microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR378I Gene

Subcategory (RNA class) for MIR378I Gene

miRNA

Number of RNA Genes sources:

4 / 17

Aliases for MIR378I Gene

  • MicroRNA 378i 2 3 5
  • Hsa-Mir-378i 2 3
  • Hsa-MiR-378i 163 173
  • MIR378I 2 5
  • MIMAT0019074 50
  • MI0016902 50

External Ids for MIR378I Gene

Previous GeneCards Identifiers for MIR378I Gene

  • GC22U900799
  • GC22M042322
  • GC22M041926
  • GC22M041928
  • GC22M042797
  • GC22M042910
  • GC22M042962
  • GC22M044571
  • GC22M042059
  • GC22M042065
  • GC22M042337
  • GC22M042683

Summaries for MIR378I Gene

Entrez Gene Summary for MIR378I Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR378I Gene

MIR378I (MicroRNA 378i) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Innate Immune System and Cytokine Signaling in Immune system.

Additional gene information for MIR378I Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR378I Gene

Genomics for MIR378I Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR378I Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J041918 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 -1.1 -1102 10.8 SP1 CTCF ZBTB33 KDM1A ZNF692 POLR2A BACH1 LARP7 MTA2 ZNF143 TNFRSF13C MIR378I lnc-TNFRSF13C-1 NDUFA6 SMDT1 CYP2D8P CSDC2 CENPM SHISA8 HSALNG0135671
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR378I on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR378I Gene

Genomic Locations for MIR378I Gene
chr22:41,923,222-41,923,297
(GRCh38/hg38)
Size:
76 bases
Orientation:
Minus strand
chr22:42,319,226-42,319,301
(GRCh37/hg19)
Size:
76 bases
Orientation:
Minus strand

Genomic View for MIR378I Gene

Genes around MIR378I on UCSC Golden Path with GeneCards custom track
MIR378I in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR378I Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR378I Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR378I Gene

Proteins for MIR378I Gene

Post-translational modifications for MIR378I Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR378I Gene

Domains & Families for MIR378I Gene

Gene Families for MIR378I Gene

HGNC:
genes like me logo Genes that share domains with MIR378I: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR378I Gene

Function for MIR378I Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR378I Gene

Localization for MIR378I Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR378I gene
Compartment Confidence
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR378I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR378I: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR378I Gene

Pathways & Interactions for MIR378I Gene

No data available for Interacting Proteins and SIGNOR curated interactions for MIR378I Gene

Drugs & Compounds for MIR378I Gene

No Compound Related Data Available

Transcripts for MIR378I Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR378I Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075DA4C_9606 precursor_RNA 76 5

HGNC: 41620,

RefSeq: NR_039760,

Ensembl: ENST00000582688 (view in UCSC) ,

miRBase: MI0016902,

ENA: LM611352.1:1..76:precursor_RNA,

URS0000480E22_9606 miRNA 21 5

RefSeq: NR_039760,

LncBase: hsa-miR-378i,

miRBase: MIMAT0019074,

TarBase: hsa-miR-378i,

ENA: LM382444.1:1..21:ncRNA, LM611352.1:7..27:ncRNA,

MIR378I in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR378I Gene

No ASD Table

Relevant External Links for MIR378I Gene

GeneLoc Exon Structure for
MIR378I

No data available for mRNA/cDNA for MIR378I Gene

Expression for MIR378I Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR378I Gene

mRNA differential expression in normal tissues according to GTEx for MIR378I Gene

This gene is overexpressed in Spleen (x16.6), Small Intestine - Terminal Ileum (x9.4), and Whole Blood (x9.3).
genes like me logo Genes that share expression patterns with MIR378I: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR378I Gene

Orthologs for MIR378I Gene

Evolution for MIR378I Gene

ENSEMBL:
Gene Tree for MIR378I (if available)
TreeFam:
Gene Tree for MIR378I (if available)

No data available for Orthologs for MIR378I Gene

Paralogs for MIR378I Gene

No data available for Paralogs for MIR378I Gene

Variants for MIR378I Gene

Additional dbSNP identifiers (rs#s) for MIR378I Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR378I Gene

Variant ID Type Subtype PubMed ID
nsv1057208 CNV gain 25217958
nsv508736 CNV insertion 20534489
nsv589053 CNV loss 21841781
nsv955162 CNV deletion 24416366

Additional Variant Information for MIR378I Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR378I

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR378I Gene

Disorders for MIR378I Gene

Additional Disease Information for MIR378I

No disorders were found for MIR378I Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR378I Gene

Publications for MIR378I Gene

  1. Identification of the novel 3' UTR sequences of human IL-21 mRNA as potential targets of miRNAs. (PMID: 28798470) Enomoto Y … Miyajima A (Scientific reports 2017) 3
  2. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR378I Gene

Sources for MIR378I Gene