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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR3960 (MicroRNA 3960) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and Signaling by GPCR.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH09J127775 | Promoter/Enhancer | 2.7 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.7 | -3.1 | -3105 | 14.3 | SP1 CTCF PRDM10 ZNF629 RFX1 SIX5 LEF1 IKZF1 KDM1A ZNF692 | SH2D3C CDK9 lnc-CDK9-1 FPGS LOC102723566 SNORA65 RPL12 URM1 ZNF79 ENSG00000228510 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | HIV Transcription Elongation | ||
2 | HIV Life Cycle |
.91
.65
|
.45
|
3 | Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer | ||
4 | Gene Expression |
.48
|
|
5 | MicroRNAs in cardiomyocyte hypertrophy |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075CBCF_9606 | precursor_RNA | 91 | 4 |
HGNC: 41595, RefSeq: NR_039767, Ensembl: ENST00000583311 (view in UCSC) , miRBase: MI0016964, |
URS00003783AB_9606 | miRNA | 20 | 3 |
RefSeq: NR_039767, miRBase: MIMAT0019337, TarBase: hsa-miR-3960, |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv12879n54 | CNV | loss | 21841781 |
esv3891727 | CNV | gain | 25118596 |
nsv1075676 | CNV | deletion | 25765185 |
nsv466573 | CNV | loss | 19166990 |
nsv466575 | CNV | loss | 19166990 |
nsv471323 | CNV | loss | 18288195 |
nsv615371 | CNV | loss | 21841781 |
nsv615373 | CNV | loss | 21841781 |
nsv615374 | CNV | loss | 21841781 |
nsv825094 | CNV | gain | 20364138 |
No disorders were found for MIR3960 Gene.