microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR376C Gene

Subcategory (RNA class) for MIR376C Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR376C Gene

  • MicroRNA 376c 2 3 5
  • Hsa-MiR-376c-3p 168 179
  • MicroRNA 368 2 3
  • Hsa-Mir-376c 3
  • MIMAT0000720 53
  • MIMAT0022861 53
  • Hsa-Mir-368 3
  • MI0000776 53
  • MiRNA368 3
  • Mir-376c 3
  • MIRN376C 3
  • MIRN368 3
  • RF00641 174
  • MIR376C 2
  • MIR368 3

External Ids for MIR376C Gene

Previous HGNC Symbols for MIR376C Gene

  • MIRN368
  • MIRN376C

Previous GeneCards Identifiers for MIR376C Gene

  • GC14P100802
  • GC14P100897
  • GC14P101507
  • GC14P101538
  • GC14P101571
  • GC14P101613
  • GC14P101641
  • GC14P101673
  • GC14P101706
  • GC14P101747
  • GC14P101812
  • GC14P101952
  • GC14P102143
  • GC14P101248
  • GC14P101854
  • GC14P103618
  • GC14P103836
  • GC14P102106
  • GC14P102343
  • GC14P102513
  • GC14P102692
  • GC14P102860
  • GC14P103036
  • GC14P103230
  • GC14P103436

Summaries for MIR376C Gene

Entrez Gene Summary for MIR376C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR376C Gene

MIR376C (MicroRNA 376c) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR376C include Ovarian Cancer and Facioscapulohumeral Muscular Dystrophy 1.

Rfam classification for MIR376C Gene

Additional gene information for MIR376C Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR376C Gene

Genomics for MIR376C Gene

GeneHancer (GH) Regulatory Elements for MIR376C Gene

Promoters and enhancers for MIR376C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR376C on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR376C Gene

Genomic Locations for MIR376C Gene
chr14:101,039,683-101,039,762
(GRCh38/hg38)
Size:
80 bases
Orientation:
Plus strand
chr14:101,506,017-101,506,102
(GRCh37/hg19)
Size:
86 bases
Orientation:
Plus strand

Genomic View for MIR376C Gene

Genes around MIR376C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR376C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR376C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR376C Gene

Proteins for MIR376C Gene

Post-translational modifications for MIR376C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR376C Gene

Domains & Families for MIR376C Gene

Gene Families for MIR376C Gene

genes like me logo Genes that share domains with MIR376C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR376C Gene

Function for MIR376C Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR376C Gene

Localization for MIR376C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR376C gene
Compartment Confidence
extracellular 1

Gene Ontology (GO) - Cellular Components for MIR376C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR376C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR376C Gene

Pathways & Interactions for MIR376C Gene

PathCards logo

SuperPathways for MIR376C Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR376C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR376C: view

No data available for Pathways by source and SIGNOR curated interactions for MIR376C Gene

Drugs & Compounds for MIR376C Gene

No Compound Related Data Available

Transcripts for MIR376C Gene

mRNA/cDNA for MIR376C Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(4) RNACentral transcripts :
(5) ENA transcripts :
(1) Rfam transcripts :
(1) LncBase transcripts :
(3) miRBase transcripts :
(1) TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR376C Gene

No ASD Table

Relevant External Links for MIR376C Gene

GeneLoc Exon Structure for
MIR376C
ECgene alternative splicing isoforms for
MIR376C

Expression for MIR376C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR376C Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR376C Gene:

MIR376C
genes like me logo Genes that share expression patterns with MIR376C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR376C Gene

Orthologs for MIR376C Gene

Evolution for MIR376C Gene

ENSEMBL:
Gene Tree for MIR376C (if available)
TreeFam:
Gene Tree for MIR376C (if available)

No data available for Orthologs for MIR376C Gene

Paralogs for MIR376C Gene

No data available for Paralogs for MIR376C Gene

Variants for MIR376C Gene

Sequence variations from dbSNP and Humsavar for MIR376C Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000084197 -- 101,037,952(+) G/A upstream_transcript_variant
rs1000454623 -- 101,038,656(+) G/A/T upstream_transcript_variant
rs1001865358 -- 101,038,056(+) T/A upstream_transcript_variant
rs1003009472 -- 101,039,870(+) T/C downstream_transcript_variant
rs1008717797 -- 101,038,899(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR376C Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Additional Variant Information for MIR376C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR376C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR376C Gene

Disorders for MIR376C Gene

MalaCards: The human disease database

(4) MalaCards diseases for MIR376C Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
ovarian cancer
  • ovarian cancer, somatic
facioscapulohumeral muscular dystrophy 1
  • fmd
dermatomyositis
  • amyopathic dermatomyositis
muscular dystrophy, duchenne type
  • dmd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR376C

genes like me logo Genes that share disorders with MIR376C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR376C Gene

Publications for MIR376C Gene

  1. MiR-376c-3p regulates the proliferation, invasion, migration, cell cycle and apoptosis of human oral squamous cancer cells by suppressing HOXB7. (PMID: 28482289) Wang K … Zhai H (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017) 3 56
  2. miR-376c promotes carcinogenesis and serves as a plasma marker for gastric carcinoma. (PMID: 28486502) Hung PS … Lo SS (PloS one 2017) 3 56
  3. Thrombospondin-2 promotes prostate cancer bone metastasis by the up-regulation of matrix metalloproteinase-2 through down-regulating miR-376c expression. (PMID: 28122633) Chen PC … Huang YL (Journal of hematology & oncology 2017) 3 56
  4. miR-376c inhibits cervical cancer cell proliferation and invasion by targeting BMI1. (PMID: 27345009) Deng Y … Liu Y (International journal of experimental pathology 2016) 3 56
  5. Dysregulation of RUNX2/Activin-A Axis upon miR-376c Downregulation Promotes Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma. (PMID: 27760788) Chang WM … Shiah SG (Cancer research 2016) 3 56

Products for MIR376C Gene

Sources for MIR376C Gene