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Aliases for MIR4259 Gene

Subcategory (RNA class) for MIR4259 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR4259 Gene

  • MicroRNA 4259 2 3 5
  • Hsa-Mir-4259 3

External Ids for MIR4259 Gene

Previous GeneCards Identifiers for MIR4259 Gene

  • GC01U902901
  • GC01M159872

Summaries for MIR4259 Gene

Entrez Gene Summary for MIR4259 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4259 Gene

MIR4259 (MicroRNA 4259) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4259 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4259 Gene

Genomics for MIR4259 Gene

GeneHancer (GH) Regulatory Elements for MIR4259 Gene

Promoters and enhancers for MIR4259 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I159899 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.8 -811 2.5 CTCF HDAC1 MEIS2 SIN3A BMI1 E2F1 CTBP1 GATA3 POLR2A VEZF1 MIR4259 CFAP45 ENSG00000272668 SNHG28 GC01P159904 PIR60584 GC01M159886
GH01I159898 Enhancer 0.8 Ensembl ENCODE dbSUPER 550.8 +1.4 1374 1.2 SCRT2 ZNF24 MIR4259 CFAP45 ENSG00000272668 SNHG28 VSIG8 GC01M159886 ENSG00000256029
GH01I159888 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +9.6 9596 3 HDGF ATF1 SIN3A ZNF2 IRF4 GLIS2 ARID2 ZNF207 ZNF143 ATF7 ENSG00000272668 SLAMF8 SNHG28 FCRL6 VSIG8 ENSG00000212161 IGSF9 DUSP23 PIGM SLAMF9
GH01I159896 Enhancer 0.8 Ensembl dbSUPER 0.8 +3.6 3617 0.7 CTCF ZNF316 NCOR1 CBFA2T3 CBFA2T2 DPF2 EMSY NR2F2 CFAP45 MIR4259 GC01M159886 ENSG00000256029
GH01I159881 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +17.9 17944 1.7 PKNOX1 SMAD1 ATF7 FOS DEK ZNF491 ZNF518A ZNF592 MAFF SMARCA4 RPSAP18 ENSG00000272668 SNHG28 LOC100287049 SLAMF8 PIGM DCAF8 CADM3 CADM3-AS1 COPA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4259 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4259 Gene

Genomic Locations for MIR4259 Gene
chr1:159,899,979-159,900,079
(GRCh38/hg38)
Size:
101 bases
Orientation:
Minus strand
chr1:159,869,769-159,869,869
(GRCh37/hg19)

Genomic View for MIR4259 Gene

Genes around MIR4259 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4259 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4259 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4259 Gene

ORGUL Member Location for MIR4259 Gene

ORGUL Member Location for MIR4259 gene

Proteins for MIR4259 Gene

Post-translational modifications for MIR4259 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4259 Gene

Domains & Families for MIR4259 Gene

Gene Families for MIR4259 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4259: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4259 Gene

Function for MIR4259 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4259 Gene

Localization for MIR4259 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4259 Gene

Pathways & Interactions for MIR4259 Gene

SuperPathways for MIR4259 Gene

No Data Available

Interacting Proteins for MIR4259 Gene

Gene Ontology (GO) - Biological Process for MIR4259 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4259 Gene

Drugs & Compounds for MIR4259 Gene

No Compound Related Data Available

Transcripts for MIR4259 Gene

mRNA/cDNA for MIR4259 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4259 Gene

No ASD Table

Relevant External Links for MIR4259 Gene

GeneLoc Exon Structure for
MIR4259
ECgene alternative splicing isoforms for
MIR4259

Expression for MIR4259 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4259 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4259 Gene:

MIR4259
genes like me logo Genes that share expression patterns with MIR4259: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4259 Gene

Orthologs for MIR4259 Gene

Evolution for MIR4259 Gene

ENSEMBL:
Gene Tree for MIR4259 (if available)
TreeFam:
Gene Tree for MIR4259 (if available)

No data available for Orthologs for MIR4259 Gene

Paralogs for MIR4259 Gene

No data available for Paralogs for MIR4259 Gene

Variants for MIR4259 Gene

Sequence variations from dbSNP and Humsavar for MIR4259 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000743300 -- 159,901,477(-) T/C upstream_transcript_variant
rs1002971262 -- 159,901,776(-) G/T upstream_transcript_variant
rs1003225060 -- 159,900,065(-) C/T non_coding_transcript_variant
rs1003842048 -- 159,900,727(-) T/C upstream_transcript_variant
rs1003970894 -- 159,900,453(-) C/A upstream_transcript_variant

Additional Variant Information for MIR4259 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4259

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR4259 Gene

Disorders for MIR4259 Gene

Additional Disease Information for MIR4259

No disorders were found for MIR4259 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4259 Gene

Publications for MIR4259 Gene

  1. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff LA … Hart RP (PloS one 2009) 3 58
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4259 Gene

Sources for MIR4259 Gene

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