microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR375 Gene

Subcategory (RNA class) for MIR375 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR375 Gene

  • MIMAT0000728 50
  • MI0000783 50
  • MiRNA375 3
  • MIRN375 3
  • Mir-375 3
  • RF00700 168

External Ids for MIR375 Gene

Previous HGNC Symbols for MIR375 Gene

  • MIRN375

Previous GeneCards Identifiers for MIR375 Gene

  • GC02M219576
  • GC02M219866

Summaries for MIR375 Gene

Entrez Gene Summary for MIR375 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR375 Gene

MIR375 (MicroRNA 375) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR375 include Diabetes Mellitus and Lung Cancer Susceptibility 3. Among its related pathways are Parkinsons Disease Pathway and Mesodermal Commitment Pathway.

Rfam classification for MIR375 Gene

Additional gene information for MIR375 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR375 Gene

Genomics for MIR375 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR375 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J218997 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 600.7 +1.2 1232 5.7 HNRNPL GATAD2A CTCF ZBTB33 PRDM10 ZNF629 TFE3 SOX13 RCOR2 ZNF7 LOC100129175 MIR375 PNKD FEV CRYBA2 CFAP65
GH02J218829 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.6 +169.2 169194 5.8 KDM1A ZIC2 ZNF600 ESR1 CEBPB RCOR1 ZFHX2 BCOR ZNF768 ZNF513 PRKAG3 WNT6 PLCD4 RNF25 STK36 LOC100129175 MIR375 SLC11A1 RPL23AP31
GH02J219121 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 10.8 -123.5 -123531 7.5 GATAD2A PRDM10 IKZF1 NFKBIZ RCOR2 ZNF7 JUND FOXA1 ZSCAN4 RXRB lnc-IHH-1 SLC23A3 NHEJ1 IHH LOC100129175 MIR375 CRYBA2 FEV LINC00608 RETREG2
GH02J219059 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 10.7 -58.2 -58204 3.3 HNRNPL GATAD2A CTCF ATF7 TFE3 ZIC2 RBFOX2 RXRB REST RAD21 IHH MIR3131 LOC100129175 MIR375 NHEJ1 SLC23A3 CFAP65
GH02J219070 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.8 -70.7 -70697 4 GATAD2A CTCF SOX13 RCOR2 RXRB REST RAD21 IRF2 SP1 TRIM22 MN297770 NHEJ1 SLC23A3 MIR375 LOC100129175 PTPRN ZFAND2B IHH lnc-RETREG2-3 RF00017-3429
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR375 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR375 Gene

Genomic Locations for MIR375 Gene
chr2:219,001,641-219,001,708
(GRCh38/hg38)
Size:
68 bases
Orientation:
Minus strand
chr2:219,866,362-219,866,431
(GRCh37/hg19)
Size:
70 bases
Orientation:
Minus strand

Genomic View for MIR375 Gene

Genes around MIR375 on UCSC Golden Path with GeneCards custom track
MIR375 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR375 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR375 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR375 Gene

Proteins for MIR375 Gene

Post-translational modifications for MIR375 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR375 Gene

Domains & Families for MIR375 Gene

Gene Families for MIR375 Gene

HGNC:
genes like me logo Genes that share domains with MIR375: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR375 Gene

Function for MIR375 Gene

Phenotypes From GWAS Catalog for MIR375 Gene

Gene Ontology (GO) - Molecular Function for MIR375 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II complex binding IDA 25336585
genes like me logo Genes that share ontologies with MIR375: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR375 Gene

Localization for MIR375 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR375 gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endosome 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIR375 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR375: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR375 Gene

Pathways & Interactions for MIR375 Gene

genes like me logo Genes that share pathways with MIR375: view

Pathways by source for MIR375 Gene

Gene Ontology (GO) - Biological Process for MIR375 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
GO:0051898 negative regulation of protein kinase B signaling ISS --
GO:1903671 negative regulation of sprouting angiogenesis IGI 26235810
GO:2000353 positive regulation of endothelial cell apoptotic process IGI 26235810
genes like me logo Genes that share ontologies with MIR375: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR375 Gene

Drugs & Compounds for MIR375 Gene

No Compound Related Data Available

Transcripts for MIR375 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR375 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00000ED600_9606 miRNA 22 6

RefSeq: NR_029867,

LncBase: hsa-miR-375,

miRBase: MIMAT0000728,

MirGeneDB: Hsa-Mir-375_3p,

TarBase: hsa-miR-375,

ENA: HB859631.1:1..22:misc_RNA, LM379234.1:1..22:ncRNA, LM608701.1:40..61:ncRNA,

URS000075BCF9_9606 precursor_RNA 64 5

HGNC: 31868,

RefSeq: NR_029867,

Ensembl: ENST00000362103 (view in UCSC) ,

miRBase: MI0000783,

ENA: LM608701.1:1..64:precursor_RNA,

URS000075CCDA_9606 miRNA 23 3

RefSeq: NR_029867,

miRBase: MIMAT0037313,

MirGeneDB: Hsa-Mir-375_5p,

URS000020B181_9606 precursor_RNA 68 1

Rfam: RF00700,

URS0000EFEDF3_9606 precursor_RNA 58 1

MirGeneDB: Hsa-Mir-375,

MIR375 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR375 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR375 Gene

No ASD Table

Relevant External Links for MIR375 Gene

GeneLoc Exon Structure for
MIR375

Expression for MIR375 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR375

Evidence on tissue expression from TISSUES for MIR375 Gene

  • Pancreas(2.6)
  • Blood(2.4)
  • Liver(2.2)
  • Lymph node(2.2)
  • Intestine(2.1)
  • Urine(2.1)
  • Saliva(2.1)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR375 Gene

Orthologs for MIR375 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR375 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia bta-mir-375 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-375 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-375 31
  • 100 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-375 31
  • 98 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir375 31
  • 93 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-375 31
  • 85 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-375 31
  • 82 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-375-2 31
  • 61 (a)
OneToMany
dre-mir-375-1 31
  • 60 (a)
OneToMany
Species where no ortholog for MIR375 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR375 Gene

ENSEMBL:
Gene Tree for MIR375 (if available)
TreeFam:
Gene Tree for MIR375 (if available)

Paralogs for MIR375 Gene

No data available for Paralogs for MIR375 Gene

Variants for MIR375 Gene

Additional dbSNP identifiers (rs#s) for MIR375 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR375 Gene

Variant ID Type Subtype PubMed ID
nsv584491 CNV loss 21841781
nsv834542 CNV gain 17160897
nsv954839 CNV deletion 24416366

Additional Variant Information for MIR375 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR375

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR375 Gene

Disorders for MIR375 Gene

MalaCards: The human disease database

(16) MalaCards diseases for MIR375 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diabetes mellitus
  • diabetes
lung cancer susceptibility 3
  • lncr3
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
squamous cell carcinoma, head and neck
  • hnscc
esophageal cancer
  • esophageal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR375: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR375 Gene

Publications for MIR375 Gene

  1. MiR-375 is Essential for Human Spinal Motor Neuron Development and May Be Involved in Motor Neuron Degeneration. (PMID: 26507573) Bhinge A … Stanton LW (Stem cells (Dayton, Ohio) 2016) 2 3
  2. Function of microRNA-375 and microRNA-124a in pancreas and brain. (PMID: 20102393) Baroukh NN … Van Obberghen E (The FEBS journal 2009) 2 3
  3. Serum Level of microRNA-375-3p Is Not a Reliable Biomarker of Teratoma. (PMID: 31882475) Belge G … Dieckmann KP (In vivo (Athens, Greece) 2020) 3
  4. MicroRNA-375-3p enhances chemosensitivity to 5-fluorouracil by targeting thymidylate synthase in colorectal cancer. (PMID: 32073706) Xu F … Zhao Q (Cancer science 2020) 3
  5. Overexpression of miR-375 Protects Cardiomyocyte Injury following Hypoxic-Reoxygenation Injury. (PMID: 31976033) Ali Sheikh MS (Oxidative medicine and cellular longevity 2020) 3

Products for MIR375 Gene

Sources for MIR375 Gene