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Aliases for MIR4260 Gene

Subcategory (RNA class) for MIR4260 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4260 Gene

  • MicroRNA 4260 2 3 5
  • Hsa-Mir-4260 3

External Ids for MIR4260 Gene

Previous GeneCards Identifiers for MIR4260 Gene

  • GC01U902889
  • GC01M209796

Summaries for MIR4260 Gene

Entrez Gene Summary for MIR4260 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4260 Gene

MIR4260 (MicroRNA 4260) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MET promotes cell motility and Collagen chain trimerization.

Additional gene information for MIR4260 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4260 Gene

Genomics for MIR4260 Gene

GeneHancer (GH) Regulatory Elements for MIR4260 Gene

Promoters and enhancers for MIR4260 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I209627 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.8 -4.2 -4211 1.1 RB1 KLF17 SIN3A BATF ZNF2 RAD21 ZNF335 GLIS2 CBX5 ZNF143 ENSG00000224260 G0S2 LOC101930114 HSD11B1 LAMB3 MIR4260
GH01I209620 Enhancer 0.9 ENCODE dbSUPER 0.8 +2.1 2053 2.4 ZSCAN5A ZNF792 MZF1 ZNF2 E4F1 BCL11B RARA ZNF664 POLR2A SCRT2 ENSG00000224260 LAMB3 MIR4260 CAMK1G
GH01I209625 Enhancer 0.7 Ensembl ENCODE dbSUPER 0.8 -2.4 -2394 1.8 ZNF366 ENSG00000224260 G0S2 LOC101930114 HSD11B1 LAMB3 MIR4260
GH01I209641 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 -19.3 -19321 3.4 BCOR MAX ZMYM3 ZBTB40 RAD21 YY1 FOSL1 ZNF316 POLR2A ADNP G0S2 LAMB3 HSD11B1 LOC101930114 CAMK1G ENSG00000224260 MIR4260
GH01I209607 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 +15.5 15537 1.1 HDGF BACH1 EBF1 BATF RELA FOSL1 ATF7 FOS FOSL2 IKZF2 ENSG00000224260 CAMK1G HSD11B1 G0S2 LOC101930114 MIR4260
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4260 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4260 Gene

Genomic Locations for MIR4260 Gene
chr1:209,623,444-209,623,510
(GRCh38/hg38)
Size:
67 bases
Orientation:
Minus strand
chr1:209,796,789-209,796,855
(GRCh37/hg19)

Genomic View for MIR4260 Gene

Genes around MIR4260 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4260 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4260 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4260 Gene

ORGUL Member Location for MIR4260 Gene

ORGUL Member Location for MIR4260 gene

Proteins for MIR4260 Gene

Post-translational modifications for MIR4260 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4260 Gene

Domains & Families for MIR4260 Gene

Gene Families for MIR4260 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4260: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4260 Gene

Function for MIR4260 Gene

Phenotypes From GWAS Catalog for MIR4260 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4260 Gene

Localization for MIR4260 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4260 Gene

Drugs & Compounds for MIR4260 Gene

No Compound Related Data Available

Transcripts for MIR4260 Gene

mRNA/cDNA for MIR4260 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4260 Gene

No ASD Table

Relevant External Links for MIR4260 Gene

GeneLoc Exon Structure for
MIR4260
ECgene alternative splicing isoforms for
MIR4260

Expression for MIR4260 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4260 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4260 Gene:

MIR4260
genes like me logo Genes that share expression patterns with MIR4260: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4260 Gene

Orthologs for MIR4260 Gene

Evolution for MIR4260 Gene

ENSEMBL:
Gene Tree for MIR4260 (if available)
TreeFam:
Gene Tree for MIR4260 (if available)

No data available for Orthologs for MIR4260 Gene

Paralogs for MIR4260 Gene

No data available for Paralogs for MIR4260 Gene

Variants for MIR4260 Gene

Sequence variations from dbSNP and Humsavar for MIR4260 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1057516486 likely-pathogenic, pathogenic, Junctional epidermolysis bullosa gravis of Herlitz, not provided 209,623,517(-) GGG/GG upstream_transcript_variant
rs1057516822 likely-pathogenic, Junctional epidermolysis bullosa gravis of Herlitz 209,623,966(-) GGGG/GGG upstream_transcript_variant
rs1057516838 likely-pathogenic, Junctional epidermolysis bullosa gravis of Herlitz 209,623,503(-) A/G non_coding_transcript_variant
rs1057517207 likely-pathogenic, Junctional epidermolysis bullosa gravis of Herlitz 209,623,693(-) G/A upstream_transcript_variant
rs113339950 likely-benign, Epidermolysis bullosa, junctional 209,622,969(-) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4260 Gene

Variant ID Type Subtype PubMed ID
dgv143e212 CNV loss 25503493

Additional Variant Information for MIR4260 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4260

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4260 Gene

Disorders for MIR4260 Gene

Additional Disease Information for MIR4260

No disorders were found for MIR4260 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4260 Gene

Publications for MIR4260 Gene

  1. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff LA … Hart RP (PloS one 2009) 3 58
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58
  3. Therapeutic Inhibition of miR-4260 Suppresses Colorectal Cancer via Targeting MCC and SMAD4. (PMID: 28638476) Xiao J … Huang Q (Theranostics 2017) 3

Products for MIR4260 Gene

Sources for MIR4260 Gene

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