microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR423 Gene

Subcategory (RNA class) for MIR423 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR423 Gene

  • MIMAT0001340 50
  • MIMAT0004748 50
  • MI0001445 50
  • MIRN423 3
  • Mir-423 3
  • RF00870 168

External Ids for MIR423 Gene

Previous HGNC Symbols for MIR423 Gene

  • MIRN423

Previous GeneCards Identifiers for MIR423 Gene

  • GC17P025471
  • GC17P028444

Summaries for MIR423 Gene

Entrez Gene Summary for MIR423 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR423 Gene

MIR423 (MicroRNA 423) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR423 include Gastric Cancer and Intrinsic Cardiomyopathy. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR423 Gene

Additional gene information for MIR423 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR423 Gene

Genomics for MIR423 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR423 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J030116 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.4 422 3 BRCA1 ARHGAP35 HNRNPL CREB1 GATAD2A ATF7 PRDM10 ZNF629 REST IKZF1 ENSG00000265394 ENSG00000266919 NONHSAG021385.2 MN297430 MIR3184 MIR423 RF00017-2336 NSRP1 lnc-SLC6A4-7 piR-55704-002
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR423 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR423 Gene

Genomic Locations for MIR423 Gene
chr17:30,117,079-30,117,172
(GRCh38/hg38)
Size:
94 bases
Orientation:
Plus strand
chr17:28,444,097-28,444,190
(GRCh37/hg19)
Size:
94 bases
Orientation:
Plus strand

Genomic View for MIR423 Gene

Genes around MIR423 on UCSC Golden Path with GeneCards custom track
MIR423 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR423 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR423 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR423 Gene

Proteins for MIR423 Gene

Post-translational modifications for MIR423 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR423 Gene

Domains & Families for MIR423 Gene

Gene Families for MIR423 Gene

HGNC:
genes like me logo Genes that share domains with MIR423: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR423 Gene

Function for MIR423 Gene

Gene Ontology (GO) - Molecular Function for MIR423 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR423: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR423 Gene

Localization for MIR423 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR423 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR423 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR423: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR423 Gene

Pathways & Interactions for MIR423 Gene

PathCards logo

SuperPathways for MIR423 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR423: view

Pathways by source for MIR423 Gene

1 KEGG pathway for MIR423 Gene

Gene Ontology (GO) - Biological Process for MIR423 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
genes like me logo Genes that share ontologies with MIR423: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR423 Gene

Drugs & Compounds for MIR423 Gene

No Compound Related Data Available

Transcripts for MIR423 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR423 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00000BE495_9606 miRNA 23 6

RefSeq: NR_029945,

LncBase: hsa-miR-423-3p,

miRBase: MIMAT0001340,

MirGeneDB: Hsa-Mir-423_3p,

TarBase: hsa-miR-423-3p,

ENA: AY882274.1:1..23:ncRNA, LM379468.1:1..23:ncRNA, LM608933.1:53..75:ncRNA,

URS00001C8A86_9606 miRNA 23 6

RefSeq: NR_029945,

LncBase: hsa-miR-423-5p,

miRBase: MIMAT0004748,

MirGeneDB: Hsa-Mir-423_5p,

TarBase: hsa-miR-423-5p,

ENA: AY882281.1:1..23:ncRNA, LM380368.1:1..23:ncRNA, LM608933.1:17..39:ncRNA,

URS000075B951_9606 precursor_RNA 94 5

HGNC: 31880,

RefSeq: NR_029945,

Ensembl: ENST00000362201 (view in UCSC) ,

miRBase: MI0001445,

ENA: LM608933.1:1..94:precursor_RNA,

URS00006C130C_9606 precursor_RNA 81 1

Rfam: RF00870,

URS0000EFBC44_9606 precursor_RNA 60 1

MirGeneDB: Hsa-Mir-423,

MIR423 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR423 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR423 Gene

No ASD Table

Relevant External Links for MIR423 Gene

GeneLoc Exon Structure for
MIR423

Expression for MIR423 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR423

Evidence on tissue expression from TISSUES for MIR423 Gene

  • Blood(2.2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR423 Gene

Orthologs for MIR423 Gene

Evolution for MIR423 Gene

ENSEMBL:
Gene Tree for MIR423 (if available)
TreeFam:
Gene Tree for MIR423 (if available)

No data available for Orthologs for MIR423 Gene

Paralogs for MIR423 Gene

No data available for Paralogs for MIR423 Gene

Variants for MIR423 Gene

Additional dbSNP identifiers (rs#s) for MIR423 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR423 Gene

Variant ID Type Subtype PubMed ID
dgv5518n54 CNV loss 21841781

Additional Variant Information for MIR423 Gene

Human Gene Mutation Database (HGMD)
MIR423
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR423

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR423 Gene

Disorders for MIR423 Gene

MalaCards: The human disease database

(80) MalaCards diseases for MIR423 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
gastric cancer
  • gastric cancer, somatic
intrinsic cardiomyopathy
arteries, anomalies of
  • artery disease
intermediate coronary syndrome
  • angina at rest
heart septal defect
  • cardiac septal defects
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR423

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR423: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR423 Gene

Publications for MIR423 Gene

  1. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J … Wu X (Molecular carcinogenesis 2010) 3 41
  2. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J … Wu X (Carcinogenesis 2010) 3 41
  3. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T … Friedman E (International journal of cancer 2010) 3 41
  4. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y … Wu X (Cancer prevention research (Philadelphia, Pa.) 2008) 3 41
  5. Elevated pulmonary tuberculosis biomarker miR-423-5p plays critical role in the occurrence of active TB by inhibiting autophagosome-lysosome fusion. (PMID: 30898038) Tu H … Li J (Emerging microbes & infections 2019) 3

Products for MIR423 Gene

Sources for MIR423 Gene