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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR375 Gene
RNA type for MIR375 Gene
miRNA
Aliases for MIR375 Gene
- MicroRNA 375 (HGNC, NCBI Entrez Gene, Ensembl)
- Hsa-Mir-375 (HGNC, NCBI Entrez Gene)
- Hsa-MiR-375 (LncBase, TarBase)
- MIMAT0037313 (miRBase)
- MIMAT0000728 (miRBase)
- MI0000783 (miRBase)
- MiRNA375 (NCBI Entrez Gene)
- MIRN375 (NCBI Entrez Gene)
- Mir-375 (NCBI Entrez Gene)
- RF00700 (Rfam)
- MIR375 (Ensembl)
External Ids for MIR375 Gene
- HGNC: 31868
- NCBI Entrez Gene: 494324
- Ensembl: ENSG00000198973
- OMIM®: 611173
- miRBase: hsa-mir-375
Previous HGNC Symbols for MIR375 Gene
- MIRN375
Previous GeneCards Identifiers for MIR375 Gene
- GC02M219576
- GC02M219866
Summaries for MIR375 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR375 Gene
MIR375 (MicroRNA 375) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR375 include Lung Cancer Susceptibility 3 and Diabetes Mellitus. Among its related pathways are Mesodermal Commitment Pathway and MicroRNAs in cancer.
Rfam classification for MIR375 Gene
-
microRNA mir-375
Additional gene information for MIR375 Gene
- HGNC (31868)
- NCBI Entrez Gene (494324)
- Ensembl (ENSG00000198973)
- OMIM® (611173)
- Open Targets Platform(ENSG00000198973)
- Alliance of Genome Resources
- Search for MIR375 at DataMed
- Search for MIR375 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR375 Gene
Genomics for MIR375 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR375 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR375 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR375 Gene
Latest Assembly
- chr2:219,001,641-219,001,708
- (GRCh38/hg38)
- Size:
- 68 bases
- Orientation:
- Minus strand
Previous Assembly
- chr2:219,866,367-219,866,430
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 64 bases
- Orientation:
- Minus strand
Genomic View for MIR375 Gene
Genes around MIR375 on UCSC Golden Path with GeneCards custom track
MIR375 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 2q35 by HGNC
- 2q35 by Entrez Gene
- 2q35 by Ensembl
MIR375 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR375 Gene
Proteins for MIR375 Gene
Post-translational modifications for MIR375 Gene
No Post-translational modifications
No data available for DME Specific Peptides for MIR375 Gene
Domains & Families for MIR375 Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR375 Gene
Function for MIR375 Gene
Phenotypes From GWAS Catalog for MIR375 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000993 | RNA polymerase II complex binding | IDA | 25336585 |
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR375 - Starting at $85 >
- * MIR375 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR375 - Starting at $45 >
- * MIR375 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR375 Gene
Localization for MIR375 Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endosome | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | 26646931 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR375 Gene
Pathways & Interactions for MIR375 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Mesodermal Commitment Pathway | ||
| 2 | MicroRNAs in cancer | ||
| 3 | Alzheimers Disease | ||
| 4 | Parkinsons Disease Pathway | ||
Pathways by source for MIR375 Gene
4 BioSystems pathways for MIR375 Gene
1 KEGG pathway for MIR375 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0035195 | gene silencing by miRNA | IEA | -- |
| GO:0051898 | negative regulation of protein kinase B signaling | ISS | -- |
| GO:1903671 | negative regulation of sprouting angiogenesis | IGI | 26235810 |
| GO:2000353 | positive regulation of endothelial cell apoptotic process | IGI | 26235810 |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR375 Gene
Transcripts for MIR375 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR375 Gene
| RNAcentral Transcript ID | RNA Type | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS00000ED600_9606 | miRNA | 22 | 6 |
RefSeq: NR_029867, LncBase: hsa-miR-375, miRBase: MIMAT0000728, MirGeneDB: Hsa-Mir-375_3p, TarBase: hsa-miR-375, ENA: HB859631.1:1..22:misc_RNA, LM379234.1:1..22:ncRNA, LM608701.1:40..61:ncRNA, |
| URS000075BCF9_9606 | pre_miRNA | 64 | 4 |
RefSeq: NR_029867, Ensembl: ENST00000362103 (view in UCSC) , miRBase: MI0000783, |
| URS000075CCDA_9606 | miRNA | 23 | 3 |
RefSeq: NR_029867, miRBase: MIMAT0037313, MirGeneDB: Hsa-Mir-375_5p, |
| URS000020B181_9606 | pre_miRNA | 68 | 1 |
Rfam: RF00700, |
| URS0000EFEDF3_9606 | pre_miRNA | 58 | 1 |
MirGeneDB: Hsa-Mir-375, |
MIR375 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for MIR375 Gene
- 1 NCBI additional mRNA sequence :
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR375 - Starting at $85 >
- * MIR375 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA products for research
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR375 - Starting at $45 >
- * MIR375 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for MIR375 Gene
- GeneLoc Exon Structure for
- MIR375
Expression for MIR375 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR375
Evidence on tissue expression from TISSUES for MIR375 Gene
- Pancreas(2.3)
- Blood(2.1)
No Expression Related Data Available
Primer products for research
-
OriGene qPCR primer pairs for MIR375
Gene Expression Assays for research
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR375 Gene
Orthologs for MIR375 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Cow (Bos Taurus) |
Mammalia | bta-mir-375 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | cfa-mir-375 30 |
|
OneToOne | |
| Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-375 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-375 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Mir375 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | gga-mir-375 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | aca-mir-375 30 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-375-2 30 |
|
OneToMany | |
| dre-mir-375-1 30 |
|
OneToMany |
- Species where no ortholog for MIR375 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for MIR375 Gene
- ENSEMBL:
- Gene Tree for MIR375 (if available)
- TreeFam:
- Gene Tree for MIR375 (if available)
- Alliance of Genome Resources:
- Additional Orthologs for MIR375
Paralogs for MIR375 Gene
No data available for Paralogs for MIR375 Gene
Variants for MIR375 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Additional Variant Information for MIR375 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR375 Gene
Disorders for MIR375 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lung cancer susceptibility 3 |
|
|
| diabetes mellitus |
|
|
| squamous cell carcinoma, head and neck |
|
|
| pancreatic ductal adenocarcinoma |
|
|
| esophageal cancer |
|
Search MIR375 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR375
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR375 Gene
Publications for MIR375 Gene
- MiR-375 is Essential for Human Spinal Motor Neuron Development and May Be Involved in Motor Neuron Degeneration. (PMID: 26507573) Bhinge A … Stanton LW (Stem cells (Dayton, Ohio) 2016) 2 3
- Function of microRNA-375 and microRNA-124a in pancreas and brain. (PMID: 20102393) Baroukh NN … Van Obberghen E (The FEBS journal 2009) 2 3
- A pancreatic islet-specific microRNA regulates insulin secretion. (PMID: 15538371) Poy MN … Stoffel M (Nature 2004) 3 72
- Exosome-mediated delivery of functionally active miRNA-375-3p mimic regulate epithelial mesenchymal transition (EMT) of colon cancer cells. (PMID: 33450254) Rezaei R … Zali MR (Life sciences 2021) 3
- Circ_0086720 knockdown strengthens the radiosensitivity of non-small cell lung cancer via mediating the miR-375/SPIN1 axis. (PMID: 32940043) Jin Y … Li S (Neoplasma 2021) 3
ExternalLinks
Products for MIR375 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR375
- Origene Custom Protein Services for MIR375
- Browse OriGene Inhibitory RNA Products For MIR375
- OriGene qPCR primer pairs for MIR375
- Browse CRISPR knockouts for MIR375
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR375
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR375
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR375
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR375
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR375
Sources for MIR375 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources