microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR381 Gene

Subcategory (RNA class) for MIR381 Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR381 Gene

  • MicroRNA 381 2 3 5
  • Hsa-Mir-381 2 3
  • MIR381 2 5
  • Hsa-MiR-381-3p 173
  • Hsa-Mir-154-P9 178
  • MIMAT0000736 50
  • MIMAT0022862 50
  • MI0000789 50
  • MIRN381 3
  • Mir-381 3
  • RF00641 168

External Ids for MIR381 Gene

Previous HGNC Symbols for MIR381 Gene

  • MIRN381

Previous GeneCards Identifiers for MIR381 Gene

  • GC14P100824
  • GC14P100914
  • GC14P101515
  • GC14P101544
  • GC14P101577
  • GC14P101618
  • GC14P101646
  • GC14P101679
  • GC14P101717
  • GC14P101759
  • GC14P101817
  • GC14P101957
  • GC14P102153
  • GC14P101256
  • GC14P101866
  • GC14P103624
  • GC14P103840
  • GC14P104114
  • GC14P104457
  • GC14P102116
  • GC14P102354
  • GC14P102525
  • GC14P102704
  • GC14P102872
  • GC14P103049
  • GC14P103246
  • GC14P103441

Summaries for MIR381 Gene

Entrez Gene Summary for MIR381 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR381 Gene

MIR381 (MicroRNA 381) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR381 include Inclusion Body Myositis and Muscular Dystrophy, Duchenne Type. Among its related pathways are Alzheimers Disease.

Rfam classification for MIR381 Gene

Additional gene information for MIR381 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR381 Gene

Genomics for MIR381 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR381 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR381 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR381 Gene

Genomic Locations for MIR381 Gene
chr14:101,045,918-101,045,996
(GRCh38/hg38)
Size:
79 bases
Orientation:
Plus strand
chr14:101,512,257-101,512,331
(GRCh37/hg19)
Size:
75 bases
Orientation:
Plus strand

Genomic View for MIR381 Gene

Genes around MIR381 on UCSC Golden Path with GeneCards custom track
MIR381 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR381 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR381 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR381 Gene

Proteins for MIR381 Gene

Post-translational modifications for MIR381 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR381 Gene

Domains & Families for MIR381 Gene

Gene Families for MIR381 Gene

genes like me logo Genes that share domains with MIR381: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR381 Gene

Function for MIR381 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR381 Gene

Localization for MIR381 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR381 gene
Compartment Confidence
extracellular 2
cytoskeleton 2
nucleus 2
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR381 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR381: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR381 Gene

Pathways & Interactions for MIR381 Gene

PathCards logo

SuperPathways for MIR381 Gene

SuperPathway Contained pathways
1 Alzheimers Disease
genes like me logo Genes that share pathways with MIR381: view

Pathways by source for MIR381 Gene

1 BioSystems pathway for MIR381 Gene

Gene Ontology (GO) - Biological Process for MIR381 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR381: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR381 Gene

Drugs & Compounds for MIR381 Gene

No Compound Related Data Available

Transcripts for MIR381 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR381 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075A1A8_9606 precursor_RNA 75 5

HGNC: 31874,

RefSeq: NR_029873,

Ensembl: ENST00000362150 (view in UCSC) ,

miRBase: MI0000789,

ENA: LM608707.1:1..75:precursor_RNA,

URS00001FFA8C_9606 miRNA 22 5

RefSeq: NR_029873,

miRBase: MIMAT0000736,

MirGeneDB: Hsa-Mir-154-P9_3p,

TarBase: hsa-miR-381-3p,

ENA: AY785922.1:1..22:ncRNA, LM379241.1:1..22:ncRNA, LM608707.1:49..70:ncRNA,

URS00004A35E2_9606 miRNA 22 3

RefSeq: NR_029873,

miRBase: MIMAT0022862,

ENA: LM383059.1:1..22:ncRNA, LM608707.1:8..29:ncRNA,

URS00006ECD73_9606 precursor_RNA 79 1

Rfam: RF00641,

URS0000EFD56E_9606 precursor_RNA 64 1

MirGeneDB: Hsa-Mir-154-P9,

MIR381 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR381 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR381 Gene

No ASD Table

Relevant External Links for MIR381 Gene

GeneLoc Exon Structure for
MIR381

Expression for MIR381 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR381

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR381 Gene

Orthologs for MIR381 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR381 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-381 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-381 31
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-381 31
  • 92 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia mmu-mir-381 31
  • 83 (a)
OneToOne
Species where no ortholog for MIR381 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR381 Gene

ENSEMBL:
Gene Tree for MIR381 (if available)
TreeFam:
Gene Tree for MIR381 (if available)

Paralogs for MIR381 Gene

No data available for Paralogs for MIR381 Gene

Variants for MIR381 Gene

Additional dbSNP identifiers (rs#s) for MIR381 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR381 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Additional Variant Information for MIR381 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR381

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR381 Gene

Disorders for MIR381 Gene

MalaCards: The human disease database

(9) MalaCards diseases for MIR381 Gene - From: miR2Disease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR381

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR381: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR381 Gene

Publications for MIR381 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 41
  2. MiR-381-3p suppresses biological characteristics of cancer in head-neck squamous cell carcinoma cells by targeting nuclear autoantigenic sperm protein (NASP). (PMID: 31797734) Kong F … He S (Bioscience, biotechnology, and biochemistry 2020) 3
  3. miR-381 overcomes cisplatin resistance in breast cancer by targeting MDR1. (PMID: 30444043) Yi D … Sang J (Cell biology international 2019) 3
  4. Dual regulatory role of CCNA2 in modulating CDK6 and MET-mediated cell-cycle pathway and EMT progression is blocked by miR-381-3p in bladder cancer. (PMID: 30138038) Li J … Xie L (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019) 3
  5. miR‑381 and miR‑489 suppress cell proliferation and invasion by targeting CUL4B via the Wnt/β‑catenin pathway in gastric cancer. (PMID: 30483755) Fang Z … Xiang X (International journal of oncology 2019) 3

Products for MIR381 Gene

Sources for MIR381 Gene