microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR410 Gene

Subcategory (RNA class) for MIR410 Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR410 Gene

  • MicroRNA 410 2 3 5
  • Hsa-Mir-410 2 3
  • MIR410 2 5
  • Hsa-Mir-154-P12 178
  • Hsa-MiR-410-3p 173
  • MIMAT0026558 50
  • MIMAT0002171 50
  • MI0002465 50
  • MIRN410 3
  • Mir-410 3
  • RF00641 168

External Ids for MIR410 Gene

Previous HGNC Symbols for MIR410 Gene

  • MIRN410

Previous GeneCards Identifiers for MIR410 Gene

  • GC14P100843
  • GC14P100933
  • GC14P101534
  • GC14P101562
  • GC14P101595
  • GC14P101634
  • GC14P101662
  • GC14P101696
  • GC14P101734
  • GC14P101774
  • GC14P101832
  • GC14P101972
  • GC14P102169
  • GC14P101276
  • GC14P101895
  • GC14P103628
  • GC14P103844
  • GC14P104121
  • GC14P104461
  • GC14P102209
  • GC14P102376
  • GC14P102556
  • GC14P102728
  • GC14P102898
  • GC14P103074
  • GC14P103270
  • GC14P103445

Summaries for MIR410 Gene

Entrez Gene Summary for MIR410 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR410 Gene

MIR410 (MicroRNA 410) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Alzheimers Disease.

Rfam classification for MIR410 Gene

Additional gene information for MIR410 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR410 Gene

Genomics for MIR410 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR410 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J101096 Enhancer 0.9 FANTOM5 Ensembl ENCODE 11.4 +32.4 32355 3.3 ATF7 KDM1A SPI1 ATF4 MAFK JUN POLR2A RTL1 ENSG00000230805 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154
GH14J101095 Enhancer 0.2 Ensembl 11.4 +29.8 29789 0.2 MIR410 MIR656 MEG9 MIR369 MIR409 MIR412 MIR541 MIR377 MIR154 MIR323B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR410 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR410 Gene

Genomic Locations for MIR410 Gene
chr14:101,065,912-101,065,991
(GRCh38/hg38)
Size:
80 bases
Orientation:
Plus strand
chr14:101,532,249-101,532,328
(GRCh37/hg19)
Size:
80 bases
Orientation:
Plus strand

Genomic View for MIR410 Gene

Genes around MIR410 on UCSC Golden Path with GeneCards custom track
MIR410 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR410 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR410 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR410 Gene

Proteins for MIR410 Gene

Post-translational modifications for MIR410 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR410 Gene

Domains & Families for MIR410 Gene

Gene Families for MIR410 Gene

genes like me logo Genes that share domains with MIR410: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR410 Gene

Function for MIR410 Gene

Gene Ontology (GO) - Molecular Function for MIR410 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 23246289
genes like me logo Genes that share ontologies with MIR410: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR410 Gene

Localization for MIR410 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR410 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR410 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR410: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR410 Gene

Pathways & Interactions for MIR410 Gene

PathCards logo

SuperPathways for MIR410 Gene

SuperPathway Contained pathways
1 Alzheimers Disease
genes like me logo Genes that share pathways with MIR410: view

Pathways by source for MIR410 Gene

1 BioSystems pathway for MIR410 Gene

Gene Ontology (GO) - Biological Process for MIR410 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IMP 23246289
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IDA 28122380
GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IDA 28122380
genes like me logo Genes that share ontologies with MIR410: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR410 Gene

Drugs & Compounds for MIR410 Gene

No Compound Related Data Available

Transcripts for MIR410 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR410 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000717C38_9606 precursor_RNA 80 6

HGNC: 32065,

RefSeq: NR_030156,

Ensembl: ENST00000362222 (view in UCSC) ,

miRBase: MI0002465,

Rfam: RF00641,

ENA: LM609399.1:1..80:precursor_RNA,

URS000047E765_9606 miRNA 21 5

RefSeq: NR_030156,

miRBase: MIMAT0002171,

MirGeneDB: Hsa-Mir-154-P12_3p,

TarBase: hsa-miR-410-3p,

ENA: AY882266.1:1..21:ncRNA, LM379705.1:1..21:ncRNA, LM609399.1:50..70:ncRNA,

URS00002233F4_9606 miRNA 21 4

RefSeq: NR_030156,

miRBase: MIMAT0026558,

MirGeneDB: Hsa-Mir-154-P12_5p,

ENA: LM609399.1:14..34:ncRNA,

URS0000EFE52D_9606 precursor_RNA 58 1

MirGeneDB: Hsa-Mir-154-P12,

MIR410 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR410 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR410 Gene

No ASD Table

Relevant External Links for MIR410 Gene

GeneLoc Exon Structure for
MIR410

Expression for MIR410 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR410 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR410

genes like me logo Genes that share expression patterns with MIR410: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR410 Gene

Orthologs for MIR410 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR410 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-410 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-410 31
  • 95 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir410 31
  • 94 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-410 31
  • 65 (a)
OneToOne
Species where no ortholog for MIR410 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR410 Gene

ENSEMBL:
Gene Tree for MIR410 (if available)
TreeFam:
Gene Tree for MIR410 (if available)

Paralogs for MIR410 Gene

No data available for Paralogs for MIR410 Gene

Variants for MIR410 Gene

Additional dbSNP identifiers (rs#s) for MIR410 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR410 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv509551 CNV insertion 20534489
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Additional Variant Information for MIR410 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR410

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR410 Gene

Disorders for MIR410 Gene

No disorders were found for MIR410 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR410 Gene

Publications for MIR410 Gene

  1. Long non-coding RNA NEAT1 promotes bladder progression through regulating miR-410 mediated HMGB1. (PMID: 31734579) Shan G … Qian HJ (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020) 3
  2. Metalloproteinase 14 (MMP-14) and hsa-miR-410-3p expression in human inflamed dental pulp and odontoblasts. (PMID: 31486923) Brodzikowska A … Włodarski P (Histochemistry and cell biology 2019) 3
  3. Lineage-dependent role of miR-410-3p as oncomiR in gonadotroph and corticotroph pituitary adenomas or tumor suppressor miR in somatotroph adenomas via MAPK, PTEN/AKT, and STAT3 signaling pathways. (PMID: 31165412) Grzywa TM … Włodarski PK (Endocrine 2019) 3
  4. miR-410-3p regulates proliferation and apoptosis of fibroblast-like synoviocytes by targeting YY1 in rheumatoid arthritis. (PMID: 31505424) Wang Y … Zhang N (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3
  5. MiR-410 exerts neuroprotective effects in a cellular model of Parkinson's disease induced by 6-hydroxydopamine via inhibiting the PTEN/AKT/mTOR signaling pathway. (PMID: 31067440) Ge H … Zhao H (Experimental and molecular pathology 2019) 3

Products for MIR410 Gene

Sources for MIR410 Gene