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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR423 (MicroRNA 423) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR423 include Gastric Cancer and Intrinsic Cardiomyopathy. Among its related pathways are MicroRNAs in cancer.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH17J030116 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE CraniofacialAtlas | 600.7 | +0.4 | 422 | 3 | BRCA1 ARHGAP35 HNRNPL CREB1 GATAD2A ATF7 PRDM10 ZNF629 REST IKZF1 | ENSG00000265394 ENSG00000266919 NONHSAG021385.2 MN297430 MIR3184 MIR423 RF00017-2336 NSRP1 lnc-SLC6A4-7 piR-55704-002 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 20190813 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 26646931 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00000BE495_9606 | miRNA | 23 | 6 |
RefSeq: NR_029945, LncBase: hsa-miR-423-3p, miRBase: MIMAT0001340, MirGeneDB: Hsa-Mir-423_3p, TarBase: hsa-miR-423-3p, ENA: AY882274.1:1..23:ncRNA, LM379468.1:1..23:ncRNA, LM608933.1:53..75:ncRNA, |
URS00001C8A86_9606 | miRNA | 23 | 6 |
RefSeq: NR_029945, LncBase: hsa-miR-423-5p, miRBase: MIMAT0004748, MirGeneDB: Hsa-Mir-423_5p, TarBase: hsa-miR-423-5p, ENA: AY882281.1:1..23:ncRNA, LM380368.1:1..23:ncRNA, LM608933.1:17..39:ncRNA, |
URS000075B951_9606 | precursor_RNA | 94 | 5 |
HGNC: 31880, RefSeq: NR_029945, Ensembl: ENST00000362201 (view in UCSC) , miRBase: MI0001445, |
URS00006C130C_9606 | precursor_RNA | 81 | 1 |
Rfam: RF00870, |
URS0000EFBC44_9606 | precursor_RNA | 60 | 1 |
MirGeneDB: Hsa-Mir-423, |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv5518n54 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
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gastric cancer |
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intrinsic cardiomyopathy |
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arteries, anomalies of |
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intermediate coronary syndrome |
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heart septal defect |
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