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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR4256 (MicroRNA 4256) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01J112461 | Enhancer | 0.5 | ENCODE | 600.7 | +0.1 | 139 | 0.2 | ZNF24 KDM4B TAL1 KDM1A TEAD4 CBFA2T3 ATF1 | MIR4256 WNT2B lnc-WNT2B-1 CTTNBP2NL | |
GH01J112463 | Enhancer | 0.3 | ENCODE | 600.7 | +0.5 | 519 | 0.2 | SMARCE1 | MIR4256 lnc-WNT2B-1 WNT2B CTTNBP2NL | |
GH01J112462 | Promoter/Enhancer | 1.7 | Ensembl ENCODE CraniofacialAtlas | 0.7 | -2.9 | -2934 | 5 | GATAD2A CTCF PRDM10 ZNF629 LEF1 IKZF1 KDM1A ZNF692 BACH1 TARDBP | WNT2B ENSG00000232499 DDX20 ST7L LRIG2 CTTNBP2NL MIR4256 | |
GH01J112456 | Enhancer | 0.6 | Ensembl ENCODE | 0.7 | +4.5 | 4464 | 2.5 | CEBPB FOS MAFK | CTTNBP2NL WNT2B ENSG00000238761 MIR4256 lnc-WNT2B-1 | |
GH01J112451 | Enhancer | 0.2 | Ensembl | 0.4 | +10.2 | 10232 | 0.8 | lnc-WNT2B-1 CTTNBP2NL WNT2B MIR4256 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075B95C_9606 | precursor_RNA | 64 | 4 |
HGNC: 38388, RefSeq: NR_036210, Ensembl: ENST00000636356 (view in UCSC) , miRBase: MI0015855, |
URS000075D5EF_9606 | miRNA | 18 | 2 |
RefSeq: NR_036210, miRBase: MIMAT0016877, |
No disorders were found for MIR4256 Gene.