microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR3911 Gene

Data sources for MIR3911 Gene:

Subcategory (RNA class) for MIR3911 Gene

miRNA

Aliases for MIR3911 Gene

External Ids for MIR3911 Gene

Previous GeneCards Identifiers for MIR3911 Gene

  • GC09U901633
  • GC09M130454

Summaries for MIR3911 Gene

Entrez Gene Summary for MIR3911 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3911 Gene

MIR3911 (MicroRNA 3911) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR3911 include Non-Syndromic Intellectual Disability and Ohtahara Syndrome.

Additional gene information for MIR3911 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR3911 Gene

Genomics for MIR3911 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR3911 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J127689 Enhancer 0.6 ENCODE dbSUPER 250.7 +1.3 1316 0.5 MAFF ZNF316 MAFK MAFG EMSY ENSG00000279571 MIR3911 TTC16 PTRH1 STXBP1 NIBAN2 RF00017-7930 CFAP157
GH09J127682 Enhancer 0.8 Ensembl ENCODE dbSUPER 0.4 +6.7 6677 2.5 MAFF ZNF316 MAFK DPF2 FOS CEBPB EMSY CFAP157 TTC16 NIBAN2 TOR2A MIR3911 RF00017-7930 STXBP1
GH09J127678 Enhancer 0.3 dbSUPER 0.4 +11.4 11379 2.4 EGR2 ZFHX2 RF00017-7930 MIR3911 CFAP157 STXBP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR3911 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR3911 Gene

Latest Assembly
chr9:127,690,687-127,690,795
(GRCh38/hg38)
Size:
109 bases
Orientation:
Minus strand

Previous Assembly
chr9:130,452,966-130,453,074
(GRCh37/hg19 by Entrez Gene)
Size:
109 bases
Orientation:
Minus strand

Genomic View for MIR3911 Gene

Genes around MIR3911 on UCSC Golden Path with GeneCards custom track
MIR3911 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR3911 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3911 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3911 Gene

Proteins for MIR3911 Gene

Post-translational modifications for MIR3911 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3911 Gene

Domains & Families for MIR3911 Gene

Gene Families for MIR3911 Gene

HGNC:
genes like me logo Genes that share domains with MIR3911: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR3911 Gene

Function for MIR3911 Gene

Phenotypes From GWAS Catalog for MIR3911 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3911 Gene

Localization for MIR3911 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR3911 Gene

Pathways & Interactions for MIR3911 Gene

PathCards logo

SuperPathways for MIR3911 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR3911 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR3911 Gene

Drugs & Compounds for MIR3911 Gene

No Compound Related Data Available

Transcripts for MIR3911 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR3911 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075C684_9606 precursor_RNA 109 4

RefSeq: NR_037473,

Ensembl: ENST00000577791 (view in UCSC) ,

miRBase: MI0016415,

ENA: LM611247.1:1..109:precursor_RNA,

URS00001B968D_9606 miRNA 22 3

RefSeq: NR_037473,

miRBase: MIMAT0018185,

ENA: FR772812.1:1..22:ncRNA, LM382169.1:1..22:ncRNA, LM611247.1:12..33:ncRNA,

MIR3911 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR3911 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3911 Gene

No ASD Table

Relevant External Links for MIR3911 Gene

GeneLoc Exon Structure for
MIR3911

Expression for MIR3911 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR3911 Gene

mRNA differential expression in normal tissues according to GTEx for MIR3911 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.3), Brain - Cerebellum (x5.8), Brain - Frontal Cortex (BA9) (x5.0), and Brain - Cortex (x4.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR3911

genes like me logo Genes that share expression patterns with MIR3911: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR3911 Gene

Orthologs for MIR3911 Gene

Evolution for MIR3911 Gene

ENSEMBL:
Gene Tree for MIR3911 (if available)
TreeFam:
Gene Tree for MIR3911 (if available)

No data available for Orthologs for MIR3911 Gene

Paralogs for MIR3911 Gene

No data available for Paralogs for MIR3911 Gene

Variants for MIR3911 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR3911 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs1135401819 Likely Pathogenic: Non-syndromic intellectual disability 127,690,778(-) C/T
NM_001032221.4(STXBP1):c.1706C>T (p.Ser569Phe)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR3911 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for MIR3911 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3911

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR3911 Gene

Disorders for MIR3911 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIR3911 Gene - From: CVR and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR3911

genes like me logo Genes that share disorders with MIR3911: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR3911 Gene

Publications for MIR3911 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
  3. Discovery of novel microRNAs in female reproductive tract using next generation sequencing. (PMID: 20224791) Creighton CJ … Gunaratne PH (PloS one 2010) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR3911 Gene

Sources for MIR3911 Gene