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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR375 (MicroRNA 375) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR375 include Diabetes Mellitus and Lung Cancer Susceptibility 3. Among its related pathways are Parkinsons Disease Pathway and Mesodermal Commitment Pathway.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000993 | RNA polymerase II complex binding | IDA | 25336585 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 26646931 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Mesodermal Commitment Pathway | ||
2 | MicroRNAs in cancer | ||
3 | Alzheimers Disease | ||
4 | Parkinsons Disease Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IEA | -- |
GO:0051898 | negative regulation of protein kinase B signaling | ISS | -- |
GO:1903671 | negative regulation of sprouting angiogenesis | IGI | 26235810 |
GO:2000353 | positive regulation of endothelial cell apoptotic process | IGI | 26235810 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00000ED600_9606 | miRNA | 22 | 6 |
RefSeq: NR_029867, LncBase: hsa-miR-375, miRBase: MIMAT0000728, MirGeneDB: Hsa-Mir-375_3p, TarBase: hsa-miR-375, ENA: HB859631.1:1..22:misc_RNA, LM379234.1:1..22:ncRNA, LM608701.1:40..61:ncRNA, |
URS000075BCF9_9606 | precursor_RNA | 64 | 5 |
HGNC: 31868, RefSeq: NR_029867, Ensembl: ENST00000362103 (view in UCSC) , miRBase: MI0000783, |
URS000075CCDA_9606 | miRNA | 23 | 3 |
RefSeq: NR_029867, miRBase: MIMAT0037313, MirGeneDB: Hsa-Mir-375_5p, |
URS000020B181_9606 | precursor_RNA | 68 | 1 |
Rfam: RF00700, |
URS0000EFEDF3_9606 | precursor_RNA | 58 | 1 |
MirGeneDB: Hsa-Mir-375, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Cow (Bos Taurus) |
Mammalia | bta-mir-375 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-375 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-375 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-375 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir375 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | gga-mir-375 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | aca-mir-375 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | dre-mir-375-2 31 |
|
OneToMany | |
dre-mir-375-1 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
diabetes mellitus |
|
|
lung cancer susceptibility 3 |
|
|
pancreatic ductal adenocarcinoma |
|
|
squamous cell carcinoma, head and neck |
|
|
esophageal cancer |
|