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Aliases for MIR378B Gene

Subcategory (RNA class) for MIR378B Gene


Quality Score for this RNA gene is


Aliases for MIR378B Gene

  • MicroRNA 378b 2 3 5
  • Hsa-Mir-378b 3

External Ids for MIR378B Gene

Previous GeneCards Identifiers for MIR378B Gene

  • GC03U901630
  • GC03P010371
  • GC03P010396
  • GC03P010440
  • GC03P010467
  • GC03P010493
  • GC03P010521
  • GC03P010550
  • GC03P010578

Summaries for MIR378B Gene

Entrez Gene Summary for MIR378B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR378B Gene

MIR378B (MicroRNA 378b) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR378B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR378B Gene

Genomics for MIR378B Gene

GeneHancer (GH) Regulatory Elements for MIR378B Gene

Promoters and enhancers for MIR378B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I010333 Enhancer 0.6 dbSUPER 0.8 +4.9 4877 3.5 CTCF PKNOX1 RFX1 RB1 REST ZIC2 RAD21 BCL11B BCL11A GLIS1 GHRLOS MIR378B GC03P010614 GC03M010355 ATP2B2
GH03I010346 Enhancer 0.9 ENCODE dbSUPER 0.4 +14.1 14123 0.1 CTCF ZNF654 TRIM22 SIN3A REST ZNF501 ZNF2 RAD21 CC2D1A KLF16 SEC13 MIR885 MIR378B GC03M010355 ATP2B2
GH03I010357 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.3 +27.6 27635 1.5 BCOR ZNF473 INSM2 KLF17 MAX ZMYM3 EBF1 ZIC2 ZKSCAN1 GLIS2 ENSG00000206567 THUMPD3 RPUSD3 GHRLOS GC03M010355 MIR378B ATP2B2
GH03I010344 Enhancer 0.8 ENCODE dbSUPER 0.4 +14.2 14213 0 CTCF TRIM22 SIN3A REST ZNF501 ZNF2 RAD21 CC2D1A KLF16 ARID2 SEC13 MIR885 MIR378B GC03M010355 ATP2B2
GH03I010370 Enhancer 0.9 ENCODE dbSUPER 0.3 +40.4 40403 0.2 HDAC1 BACH1 FOSL1 TCF12 CTBP1 ZNF316 VEZF1 CBFA2T2 FOS NFE2 MIR885 GC03M010355 MIR378B ATP2B2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR378B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR378B Gene

Genomic Locations for MIR378B Gene
57 bases
Plus strand

Genomic View for MIR378B Gene

Genes around MIR378B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR378B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR378B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR378B Gene

Proteins for MIR378B Gene

Post-translational modifications for MIR378B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR378B Gene

Domains & Families for MIR378B Gene

Gene Families for MIR378B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR378B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR378B Gene

Function for MIR378B Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR378B Gene

Localization for MIR378B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR378B Gene

Pathways & Interactions for MIR378B Gene

SuperPathways for MIR378B Gene

No Data Available

Interacting Proteins for MIR378B Gene

Gene Ontology (GO) - Biological Process for MIR378B Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR378B Gene

Drugs & Compounds for MIR378B Gene

No Compound Related Data Available

Transcripts for MIR378B Gene

mRNA/cDNA for MIR378B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR378B Gene

No ASD Table

Relevant External Links for MIR378B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR378B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR378B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR378B Gene:

genes like me logo Genes that share expression patterns with MIR378B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR378B Gene

Orthologs for MIR378B Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR378B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-378b 34
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 51 (a)
Species where no ortholog for MIR378B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR378B Gene

Gene Tree for MIR378B (if available)
Gene Tree for MIR378B (if available)

Paralogs for MIR378B Gene

No data available for Paralogs for MIR378B Gene

Variants for MIR378B Gene

Sequence variations from dbSNP and Humsavar for MIR378B Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1003608107 -- 10,328,541(+) G/A upstream_transcript_variant
rs1007582890 -- 10,329,808(+) C/T upstream_transcript_variant
rs1007768641 -- 10,328,360(+) T/C upstream_transcript_variant
rs1007964715 -- 10,329,407(+) A/G upstream_transcript_variant
rs1008058780 -- 10,330,074(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR378B Gene

Variant ID Type Subtype PubMed ID
dgv762e201 CNV deletion 23290073
esv4117 OTHER complex 18987735
nsv1073204 CNV deletion 25765185
nsv1121603 CNV deletion 24896259
nsv436362 CNV deletion 17901297
nsv436869 CNV insertion 17901297
nsv508903 CNV insertion 20534489

Additional Variant Information for MIR378B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR378B Gene

Disorders for MIR378B Gene

Additional Disease Information for MIR378B

No disorders were found for MIR378B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR378B Gene

Publications for MIR378B Gene

  1. Increased Proangiogenic Activity of Mobilized CD34+ Progenitor Cells of Patients With Acute ST-Segment-Elevation Myocardial Infarction: Role of Differential MicroRNA-378 Expression. (PMID: 28062497) Templin C … Landmesser U (Arteriosclerosis, thrombosis, and vascular biology 2017) 3 58
  2. Decreased expression of miR-378 correlates with tumor invasiveness and poor prognosis of patients with glioma. (PMID: 26261592) Li B … Tao B (International journal of clinical and experimental pathology 2015) 3 58
  3. Characterization of the Melanoma miRNAome by Deep Sequencing. (PMID: 20300190) Stark MS … Hayward NK (PloS one 2010) 3 58
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR378B Gene

Sources for MIR378B Gene

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