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Aliases for MIR4253 Gene

Subcategory (RNA class) for MIR4253 Gene


Quality Score for this RNA gene is


Aliases for MIR4253 Gene

  • MicroRNA 4253 2 3 5
  • Hsa-Mir-4253 3

External Ids for MIR4253 Gene

Previous GeneCards Identifiers for MIR4253 Gene

  • GC01U902923
  • GC01M023189

Summaries for MIR4253 Gene

Entrez Gene Summary for MIR4253 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4253 Gene

MIR4253 (MicroRNA 4253) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR4253 include Prostate Cancer/Brain Cancer Susceptibility.

Additional gene information for MIR4253 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4253 Gene

Genomics for MIR4253 Gene

GeneHancer (GH) Regulatory Elements for MIR4253 Gene

Promoters and enhancers for MIR4253 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J022860 Enhancer 0.9 Ensembl ENCODE 600.7 +1.5 1535 2.2 CTCF ZNF600 ZNF143 REST TRIM22 CEBPB ZBTB17 RAD21 SMC3 CUX1 MIR4253 ENSG00000225952 EPHB2
GH01J022876 Enhancer 0.7 Ensembl ENCODE 0.4 -13.1 -13075 2.6 ZNF239 PTBP1 ZFHX2 BCOR ZNF16 EGR2 SMARCA5 KDM1A LINC01355 ENSG00000225952 ELOA MIR4253 GC01P022918 EPHB2
GH01J022859 Enhancer 0.4 Ensembl 0.7 +3.2 3225 0.8 ZFHX2 ZNF146 EGR2 MIR4253 ENSG00000225952 EPHB2
GH01J022889 Enhancer 0.8 Ensembl ENCODE 0.3 -25.2 -25175 2.4 CTCF RAD21 ARID2 ZNF600 REST TRIM22 FOS SMC3 ZNF654 JUN ENSG00000225952 LACTBL1 GC01P022918 MIR4253 EPHB2
GH01J022867 Enhancer 0.4 Ensembl 0.7 -4.1 -4075 0.2 BCOR KDM1A MIR4253 GC01P022918 EPHB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4253 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4253 Gene

Genomic Locations for MIR4253 Gene
68 bases
Minus strand
68 bases
Minus strand

Genomic View for MIR4253 Gene

Genes around MIR4253 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4253 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4253 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4253 Gene

Proteins for MIR4253 Gene

Post-translational modifications for MIR4253 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4253 Gene

Domains & Families for MIR4253 Gene

Gene Families for MIR4253 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4253: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4253 Gene

Function for MIR4253 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4253 Gene

Localization for MIR4253 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4253 Gene

Pathways & Interactions for MIR4253 Gene

PathCards logo

SuperPathways for MIR4253 Gene

No Data Available

Interacting Proteins for MIR4253 Gene

Gene Ontology (GO) - Biological Process for MIR4253 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR4253 Gene

Drugs & Compounds for MIR4253 Gene

No Compound Related Data Available

Transcripts for MIR4253 Gene

mRNA/cDNA for MIR4253 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNA Central transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4253 Gene

No ASD Table

Relevant External Links for MIR4253 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR4253 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4253 Gene:

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4253 Gene

Orthologs for MIR4253 Gene

Evolution for MIR4253 Gene

Gene Tree for MIR4253 (if available)
Gene Tree for MIR4253 (if available)

No data available for Orthologs for MIR4253 Gene

Paralogs for MIR4253 Gene

No data available for Paralogs for MIR4253 Gene

Variants for MIR4253 Gene

Sequence variations from dbSNP and Humsavar for MIR4253 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs35882952 pathogenic, Prostate cancer/brain cancer susceptibility 22,863,060(-) G/C/T downstream_transcript_variant
rs1553171703 uncertain-significance, not specified 22,863,034(-) C/G downstream_transcript_variant
rs1003022795 -- 22,863,564(-) G/A/T upstream_transcript_variant
rs1003339055 -- 22,863,282(-) G/A upstream_transcript_variant
rs1004210362 -- 22,864,114(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4253 Gene

Variant ID Type Subtype PubMed ID
nsv469829 CNV loss 16826518
nsv528926 CNV loss 19592680

Additional Variant Information for MIR4253 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4253 Gene

Disorders for MIR4253 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR4253 Gene - From: GeneCards

Disorder Aliases PubMed IDs
prostate cancer/brain cancer susceptibility
  • pcbc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR4253

genes like me logo Genes that share disorders with MIR4253: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR4253 Gene

Publications for MIR4253 Gene

  1. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff LA … Hart RP (PloS one 2009) 3 58
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4253 Gene

Sources for MIR4253 Gene

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