microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR421 Gene

Subcategory (RNA class) for MIR421 Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR421 Gene

  • MicroRNA 421 2 3 5
  • Hsa-Mir-421 2 3
  • Hsa-MiR-421 163 173
  • MIR421 2 5
  • Hsa-Mir-95-P2 178
  • MIMAT0003339 50
  • MI0003685 50
  • MIRN421 3

External Ids for MIR421 Gene

Previous HGNC Symbols for MIR421 Gene

  • MIRN421

Previous GeneCards Identifiers for MIR421 Gene

  • GC0XM073358
  • GC0XM073438

Summaries for MIR421 Gene

Entrez Gene Summary for MIR421 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR421 Gene

MIR421 (MicroRNA 421) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are DNA Damage Response and miRNAs involved in DNA damage response.

Additional gene information for MIR421 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR421 Gene

Genomics for MIR421 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR421 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ074246 Enhancer 1 Ensembl ENCODE 13.2 -32.5 -32540 9.2 GATAD2A PRDM10 FOXA1 ZIC2 DPF2 HDAC1 ZNF600 CEBPA CEBPB SP1 lnc-ZCCHC13-2 MIR374B MIR421 MIR374A MIR545 FTX JPX piR-44727-008 ZCCHC13 RF00017-8527
GH0XJ074240 Enhancer 0.9 Ensembl ENCODE 13.3 -24.0 -23965 3 GATAD2A TFE3 RCOR2 RXRB IRF2 SP1 CEBPA SOX13 TCF7 TCF7L2 RF00017-8528 RN7SL648P lnc-ZCCHC13-3 MIR374B MIR421 FTX ZCCHC13 MIR374A MIR545 JPX
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR421 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR421 Gene

Genomic Locations for MIR421 Gene
chrX:74,218,377-74,218,461
(GRCh38/hg38)
Size:
85 bases
Orientation:
Minus strand
chrX:73,438,212-73,438,296
(GRCh37/hg19)
Size:
85 bases
Orientation:
Minus strand

Genomic View for MIR421 Gene

Genes around MIR421 on UCSC Golden Path with GeneCards custom track
MIR421 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR421 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR421 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR421 Gene

Proteins for MIR421 Gene

Post-translational modifications for MIR421 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR421 Gene

Domains & Families for MIR421 Gene

Gene Families for MIR421 Gene

genes like me logo Genes that share domains with MIR421: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR421 Gene

Function for MIR421 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR421 Gene

Localization for MIR421 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR421 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR421 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR421: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR421 Gene

Pathways & Interactions for MIR421 Gene

genes like me logo Genes that share pathways with MIR421: view

Pathways by source for MIR421 Gene

Gene Ontology (GO) - Biological Process for MIR421 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR421 Gene

Drugs & Compounds for MIR421 Gene

No Compound Related Data Available

Transcripts for MIR421 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR421 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075D018_9606 precursor_RNA 85 5

HGNC: 32793,

RefSeq: NR_030398,

Ensembl: ENST00000365696 (view in UCSC) ,

miRBase: MI0003685,

ENA: LM609601.1:1..85:precursor_RNA,

URS00004505E4_9606 miRNA 23 5

RefSeq: NR_030398,

LncBase: hsa-miR-421,

miRBase: MIMAT0003339,

TarBase: hsa-miR-421,

ENA: LM379897.1:1..23:ncRNA, LM609601.1:48..70:ncRNA,

URS0000EFC57C_9606 precursor_RNA 57 1

MirGeneDB: Hsa-Mir-95-P2,

URS0000D50E93_9606 miRNA 23 1

MirGeneDB: Hsa-Mir-95-P2_5p,

URS000075B4AD_9606 miRNA 22 1

MirGeneDB: Hsa-Mir-95-P2_3p,

MIR421 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR421 Gene

No ASD Table

Relevant External Links for MIR421 Gene

GeneLoc Exon Structure for
MIR421

No data available for mRNA/cDNA for MIR421 Gene

Expression for MIR421 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR421 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR421

genes like me logo Genes that share expression patterns with MIR421: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR421 Gene

Orthologs for MIR421 Gene

Evolution for MIR421 Gene

ENSEMBL:
Gene Tree for MIR421 (if available)
TreeFam:
Gene Tree for MIR421 (if available)

No data available for Orthologs for MIR421 Gene

Paralogs for MIR421 Gene

No data available for Paralogs for MIR421 Gene

Variants for MIR421 Gene

Additional dbSNP identifiers (rs#s) for MIR421 Gene

Additional Variant Information for MIR421 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR421

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR421 Gene

Disorders for MIR421 Gene

No disorders were found for MIR421 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR421 Gene

Publications for MIR421 Gene

  1. ATM is down-regulated by N-Myc-regulated microRNA-421. (PMID: 20080624) Hu H … Gatti RA (Proceedings of the National Academy of Sciences of the United States of America 2010) 2 3
  2. Circulating miR-421 Targeting Leucocytic Angiotensin Converting Enzyme 2 Is Elevated in Patients with Chronic Kidney Disease. (PMID: 30326474) Trojanowicz B … Girndt M (Nephron 2019) 3
  3. N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway. (PMID: 30657058) Yin Y … Huang J (Molecular cancer 2019) 3
  4. TFAP2E methylation promotes 5‑fluorouracil resistance via exosomal miR‑106a‑5p and miR‑421 in gastric cancer MGC‑803 cells. (PMID: 31115533) Jingyue S … Hong X (Molecular medicine reports 2019) 3
  5. Development of Response Classifier for Vascular Endothelial Growth Factor Receptor (VEGFR)-Tyrosine Kinase Inhibitor (TKI) in Metastatic Renal Cell Carcinoma. (PMID: 28963640) Go H … Cho YM (Pathology oncology research : POR 2019) 3

Products for MIR421 Gene

Sources for MIR421 Gene