microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR375 Gene

RNA type for MIR375 Gene

miRNA

Aliases for MIR375 Gene

External Ids for MIR375 Gene

Previous HGNC Symbols for MIR375 Gene

  • MIRN375

Previous GeneCards Identifiers for MIR375 Gene

  • GC02M219576
  • GC02M219866

Summaries for MIR375 Gene

Entrez Gene Summary for MIR375 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR375 Gene

MIR375 (MicroRNA 375) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR375 include Lung Cancer Susceptibility 3 and Diabetes Mellitus. Among its related pathways are Mesodermal Commitment Pathway and MicroRNAs in cancer.

Rfam classification for MIR375 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR375 Gene

Genomics for MIR375 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR375 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J218997 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 250.7 +1.2 1232 5.7 ZNF600 POLR2A ZIC2 CHD4 YY1 REST KLF11 ETS1 ZNF341 HOMEZ HSALNG0022324 LOC100129175 MIR375 PNKD FEV CRYBA2 CFAP65
GH02J218829 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.6 +169.4 169391 5.4 ZNF600 ZIC2 CEBPB ZNF513 NBN JUND GATA3 ZNF217 MAFF ZNF768 PRKAG3 HSALNG0022300 WNT6 PLCD4 RNF25 STK36 LOC100129175 MIR375 SLC11A1 RPL23AP31
GH02J219121 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 10.8 -123.5 -123531 7.5 NCOR1 IKZF1 KLF9 CEBPA ATF3 JUND NFIC HES1 BHLHE40 HOMEZ lnc-IHH-1 SLC23A3 NHEJ1 IHH LOC100129175 MIR375 CRYBA2 FEV LINC00608 RETREG2
GH02J219058 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 10.7 -58.1 -58116 3.4 EZH2 ZNF654 ZNF600 ZIC2 CTCF REST TARDBP SIN3A THAP11 FOXA2 IHH MIR3131 LOC100129175 MIR375 NHEJ1 SLC23A3 CFAP65
GH02J219070 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.8 -70.7 -70681 4 CEBPA REST KLF11 TRIM22 HOMEZ CTCF KMT2B FOXA2 KDM6A SMAD4 HSALNG0022332 MN297770 NHEJ1 SLC23A3 LOC100129175 MIR375 PTPRN ZFAND2B IHH lnc-RETREG2-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR375 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR375 Gene

Latest Assembly
chr2:219,001,641-219,001,708
(GRCh38/hg38)
Size:
68 bases
Orientation:
Minus strand

Previous Assembly
chr2:219,866,367-219,866,430
(GRCh37/hg19 by Entrez Gene)
Size:
64 bases
Orientation:
Minus strand

chr2:219,866,362-219,866,431
(GRCh37/hg19 by Ensembl)
Size:
70 bases
Orientation:
Minus strand

Genomic View for MIR375 Gene

Genes around MIR375 on UCSC Golden Path with GeneCards custom track
MIR375 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR375 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR375 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR375 Gene

Proteins for MIR375 Gene

Post-translational modifications for MIR375 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR375 Gene

Domains & Families for MIR375 Gene

Gene Families for MIR375 Gene

HGNC:
genes like me logo Genes that share domains with MIR375: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR375 Gene

Function for MIR375 Gene

Phenotypes From GWAS Catalog for MIR375 Gene

Gene Ontology (GO) - Molecular Function for MIR375 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II complex binding IDA 25336585
genes like me logo Genes that share ontologies with MIR375: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR375 Gene

Localization for MIR375 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR375 gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endosome 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIR375 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR375: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR375 Gene

Pathways & Interactions for MIR375 Gene

genes like me logo Genes that share pathways with MIR375: view

Pathways by source for MIR375 Gene

Gene Ontology (GO) - Biological Process for MIR375 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
GO:0051898 negative regulation of protein kinase B signaling ISS --
GO:1903671 negative regulation of sprouting angiogenesis IGI 26235810
GO:2000353 positive regulation of endothelial cell apoptotic process IGI 26235810
genes like me logo Genes that share ontologies with MIR375: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR375 Gene

Drugs & Compounds for MIR375 Gene

No Compound Related Data Available

Transcripts for MIR375 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR375 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00000ED600_9606 miRNA 22 6

RefSeq: NR_029867,

LncBase: hsa-miR-375,

miRBase: MIMAT0000728,

MirGeneDB: Hsa-Mir-375_3p,

TarBase: hsa-miR-375,

ENA: HB859631.1:1..22:misc_RNA, LM379234.1:1..22:ncRNA, LM608701.1:40..61:ncRNA,

URS000075BCF9_9606 pre_miRNA 64 4

RefSeq: NR_029867,

Ensembl: ENST00000362103 (view in UCSC) ,

miRBase: MI0000783,

ENA: LM608701.1:1..64:precursor_RNA,

URS000075CCDA_9606 miRNA 23 3

RefSeq: NR_029867,

miRBase: MIMAT0037313,

MirGeneDB: Hsa-Mir-375_5p,

URS000020B181_9606 pre_miRNA 68 1

Rfam: RF00700,

URS0000EFEDF3_9606 pre_miRNA 58 1

MirGeneDB: Hsa-Mir-375,

MIR375 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR375 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR375 Gene

No ASD Table

Relevant External Links for MIR375 Gene

GeneLoc Exon Structure for
MIR375

Expression for MIR375 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR375

Evidence on tissue expression from TISSUES for MIR375 Gene

  • Pancreas(2.3)
  • Blood(2.1)
No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR375 Gene

Orthologs for MIR375 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR375 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia bta-mir-375 30
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-375 30
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-375 30
  • 100 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-375 30
  • 98 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir375 30
  • 93 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-375 30
  • 85 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-375 30
  • 82 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-375-2 30
  • 61 (a)
OneToMany
dre-mir-375-1 30
  • 60 (a)
OneToMany
Species where no ortholog for MIR375 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR375 Gene

ENSEMBL:
Gene Tree for MIR375 (if available)
TreeFam:
Gene Tree for MIR375 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR375

Paralogs for MIR375 Gene

No data available for Paralogs for MIR375 Gene

Variants for MIR375 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR375 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR375 Gene

Variant ID Type Subtype PubMed ID
nsv584491 CNV loss 21841781
nsv834542 CNV gain 17160897
nsv954839 CNV deletion 24416366

Additional Variant Information for MIR375 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR375
Leiden Open Variation Database (LOVD)
MIR375

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR375 Gene

Disorders for MIR375 Gene

MalaCards: The human disease database

(14) MalaCards diseases for MIR375 Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
lung cancer susceptibility 3
  • lncr3
diabetes mellitus
  • diabetes
squamous cell carcinoma, head and neck
  • hnscc
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
esophageal cancer
  • esophageal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR375

genes like me logo Genes that share disorders with MIR375: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR375 Gene

Publications for MIR375 Gene

  1. MiR-375 is Essential for Human Spinal Motor Neuron Development and May Be Involved in Motor Neuron Degeneration. (PMID: 26507573) Bhinge A … Stanton LW (Stem cells (Dayton, Ohio) 2016) 2 3
  2. Function of microRNA-375 and microRNA-124a in pancreas and brain. (PMID: 20102393) Baroukh NN … Van Obberghen E (The FEBS journal 2009) 2 3
  3. A pancreatic islet-specific microRNA regulates insulin secretion. (PMID: 15538371) Poy MN … Stoffel M (Nature 2004) 3 72
  4. Exosome-mediated delivery of functionally active miRNA-375-3p mimic regulate epithelial mesenchymal transition (EMT) of colon cancer cells. (PMID: 33450254) Rezaei R … Zali MR (Life sciences 2021) 3
  5. Circ_0086720 knockdown strengthens the radiosensitivity of non-small cell lung cancer via mediating the miR-375/SPIN1 axis. (PMID: 32940043) Jin Y … Li S (Neoplasma 2021) 3

Products for MIR375 Gene

Sources for MIR375 Gene