microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR378J Gene

Data sources for MIR378J Gene:

Subcategory (RNA class) for MIR378J Gene

miRNA

Aliases for MIR378J Gene

External Ids for MIR378J Gene

Previous GeneCards Identifiers for MIR378J Gene

  • GC17U902057

Summaries for MIR378J Gene

Entrez Gene Summary for MIR378J Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR378J Gene

MIR378J (MicroRNA 378j) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR378J Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR378J Gene

Genomics for MIR378J Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR378J Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J037613 Enhancer 0.6 Ensembl ENCODE 250.7 +0.4 411 1.9 FEZF1 CEBPB FOS MIR378J DDX52 ENSG00000277688 SYNRG lnc-HNF1B-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR378J on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR378J Gene

Latest Assembly
chr17:37,614,931-37,615,039
(GRCh38/hg38)
Size:
109 bases
Orientation:
Minus strand

Previous Assembly
chr17:35,974,976-35,975,084
(GRCh37/hg19 by Entrez Gene)
Size:
109 bases
Orientation:
Minus strand

Genomic View for MIR378J Gene

Genes around MIR378J on UCSC Golden Path with GeneCards custom track
MIR378J in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR378J Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR378J Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR378J Gene

Proteins for MIR378J Gene

Post-translational modifications for MIR378J Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR378J Gene

Domains & Families for MIR378J Gene

Gene Families for MIR378J Gene

HGNC:
genes like me logo Genes that share domains with MIR378J: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR378J Gene

Function for MIR378J Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR378J Gene

Localization for MIR378J Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR378J Gene

Pathways & Interactions for MIR378J Gene

PathCards logo

SuperPathways for MIR378J Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR378J Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR378J Gene

Drugs & Compounds for MIR378J Gene

No Compound Related Data Available

Transcripts for MIR378J Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR378J Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075C0D8_9606 pre_miRNA 109 3

RefSeq: NR_106744,

Ensembl: ENST00000611988 (view in UCSC) ,

miRBase: MI0021273,

URS000075DCB5_9606 miRNA 19 2

RefSeq: NR_106744,

miRBase: MIMAT0024612,

MIR378J in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR378J Gene

No ASD Table

Relevant External Links for MIR378J Gene

GeneLoc Exon Structure for
MIR378J

No data available for mRNA/cDNA for MIR378J Gene

Expression for MIR378J Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR378J Gene

Orthologs for MIR378J Gene

Evolution for MIR378J Gene

ENSEMBL:
Gene Tree for MIR378J (if available)
TreeFam:
Gene Tree for MIR378J (if available)

No data available for Orthologs for MIR378J Gene

Paralogs for MIR378J Gene

No data available for Paralogs for MIR378J Gene

Variants for MIR378J Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR378J Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR378J Gene

Variant ID Type Subtype PubMed ID
nsv833431 CNV gain 17160897

Additional Variant Information for MIR378J Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR378J

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR378J Gene

Disorders for MIR378J Gene

Additional Disease Information for MIR378J

No disorders were found for MIR378J Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR378J Gene

Publications for MIR378J Gene

  1. Transcription factors are targeted by differentially expressed miRNAs in primates. (PMID: 22454130) Dannemann M … Kelso J (Genome biology and evolution 2012) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR378J Gene

Sources for MIR378J Gene