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Aliases for MIR377 Gene

Subcategory (RNA class) for MIR377 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR377 Gene

  • MicroRNA 377 2 3 5
  • Hsa-Mir-377 3
  • Mir-377 3
  • MIRN377 3

External Ids for MIR377 Gene

ORGUL Members for MIR377 Gene

Previous HGNC Symbols for MIR377 Gene

  • MIRN377

Previous GeneCards Identifiers for MIR377 Gene

  • GC14P100838
  • GC14P100928
  • GC14P101529
  • GC14P101559
  • GC14P101592
  • GC14P101631
  • GC14P101659
  • GC14P101693
  • GC14P101731
  • GC14P101771
  • GC14P101829
  • GC14P101969
  • GC14P102166
  • GC14P101271
  • GC14P101887
  • GC14P102203
  • GC14P102371
  • GC14P102549
  • GC14P102723
  • GC14P102893

Summaries for MIR377 Gene

Entrez Gene Summary for MIR377 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR377 Gene

MIR377 (MicroRNA 377) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

Additional gene information for MIR377 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR377 Gene

Genomics for MIR377 Gene

GeneHancer (GH) Regulatory Elements for MIR377 Gene

Promoters and enhancers for MIR377 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I101063 Enhancer 0.3 ENCODE 550.8 +1.6 1632 0.9 CTCF GC14M101064 GC14P103108 GC14P103120 GC14P103143 GC14P103153 GC14P103180 MIR369 MIR377 MIR409 MIR412
GH14I101096 Enhancer 0.7 FANTOM5 ENCODE 11 +36.3 36298 3.2 ATF4 POLR2A JUN MAFK RTL1 LOC105370670 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154
GH14I101004 Enhancer 0.7 Ensembl ENCODE 11 -57.0 -56965 1.9 GATA3 MNT MYC TCF7L2 MIR134 MIR487A MIR154 MIR323B MIR485 MIR377 MIR496 MIR376C MIR1185-1 MIR1185-2
GH14I101176 Enhancer 0.5 ENCODE 10.7 +115.3 115316 2 ZNF680 ZFP3 RCOR1 CHD2 MIR154 MIR377 MIR496 MIR134 MIR323B MIR485 MIR487A SNORD113-2 SNORD113-3 ENSG00000222185
GH14I101008 Enhancer 0.2 ENCODE 11 -53.4 -53351 0.2 MIR487A MIR134 MIR323B MIR485 MIR154 MIR377 MIR496 MIR1185-1 MIR300 MIR376C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR377 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR377 Gene

Genomic Locations for MIR377 Gene
chr14:101,062,050-101,062,118
(GRCh38/hg38)
Size:
69 bases
Orientation:
Plus strand
chr14:101,528,343-101,528,476
(GRCh37/hg19)

Genomic View for MIR377 Gene

Genes around MIR377 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR377 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR377 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR377 Gene

Proteins for MIR377 Gene

Post-translational modifications for MIR377 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR377 Gene

Domains & Families for MIR377 Gene

Gene Families for MIR377 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR377: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR377 Gene

Function for MIR377 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR377 Gene

Localization for MIR377 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR377 Gene

Pathways & Interactions for MIR377 Gene

genes like me logo Genes that share pathways with MIR377: view

Pathways by source for MIR377 Gene

1 BioSystems pathway for MIR377 Gene

Interacting Proteins for MIR377 Gene

Gene Ontology (GO) - Biological Process for MIR377 Gene

None

No data available for SIGNOR curated interactions for MIR377 Gene

Drugs & Compounds for MIR377 Gene

No Compound Related Data Available

Transcripts for MIR377 Gene

mRNA/cDNA for MIR377 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR377 Gene

No ASD Table

Relevant External Links for MIR377 Gene

GeneLoc Exon Structure for
MIR377
ECgene alternative splicing isoforms for
MIR377

Expression for MIR377 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR377 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR377 Gene:

MIR377
genes like me logo Genes that share expression patterns with MIR377: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR377 Gene

Orthologs for MIR377 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR377 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-377 34
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir377 34
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-377 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-377 34
  • 86 (a)
OneToOne
Species where no ortholog for MIR377 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR377 Gene

ENSEMBL:
Gene Tree for MIR377 (if available)
TreeFam:
Gene Tree for MIR377 (if available)

Paralogs for MIR377 Gene

No data available for Paralogs for MIR377 Gene

Variants for MIR377 Gene

Sequence variations from dbSNP and Humsavar for MIR377 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000523482 -- 101,061,897(+) C/T upstream_transcript_variant
rs1003403054 -- 101,060,227(+) T/C upstream_transcript_variant
rs1004576493 -- 101,060,396(+) C/T upstream_transcript_variant
rs1005838553 -- 101,061,199(+) T/C upstream_transcript_variant
rs1006959092 -- 101,061,936(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR377 Gene

Variant ID Type Subtype PubMed ID
nsv565860 CNV gain 21841781
nsv565859 CNV gain 21841781
nsv509551 CNV insertion 20534489
nsv1040993 CNV gain 25217958
esv3635521 CNV gain 21293372

Additional Variant Information for MIR377 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR377

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR377 Gene

Disorders for MIR377 Gene

Additional Disease Information for MIR377

No disorders were found for MIR377 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR377 Gene

Publications for MIR377 Gene

  1. miR-377 induces senescence in human skin fibroblasts by targeting DNA methyltransferase 1. (PMID: 28277545) Xie HF … Li J (Cell death & disease 2017) 3 58
  2. MicroRNA-377 suppresses initiation and progression of esophageal cancer by inhibiting CD133 and VEGF. (PMID: 28288140) Li B … Cheung ALM (Oncogene 2017) 3 58
  3. Downregulation of miR-377 Promotes Oral Squamous Cell Carcinoma Growth and Migration by Targeting HDAC9. (PMID: 28267394) Rastogi B … Khullar M (Cancer investigation 2017) 3 58
  4. MicroRNA-377 Downregulates Bcl-xL and Increases Apoptosis in Hepatocellular Carcinoma Cells. (PMID: 28081730) Ge H … Wang L (Oncology research 2017) 3 58
  5. MiR-377 inhibits the proliferation of pancreatic cancer by targeting Pim-3. (PMID: 27638830) Chang W … Chen P (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 58

Products for MIR377 Gene

Sources for MIR377 Gene

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