microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR383 Gene

RNA type for MIR383 Gene

miRNA

Aliases for MIR383 Gene

External Ids for MIR383 Gene

Previous HGNC Symbols for MIR383 Gene

  • MIRN383

Previous GeneCards Identifiers for MIR383 Gene

  • GC08M014757
  • GC08M014710

Summaries for MIR383 Gene

Entrez Gene Summary for MIR383 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR383 Gene

MIR383 (MicroRNA 383) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR383 include Pancreatitis, Hereditary and Embryonal Testis Carcinoma.

Rfam classification for MIR383 Gene

Additional gene information for MIR383 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR383 Gene

Genomics for MIR383 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR383 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J014802 Enhancer 0.3 ENCODE 11.6 +50.7 50676 1 POLR2A NANOG piR-33432-491 piR-57176-603 MIR383 HSALNG0063578 SGCZ
GH08J014801 Enhancer 0.2 ENCODE 11.6 +51.5 51543 0.2 MIR383 piR-57176-603 HSALNG0063578 SGCZ
GH08J014844 Enhancer 0.2 Ensembl 0.4 +8.6 8609 0.6 MIR383 RF00017-6305 SGCZ
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR383 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR383 Gene

Latest Assembly
chr8:14,853,438-14,853,510
(GRCh38/hg38)
Size:
73 bases
Orientation:
Minus strand

Previous Assembly
chr8:14,710,947-14,711,019
(GRCh37/hg19 by Entrez Gene)
Size:
73 bases
Orientation:
Minus strand

chr8:14,710,947-14,711,019
(GRCh37/hg19 by Ensembl)
Size:
73 bases
Orientation:
Minus strand

Genomic View for MIR383 Gene

Genes around MIR383 on UCSC Golden Path with GeneCards custom track
MIR383 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR383 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR383 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR383 Gene

Proteins for MIR383 Gene

Post-translational modifications for MIR383 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR383 Gene

Domains & Families for MIR383 Gene

Gene Families for MIR383 Gene

HGNC:
genes like me logo Genes that share domains with MIR383: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR383 Gene

Function for MIR383 Gene

Phenotypes From GWAS Catalog for MIR383 Gene

Gene Ontology (GO) - Molecular Function for MIR383 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 31648164
genes like me logo Genes that share ontologies with MIR383: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR383 Gene

Localization for MIR383 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR383 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR383 Gene

Pathways & Interactions for MIR383 Gene

PathCards logo

SuperPathways for MIR383 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR383 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032700 negative regulation of interleukin-17 production IDA 31648164
GO:0035195 gene silencing by miRNA IDA,IEA --
genes like me logo Genes that share ontologies with MIR383: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR383 Gene

Drugs & Compounds for MIR383 Gene

No Compound Related Data Available

Transcripts for MIR383 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR383 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00000C5969_9606 miRNA 22 6

RefSeq: NR_029875,

LncBase: hsa-miR-383-5p,

miRBase: MIMAT0000738,

MirGeneDB: Hsa-Mir-383-v1_5p,

TarBase: hsa-miR-383-5p,

ENA: LM379243.1:1..22:ncRNA, LM608709.1:7..28:ncRNA,

URS00004A6370_9606 pre_miRNA 73 5

RefSeq: NR_029875,

Ensembl: ENST00000362257 (view in UCSC) ,

miRBase: MI0000791,

Rfam: RF00715,

ENA: LM608709.1:1..73:precursor_RNA,

URS000075B780_9606 miRNA 19 3

RefSeq: NR_029875,

miRBase: MIMAT0026485,

ENA: LM608709.1:50..68:ncRNA,

URS0000406128_9606 miRNA 21 2

MirGeneDB: Hsa-Mir-383-v1_3p, Hsa-Mir-383-v2_3p,

ENA: AY940874.1:1..21:ncRNA,

URS0001BC2185_9606 pre_miRNA 73 1

Rfam: RF00715,

MIR383 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR383 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR383 Gene

No ASD Table

Relevant External Links for MIR383 Gene

GeneLoc Exon Structure for
MIR383

Expression for MIR383 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR383

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR383 Gene

Orthologs for MIR383 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR383 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia cfa-mir-383 30
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-383 30
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-383 30
  • 99 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir383 30
  • 96 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-383 30
  • 89 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-383 30
  • 57 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-383 30
  • 95 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-383 30
  • 60 (a)
OneToOne
Species where no ortholog for MIR383 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR383 Gene

ENSEMBL:
Gene Tree for MIR383 (if available)
TreeFam:
Gene Tree for MIR383 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR383

Paralogs for MIR383 Gene

No data available for Paralogs for MIR383 Gene

Variants for MIR383 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR383 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR383 Gene

Variant ID Type Subtype PubMed ID
dgv12007n54 CNV gain 21841781
dgv248e55 CNV loss 17911159
esv2759598 CNV loss 17122850
esv3616376 CNV loss 21293372
esv3616377 CNV loss 21293372
esv3891347 CNV gain+loss 25118596
nsv1024069 CNV gain 25217958
nsv437049 CNV loss 16327808
nsv438041 CNV loss 16468122
nsv465541 CNV gain 19166990
nsv469745 CNV loss 16826518
nsv610466 CNV loss 21841781
nsv818605 CNV loss 17921354
nsv8298 CNV gain+loss 18304495

Additional Variant Information for MIR383 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR383
Leiden Open Variation Database (LOVD)
MIR383

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR383 Gene

Disorders for MIR383 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR383 Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
pancreatitis, hereditary
  • pctt
embryonal testis carcinoma
  • embryonal carcinoma of testis
medulloblastoma
  • mdb
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR383

genes like me logo Genes that share disorders with MIR383: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR383 Gene

Publications for MIR383 Gene

  1. MicroRNA -383-5p restrains the proliferation and migration of breast cancer cells and promotes apoptosis via inhibition of PD-L1. (PMID: 33359245) Azarbarzin S … Safaralizadeh R (Life sciences 2021) 3
  2. Identification of regulatory mRNA and microRNA for differentiation into cementoblasts and periodontal ligament cells. (PMID: 32797637) Iwata T … Kurihara H (Journal of periodontal research 2021) 3
  3. RP11-284F21.9 promotes oral squamous cell carcinoma development via the miR-383-5p/MAL2 axis. (PMID: 31397491) Shao B … Gan N (Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2020) 3
  4. Expression and clinical diagnostic value of miR-383 in patients with severe preeclampsia. (PMID: 32538753) Li T … Li Y (Cellular and molecular biology (Noisy-le-Grand, France) 2020) 3
  5. miR-383 ameliorates high glucose-induced β-cells apoptosis and hyperglycemia in high-fat induced diabetic mice. (PMID: 33058915) Cheng X … Bu L (Life sciences 2020) 3

Products for MIR383 Gene

Sources for MIR383 Gene