microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR378E Gene

Subcategory (RNA class) for MIR378E Gene

miRNA

Number of RNA Genes sources:

3 / 14

Aliases for MIR378E Gene

  • MicroRNA 378e 2 3 5
  • Hsa-Mir-378e 3
  • MIMAT0018927 51
  • Hsa-MiR-378e 177
  • MI0016750 51
  • Mir-378e 3
  • MIR378E 2

External Ids for MIR378E Gene

Previous GeneCards Identifiers for MIR378E Gene

  • GC05U901578
  • GC05P169457

Summaries for MIR378E Gene

Entrez Gene Summary for MIR378E Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR378E Gene

MIR378E (MicroRNA 378e) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR378E Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR378E Gene

Genomics for MIR378E Gene

GeneHancer (GH) Regulatory Elements for MIR378E Gene

Promoters and enhancers for MIR378E Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J170100 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.2 +72.0 72047 1.1 CTCF REST RAD21 SMC3 ATF3 ELF1 WRNIP1 ZNF654 TCF7L2 EGR1 FOXI1 MIR378E
GH05J170046 Enhancer 0.4 Ensembl CraniofacialAtlas 0.4 +18.0 18011 0.6 SMARCA4 MIR378E FOXI1 DOCK2
GH05J170070 Enhancer 0.6 Ensembl 0.3 +42.2 42213 0.2 CTCF CTBP1 YY1 ZBTB7A ZBTB33 E2F1 ZNF217 XRCC5 RAD21 KDM1A FOXI1 MIR378E DOCK2
GH05J170057 Enhancer 0.4 Ensembl 0.3 +28.6 28613 0.2 DPF2 GATA3 FOS CREB1 MIR378E FOXI1 DOCK2
GH05J170053 Enhancer 0.3 Ensembl 0.3 +25.7 25713 0.8 GATA2 POLR2A MIR378E FOXI1 DOCK2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR378E on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR378E Gene

Genomic Locations for MIR378E Gene
chr5:170,028,488-170,028,566
(GRCh38/hg38)
Size:
79 bases
Orientation:
Plus strand
chr5:169,455,492-169,455,570
(GRCh37/hg19)
Size:
79 bases
Orientation:
Plus strand

Genomic View for MIR378E Gene

Genes around MIR378E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR378E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR378E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR378E Gene

Proteins for MIR378E Gene

Post-translational modifications for MIR378E Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR378E Gene

Domains & Families for MIR378E Gene

Gene Families for MIR378E Gene

genes like me logo Genes that share domains with MIR378E: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR378E Gene

Function for MIR378E Gene

Phenotypes From GWAS Catalog for MIR378E Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR378E Gene

Localization for MIR378E Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR378E gene
Compartment Confidence
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR378E Gene

Pathways & Interactions for MIR378E Gene

PathCards logo

SuperPathways for MIR378E Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR378E Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR378E Gene

Drugs & Compounds for MIR378E Gene

No Compound Related Data Available

Transcripts for MIR378E Gene

mRNA/cDNA for MIR378E Gene

2 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 miRBase transcripts :
3 ENA transcripts :
1 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR378E Gene

No ASD Table

Relevant External Links for MIR378E Gene

GeneLoc Exon Structure for
MIR378E

Expression for MIR378E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR378E Gene

genes like me logo Genes that share expression patterns with MIR378E: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR378E Gene

Orthologs for MIR378E Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR378E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-378e 31
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 50 (a)
OneToMany
Species where no ortholog for MIR378E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR378E Gene

ENSEMBL:
Gene Tree for MIR378E (if available)
TreeFam:
Gene Tree for MIR378E (if available)

Paralogs for MIR378E Gene

No data available for Paralogs for MIR378E Gene

Variants for MIR378E Gene

Additional dbSNP identifiers (rs#s) for MIR378E Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR378E Gene

Variant ID Type Subtype PubMed ID
nsv600259 CNV loss 21841781

Additional Variant Information for MIR378E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR378E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR378E Gene

Disorders for MIR378E Gene

Additional Disease Information for MIR378E

No disorders were found for MIR378E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR378E Gene

Publications for MIR378E Gene

  1. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini AA … Barker JN (Nature communications 2014) 3 54
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 54
  3. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 54
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 54

Products for MIR378E Gene

Sources for MIR378E Gene