microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR424 Gene

Subcategory (RNA class) for MIR424 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR424 Gene

  • MicroRNA 424 2 3 5
  • Hsa-MiR-424-3p 166 177
  • Hsa-MiR-424-5p 166 177
  • MIMAT0001341 51
  • MIMAT0004749 51
  • Hsa-Mir-424 3
  • MI0001446 51
  • MiRNA424 3
  • Mir-424 3
  • MIRN424 3
  • RF00737 172
  • MIR322 3
  • MIR424 2

External Ids for MIR424 Gene

Previous HGNC Symbols for MIR424 Gene

  • MIRN424

Previous GeneCards Identifiers for MIR424 Gene

  • GC0XM133521
  • GC0XM133523
  • GC0XM133681
  • GC0XM133686
  • GC0XM133696
  • GC0XM133713
  • GC0XM134549
  • GC0XM134556
  • GC0XM134609
  • GC0XM134614
  • GC0XM134618
  • GC0XM134566
  • GC0XM134571
  • GC0XM134576
  • GC0XM134581
  • GC0XM134586
  • GC0XM134591
  • GC0XM134597
  • GC0XM134604

Summaries for MIR424 Gene

Entrez Gene Summary for MIR424 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR424 Gene

MIR424 (MicroRNA 424) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR424 include Leukemia, Chronic Lymphocytic and Intrahepatic Cholangiocarcinoma.

Rfam classification for MIR424 Gene

Additional gene information for MIR424 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR424 Gene

Genomics for MIR424 Gene

GeneHancer (GH) Regulatory Elements for MIR424 Gene

Promoters and enhancers for MIR424 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ134541 Promoter/Enhancer 2 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 -1.5 -1476 12.4 HNRNPK ZSCAN5C TCF12 PHF8 ZIC2 REST POLR2A ZBTB11 ZNF423 AFF1 MIR503HG MIR424 MIR503 LINC00629 ZNF75D lnc-HPRT1-6 RF00017-8731
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR424 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR424 Gene

Genomic Locations for MIR424 Gene
chrX:134,546,614-134,546,711
(GRCh38/hg38)
Size:
98 bases
Orientation:
Minus strand
chrX:133,677,367-133,680,741
(GRCh37/hg19)
Size:
3,375 bases
Orientation:
Minus strand

Genomic View for MIR424 Gene

Genes around MIR424 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR424 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR424 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR424 Gene

Proteins for MIR424 Gene

Post-translational modifications for MIR424 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR424 Gene

Domains & Families for MIR424 Gene

Gene Families for MIR424 Gene

genes like me logo Genes that share domains with MIR424: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR424 Gene

Function for MIR424 Gene

Gene Ontology (GO) - Molecular Function for MIR424 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21885851
genes like me logo Genes that share ontologies with MIR424: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR424 Gene

Localization for MIR424 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR424 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR424 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25203061
genes like me logo Genes that share ontologies with MIR424: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR424 Gene

Pathways & Interactions for MIR424 Gene

PathCards logo

SuperPathways for MIR424 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR424 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001937 negative regulation of endothelial cell proliferation IDA 21885851
GO:0016525 negative regulation of angiogenesis IGI 28566713
GO:0035195 gene silencing by miRNA IDA 21885851
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway IGI 23263626
GO:0043537 negative regulation of blood vessel endothelial cell migration IGI 23263626
genes like me logo Genes that share ontologies with MIR424: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR424 Gene

Drugs & Compounds for MIR424 Gene

No Compound Related Data Available

Transcripts for MIR424 Gene

mRNA/cDNA for MIR424 Gene

4 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
5 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR424 Gene

No ASD Table

Relevant External Links for MIR424 Gene

GeneLoc Exon Structure for
MIR424

Expression for MIR424 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR424

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR424 Gene

Orthologs for MIR424 Gene

Evolution for MIR424 Gene

ENSEMBL:
Gene Tree for MIR424 (if available)
TreeFam:
Gene Tree for MIR424 (if available)

No data available for Orthologs for MIR424 Gene

Paralogs for MIR424 Gene

No data available for Paralogs for MIR424 Gene

Variants for MIR424 Gene

Additional dbSNP identifiers (rs#s) for MIR424 Gene

Additional Variant Information for MIR424 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR424

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR424 Gene

Disorders for MIR424 Gene

MalaCards: The human disease database

(47) MalaCards diseases for MIR424 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
leukemia, chronic lymphocytic
  • cll
intrahepatic cholangiocarcinoma
  • cholangiocarcinoma
endometriosis
senile angioma
  • senile hemangioma
skin hemangioma
  • angioma of the skin
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR424

genes like me logo Genes that share disorders with MIR424: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR424 Gene

Publications for MIR424 Gene

  1. The microRNAs miR-449a and miR-424 suppress osteosarcoma by targeting cyclin A2 expression. (PMID: 30679313) Shekhar R … Saxena S (The Journal of biological chemistry 2019) 3 54
  2. Expression levels of miR-143-3p and -424-5p in colorectal cancer and their clinical significance. (PMID: 30883340) Sahami-Fard MH … Sheikhha MH (Cancer biomarkers : section A of Disease markers 2019) 3 54
  3. miR-424-5p Regulates Hepatoma Cell Proliferation and Apoptosis. (PMID: 30676784) Piao L … Yu Q (Cancer biotherapy & radiopharmaceuticals 2019) 3 54
  4. MicroRNA-424-5p acts as a potential biomarker and inhibits proliferation and invasion in hepatocellular carcinoma by targeting TRIM29. (PMID: 30876939) Du H … Wu H (Life sciences 2019) 3 54
  5. Knockdown of lncRNA PVT1 Inhibits Glioma Progression by Regulating miR-424 Expression. (PMID: 30832754) Han Y … Ji X (Oncology research 2019) 3 54

Products for MIR424 Gene

Sources for MIR424 Gene