (if available)
TreeFam:
Gene Tree for MIR4268 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR4268

No data available for Orthologs for MIR4268 Gene

Paralogs for MIR4268 Gene

No data available for Paralogs for MIR4268 Gene

Variants for MIR4268 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR4268 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for MIR4268 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4268
Leiden Open Variation Database (LOVD)
MIR4268

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR4268 Gene

Disorders for MIR4268 Gene

Additional Disease Information for MIR4268

No disorders were found for MIR4268 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4268 Gene

Publications for MIR4268 Gene

  1. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff LA … Hart RP (PloS one 2009) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4268 Gene

Sources for MIR4268 Gene