microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR409 Gene

Subcategory (RNA class) for MIR409 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR409 Gene

  • MicroRNA 409 2 3 5
  • Hsa-MiR-409-5p 163 173
  • Hsa-MiR-409-3p 163 173
  • Hsa-Mir-409 2 3
  • MIR409 2 5
  • Hsa-Mir-154-P36 178
  • MIMAT0001639 50
  • MIMAT0001638 50
  • MI0001735 50
  • MIRN409 3
  • Mir-409 3
  • RF00641 168

External Ids for MIR409 Gene

Previous HGNC Symbols for MIR409 Gene

  • MIRN409

Previous GeneCards Identifiers for MIR409 Gene

  • GC14P100840
  • GC14P100930
  • GC14P101531
  • GC14P101273
  • GC14P101889
  • GC14P103627
  • GC14P103843
  • GC14P104120
  • GC14P104460
  • GC14P102205
  • GC14P102373
  • GC14P102552
  • GC14P102725
  • GC14P102895
  • GC14P103071
  • GC14P103267
  • GC14P103444

Summaries for MIR409 Gene

Entrez Gene Summary for MIR409 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR409 Gene

MIR409 (MicroRNA 409) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR409 include Pancreatitis, Hereditary and Dermatomyositis. Among its related pathways are Parkinsons Disease Pathway.

Rfam classification for MIR409 Gene

Additional gene information for MIR409 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR409 Gene

Genomics for MIR409 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR409 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J101096 Enhancer 0.9 FANTOM5 Ensembl ENCODE 11.4 +33.0 32967 3.3 ATF7 KDM1A SPI1 ATF4 MAFK JUN POLR2A RTL1 ENSG00000230805 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154
GH14J101095 Enhancer 0.2 Ensembl 11.4 +30.4 30401 0.2 MIR410 MIR656 MEG9 MIR369 MIR409 MIR412 MIR541 MIR377 MIR154 MIR323B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR409 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR409 Gene

Genomic Locations for MIR409 Gene
chr14:101,065,300-101,065,378
(GRCh38/hg38)
Size:
79 bases
Orientation:
Plus strand
chr14:101,531,637-101,531,715
(GRCh37/hg19)
Size:
79 bases
Orientation:
Plus strand

Genomic View for MIR409 Gene

Genes around MIR409 on UCSC Golden Path with GeneCards custom track
MIR409 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR409 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR409 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR409 Gene

Proteins for MIR409 Gene

Post-translational modifications for MIR409 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR409 Gene

Domains & Families for MIR409 Gene

Gene Families for MIR409 Gene

genes like me logo Genes that share domains with MIR409: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR409 Gene

Function for MIR409 Gene

Gene Ontology (GO) - Molecular Function for MIR409 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20570858
genes like me logo Genes that share ontologies with MIR409: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR409 Gene

Localization for MIR409 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR409 gene
Compartment Confidence
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR409 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR409: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR409 Gene

Pathways & Interactions for MIR409 Gene

PathCards logo

SuperPathways for MIR409 Gene

SuperPathway Contained pathways
1 Parkinsons Disease Pathway
genes like me logo Genes that share pathways with MIR409: view

Pathways by source for MIR409 Gene

1 BioSystems pathway for MIR409 Gene

Gene Ontology (GO) - Biological Process for MIR409 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0061754 negative regulation of circulating fibrinogen levels IDA 20570858
genes like me logo Genes that share ontologies with MIR409: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR409 Gene

Drugs & Compounds for MIR409 Gene

No Compound Related Data Available

Transcripts for MIR409 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR409 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000081E1F_9606 miRNA 23 6

RefSeq: NR_029975,

LncBase: hsa-miR-409-5p,

miRBase: MIMAT0001638,

MirGeneDB: Hsa-Mir-154-P36_5p,

TarBase: hsa-miR-409-5p,

ENA: LM379541.1:1..23:ncRNA, LM609036.1:15..37:ncRNA,

URS00002915C8_9606 miRNA 22 6

RefSeq: NR_029975,

LncBase: hsa-miR-409-3p,

miRBase: MIMAT0001639,

MirGeneDB: Hsa-Mir-154-P36_3p,

TarBase: hsa-miR-409-3p,

ENA: LM379542.1:1..22:ncRNA, LM609036.1:47..68:ncRNA,

URS0000759A5D_9606 precursor_RNA 79 5

HGNC: 32055,

RefSeq: NR_029975,

Ensembl: ENST00000362237 (view in UCSC) ,

miRBase: MI0001735,

ENA: LM609036.1:1..79:precursor_RNA,

URS00004D42DB_9606 precursor_RNA 77 1

Rfam: RF00641,

URS0000EFCF77_9606 precursor_RNA 55 1

MirGeneDB: Hsa-Mir-154-P36,

MIR409 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR409 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR409 Gene

No ASD Table

Relevant External Links for MIR409 Gene

GeneLoc Exon Structure for
MIR409

Expression for MIR409 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR409 Gene

genes like me logo Genes that share expression patterns with MIR409: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR409 Gene

Orthologs for MIR409 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR409 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-409 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-409b 31
  • 76 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-409 31
  • 76 (a)
OneToOne
Species where no ortholog for MIR409 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR409 Gene

ENSEMBL:
Gene Tree for MIR409 (if available)
TreeFam:
Gene Tree for MIR409 (if available)

Paralogs for MIR409 Gene

No data available for Paralogs for MIR409 Gene

Variants for MIR409 Gene

Additional dbSNP identifiers (rs#s) for MIR409 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR409 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv509551 CNV insertion 20534489
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Additional Variant Information for MIR409 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR409

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR409 Gene

Disorders for MIR409 Gene

MalaCards: The human disease database

(17) MalaCards diseases for MIR409 Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
pancreatitis, hereditary
  • cp
dermatomyositis
  • amyopathic dermatomyositis
nemaline myopathy
  • nm
muscular dystrophy, duchenne type
  • dmd
paranasal sinus cancer
  • adenoid cystic carcinoma of accessory sinus
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR409: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR409 Gene

Publications for MIR409 Gene

  1. MicroRNA‑409 may function as a tumor suppressor in endometrial carcinoma cells by targeting Smad2. (PMID: 30431090) Zhang C … Wu L (Molecular medicine reports 2019) 3
  2. The role of miR-409-3p in regulation of HPV16/18-E6 mRNA in human cervical high-grade squamous intraepithelial lesions. (PMID: 30711417) Sommerova L … Hrstka R (Antiviral research 2019) 3
  3. Phosphoinositide-dependent kinase 1-associated glycolysis is regulated by miR-409-3p in clear cell renal cell carcinoma. (PMID: 30218446) Wang Y … Lv P (Journal of cellular biochemistry 2019) 3
  4. LncRNA ZEB1-AS1/miR-409-3p/ZEB1 feedback loop is involved in the progression of non-small cell lung cancer. (PMID: 30448056) Qu R … Zhang C (Biochemical and biophysical research communications 2018) 3
  5. MicroRNA-409 inhibits the proliferative ability of cervical carcinoma cells by regulating AKT. (PMID: 29509241) Li B … Shang LX (European review for medical and pharmacological sciences 2018) 3

Products for MIR409 Gene

Sources for MIR409 Gene