microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR377 Gene

Subcategory (RNA class) for MIR377 Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR377 Gene

  • MicroRNA 377 2 3 5
  • Hsa-MiR-377-5p 166 177
  • Hsa-MiR-377-3p 166 177
  • MIMAT0004689 51
  • MIMAT0000730 51
  • Hsa-Mir-377 3
  • MI0000785 51
  • Mir-377 3
  • MIRN377 3
  • RF00641 172
  • MIR377 2

External Ids for MIR377 Gene

Previous HGNC Symbols for MIR377 Gene

  • MIRN377

Previous GeneCards Identifiers for MIR377 Gene

  • GC14P100838
  • GC14P100928
  • GC14P101529
  • GC14P101559
  • GC14P101592
  • GC14P101631
  • GC14P101659
  • GC14P101693
  • GC14P101731
  • GC14P101771
  • GC14P101829
  • GC14P101969
  • GC14P102166
  • GC14P101271
  • GC14P101887
  • GC14P103619
  • GC14P103837
  • GC14P104111
  • GC14P102203
  • GC14P102371
  • GC14P102549
  • GC14P102723
  • GC14P102893
  • GC14P103069
  • GC14P103265
  • GC14P103438

Summaries for MIR377 Gene

Entrez Gene Summary for MIR377 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR377 Gene

MIR377 (MicroRNA 377) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR377 include Microvascular Complications Of Diabetes 3 and Ovarian Cancer. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

Rfam classification for MIR377 Gene

Additional gene information for MIR377 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR377 Gene

Genomics for MIR377 Gene

GeneHancer (GH) Regulatory Elements for MIR377 Gene

Promoters and enhancers for MIR377 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J101062 Enhancer 0.8 Ensembl ENCODE CraniofacialAtlas 500.7 +0.7 653 2.9 NR2F2 CTCF FOS GATA2 JUN RAD21 POLR2A ZNF316 MIR377 MIR541 MEG9
GH14J101096 Enhancer 0.9 FANTOM5 Ensembl ENCODE 11 +36.2 36222 3.3 KDM1A SPI1 FOS ATF4 GATA2 JUN POLR2A MAFK ZNF549 ATF7 RTL1 ENSG00000230805 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154
GH14J101232 Enhancer 0.9 Ensembl CraniofacialAtlas 9.6 +172.1 172055 3.4 CTCF ZIC2 REST GABPA RAD21 SMC3 SRSF1 MBD1 ELF1 SMAD4 MIR370 MIR655 MIR1185-2 MIR381 MIR487B MIR539 MIR544A MIR889 MIR1185-1 MIR300
GH14J101176 Enhancer 0.6 Ensembl ENCODE 10.7 +115.3 115321 2 MXI1 FOXP2 RCOR1 ZFP3 CHD2 ZNF680 MIR154 MIR377 MIR496 MIR134 MIR323B MIR485 MIR487A SNORD113-3 SNORD113-2 ENSG00000222185
GH14J101004 Enhancer 0.6 ENCODE CraniofacialAtlas 11 -57.0 -56960 1.9 SPI1 TCF7L2 GATA3 MYC MNT MIR134 MIR487A MIR154 MIR323B MIR485 MIR377 MIR496 MIR376C MIR1185-1 MIR1185-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR377 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR377 Gene

Genomic Locations for MIR377 Gene
chr14:101,062,045-101,062,124
(GRCh38/hg38)
Size:
80 bases
Orientation:
Plus strand
chr14:101,528,343-101,528,476
(GRCh37/hg19)
Size:
134 bases
Orientation:
Plus strand

Genomic View for MIR377 Gene

Genes around MIR377 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR377 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR377 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR377 Gene

Proteins for MIR377 Gene

Post-translational modifications for MIR377 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR377 Gene

Domains & Families for MIR377 Gene

Gene Families for MIR377 Gene

genes like me logo Genes that share domains with MIR377: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR377 Gene

Function for MIR377 Gene

Phenotypes From GWAS Catalog for MIR377 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR377 Gene

Localization for MIR377 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR377 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR377 Gene

Pathways & Interactions for MIR377 Gene

genes like me logo Genes that share pathways with MIR377: view

Pathways by source for MIR377 Gene

1 BioSystems pathway for MIR377 Gene
;

Gene Ontology (GO) - Biological Process for MIR377 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903671 negative regulation of sprouting angiogenesis IMP 25251394
genes like me logo Genes that share ontologies with MIR377: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR377 Gene

Drugs & Compounds for MIR377 Gene

No Compound Related Data Available

Transcripts for MIR377 Gene

mRNA/cDNA for MIR377 Gene

4 RNACentral transcripts :
1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
6 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR377 Gene

No ASD Table

Relevant External Links for MIR377 Gene

GeneLoc Exon Structure for
MIR377

Expression for MIR377 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR377 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR377

genes like me logo Genes that share expression patterns with MIR377: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR377 Gene

Orthologs for MIR377 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR377 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-377 31
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir377 31
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-377 31
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-377 31
  • 86 (a)
OneToOne
Species where no ortholog for MIR377 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR377 Gene

ENSEMBL:
Gene Tree for MIR377 (if available)
TreeFam:
Gene Tree for MIR377 (if available)

Paralogs for MIR377 Gene

No data available for Paralogs for MIR377 Gene

Variants for MIR377 Gene

Additional dbSNP identifiers (rs#s) for MIR377 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR377 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv509551 CNV insertion 20534489
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Additional Variant Information for MIR377 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR377

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR377 Gene

Disorders for MIR377 Gene

MalaCards: The human disease database

(8) MalaCards diseases for MIR377 Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
microvascular complications of diabetes 3
  • end-stage renal disease, diabetic
ovarian cancer
  • ovarian cancer, somatic
ampulla of vater cancer
  • malignant tumour of ampulla of vater
leiomyoma, uterine
  • ul
duodenum cancer
  • cancer of duodenum
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR377

genes like me logo Genes that share disorders with MIR377: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR377 Gene

Publications for MIR377 Gene

  1. Circular RNA circ-PRMT5 facilitates non-small cell lung cancer proliferation through upregulating EZH2 via sponging miR-377/382/498. (PMID: 31479715) Wang Y … Wang F (Gene 2019) 3 54
  2. MiR-377 inhibits wear particle-induced osteolysis via targeting RANKL. (PMID: 30958621) Li W … Wang F (Cell biology international 2019) 3 54
  3. Down-regulation of miR-377 suppresses high glucose and hypoxia-induced angiogenesis and inflammation in human retinal endothelial cells by direct up-regulation of target gene SIRT1. (PMID: 30706373) Cui C … Liu Y (Human cell 2019) 3 54
  4. MicroRNA-377 Targets Zinc Finger E-box-Binding Homeobox 2 to Inhibit Cell Proliferation and Invasion of Cervical Cancer. (PMID: 29523224) Ye C … Wang J (Oncology research 2019) 3 54
  5. The long non-coding RNA SNHG5 regulates gefitinib resistance in lung adenocarcinoma cells by targetting miR-377/CASP1 axis. (PMID: 29592872) Wang Z … Wang Y (Bioscience reports 2018) 3 54

Products for MIR377 Gene

Sources for MIR377 Gene