microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR376B Gene

Subcategory (RNA class) for MIR376B Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR376B Gene

  • MicroRNA 376b 2 3 5
  • Hsa-Mir-376b 2 3
  • MIR376B 2 5
  • Hsa-MiR-376b-3p 173
  • Hsa-Mir-376-P3 178
  • MIMAT0022923 50
  • MIMAT0002172 50
  • MI0002466 50
  • MIRN376B 3
  • Mir-376b 3
  • RF00641 168

External Ids for MIR376B Gene

Previous HGNC Symbols for MIR376B Gene

  • MIRN376B

Previous GeneCards Identifiers for MIR376B Gene

  • GC14P100805
  • GC14P100899
  • GC14P101509
  • GC14P101565
  • GC14P101598
  • GC14P081690
  • GC14P101664
  • GC14P101699
  • GC14P101736
  • GC14P101776
  • GC14P101834
  • GC14P101974
  • GC14P102171
  • GC14P101250
  • GC14P101857
  • GC14P103617
  • GC14P103832
  • GC14P104108
  • GC14P104452
  • GC14P102109
  • GC14P102346
  • GC14P102516
  • GC14P102696
  • GC14P102863
  • GC14P103039
  • GC14P103234
  • GC14P103435

Summaries for MIR376B Gene

Entrez Gene Summary for MIR376B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR376B Gene

MIR376B (MicroRNA 376b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR376B include Ovarian Cancer and Leiomyoma, Uterine.

Rfam classification for MIR376B Gene

Additional gene information for MIR376B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR376B Gene

Genomics for MIR376B Gene

Genomic Locations for MIR376B Gene

Genomic Locations for MIR376B Gene
chr14:101,040,436-101,040,535
(GRCh38/hg38)
Size:
100 bases
Orientation:
Plus strand
chr14:101,506,773-101,506,872
(GRCh37/hg19)
Size:
100 bases
Orientation:
Plus strand

Genomic View for MIR376B Gene

Genes around MIR376B on UCSC Golden Path with GeneCards custom track
MIR376B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR376B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR376B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR376B Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR376B Gene

Proteins for MIR376B Gene

Post-translational modifications for MIR376B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR376B Gene

Domains & Families for MIR376B Gene

Gene Families for MIR376B Gene

genes like me logo Genes that share domains with MIR376B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR376B Gene

Function for MIR376B Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR376B Gene

Localization for MIR376B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR376B gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR376B Gene

Pathways & Interactions for MIR376B Gene

PathCards logo

SuperPathways for MIR376B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR376B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR376B: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR376B Gene

Drugs & Compounds for MIR376B Gene

No Compound Related Data Available

Transcripts for MIR376B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR376B Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075A7C0_9606 precursor_RNA 100 5

HGNC: 32066,

RefSeq: NR_030157,

Ensembl: ENST00000614515 (view in UCSC) ,

miRBase: MI0002466,

ENA: LM609400.1:1..100:precursor_RNA,

URS00003AD231_9606 miRNA 22 4

RefSeq: NR_030157,

miRBase: MIMAT0002172,

TarBase: hsa-miR-376b-3p,

ENA: LM379706.1:1..22:ncRNA, LM609400.1:62..83:ncRNA,

URS000047736C_9606 miRNA 22 3

RefSeq: NR_030157,

miRBase: MIMAT0022923,

ENA: LM383083.1:1..22:ncRNA, LM609400.1:24..45:ncRNA,

URS000064D59F_9606 precursor_RNA 80 1

Rfam: RF00641,

URS0000EFC8FD_9606 precursor_RNA 59 1

MirGeneDB: Hsa-Mir-376-P3,

MIR376B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR376B Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR376B Gene

No ASD Table

Relevant External Links for MIR376B Gene

GeneLoc Exon Structure for
MIR376B

Expression for MIR376B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR376B

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR376B Gene

Orthologs for MIR376B Gene

Evolution for MIR376B Gene

ENSEMBL:
Gene Tree for MIR376B (if available)
TreeFam:
Gene Tree for MIR376B (if available)

No data available for Orthologs for MIR376B Gene

Paralogs for MIR376B Gene

No data available for Paralogs for MIR376B Gene

Variants for MIR376B Gene

Additional dbSNP identifiers (rs#s) for MIR376B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR376B Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Additional Variant Information for MIR376B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR376B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR376B Gene

Disorders for MIR376B Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR376B Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
ovarian cancer
  • ovarian cancer, somatic
leiomyoma, uterine
  • ul
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR376B

genes like me logo Genes that share disorders with MIR376B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR376B Gene

Publications for MIR376B Gene

  1. miR-376b-5p regulates angiogenesis in cerebral ischemia. (PMID: 24789343) Li LJ … Liu YH (Molecular medicine reports 2014) 3
  2. miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1. (PMID: 22248718) Korkmaz G … Gozuacik D (Autophagy 2012) 3
  3. Differential microRNA expression in peripheral blood mononuclear cells from Graves' disease patients. (PMID: 22456620) Liu R … Wang S (The Journal of clinical endocrinology and metabolism 2012) 3
  4. Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs. (PMID: 22282338) Voellenkle C … Martelli F (RNA (New York, N.Y.) 2012) 3
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3

Products for MIR376B Gene

Sources for MIR376B Gene