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Aliases for MIR374B Gene

Subcategory (RNA class) for MIR374B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR374B Gene

  • MicroRNA 374b 2 3 5
  • Hsa-Mir-374b 3
  • Mir-374b 3
  • MIRN374B 3

External Ids for MIR374B Gene

Previous HGNC Symbols for MIR374B Gene

  • MIRN374B

Previous GeneCards Identifiers for MIR374B Gene

  • GC0XM073359
  • GC0XM073439
  • GC0XM073440
  • GC0XM073443
  • GC0XM073446
  • GC0XM074219
  • GC0XM074221
  • GC0XM074222
  • GC0XM074223
  • GC0XM074224
  • GC0XM074225
  • GC0XM074226

Summaries for MIR374B Gene

Entrez Gene Summary for MIR374B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR374B Gene

MIR374B (MicroRNA 374b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNAs involved in DNA damage response.

Additional gene information for MIR374B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR374B Gene

Genomics for MIR374B Gene

GeneHancer (GH) Regulatory Elements for MIR374B Gene

Promoters and enhancers for MIR374B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI074240 Enhancer 1 Ensembl ENCODE 13.2 -23.8 -23808 3 ELF3 FOXA2 THRB RARA CREM MIXL1 RXRA PPARG NFIL3 ETV4 GC0XP074243 RN7SL648P MIR374B MIR421 FTX ZCCHC13 MIR374A MIR545 JPX GC0XP074233
GH0XI074248 Enhancer 1 Ensembl ENCODE 13.2 -32.0 -31984 5 HDAC1 ELF3 FOXA2 FEZF1 ZBTB40 TCF12 ZNF121 ZSCAN5C FOS ZEB2 GC0XP074249 MIR374B MIR421 MIR374A MIR545 FTX JPX ENSG00000278421
GH0XI074246 Enhancer 0.6 ENCODE 13.2 -28.6 -28600 1.2 JUN CEBPB CEBPG EP300 FOSL1 JUND ATF4 FOS FOSL2 MIR374B MIR421 GC0XP074243 GC0XP074249 FTX
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR374B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR374B Gene

Genomic Locations for MIR374B Gene
chrX:74,218,547-74,218,618
(GRCh38/hg38)
Size:
72 bases
Orientation:
Minus strand
chrX:73,438,382-73,438,453
(GRCh37/hg19)

Genomic View for MIR374B Gene

Genes around MIR374B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR374B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR374B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR374B Gene

Proteins for MIR374B Gene

Post-translational modifications for MIR374B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR374B Gene

Domains & Families for MIR374B Gene

Gene Families for MIR374B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR374B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR374B Gene

Function for MIR374B Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR374B Gene

Localization for MIR374B Gene

Gene Ontology (GO) - Cellular Components for MIR374B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR374B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR374B Gene

Pathways & Interactions for MIR374B Gene

genes like me logo Genes that share pathways with MIR374B: view

Pathways by source for MIR374B Gene

1 BioSystems pathway for MIR374B Gene

Interacting Proteins for MIR374B Gene

Gene Ontology (GO) - Biological Process for MIR374B Gene

None

No data available for SIGNOR curated interactions for MIR374B Gene

Drugs & Compounds for MIR374B Gene

No Compound Related Data Available

Transcripts for MIR374B Gene

mRNA/cDNA for MIR374B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR374B Gene

No ASD Table

Relevant External Links for MIR374B Gene

GeneLoc Exon Structure for
MIR374B
ECgene alternative splicing isoforms for
MIR374B

Expression for MIR374B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR374B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR374B Gene:

MIR374B
genes like me logo Genes that share expression patterns with MIR374B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR374B Gene

Orthologs for MIR374B Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR374B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-374b 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-374b 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-374b 34
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir374 34
  • 71 (a)
OneToMany
Species where no ortholog for MIR374B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR374B Gene

ENSEMBL:
Gene Tree for MIR374B (if available)
TreeFam:
Gene Tree for MIR374B (if available)

Paralogs for MIR374B Gene

No data available for Paralogs for MIR374B Gene

Variants for MIR374B Gene

Sequence variations from dbSNP and Humsavar for MIR374B Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000002777 -- 74,219,524(-) C/T upstream_transcript_variant
rs1000033517 -- 74,218,756(-) A/G upstream_transcript_variant
rs1004138518 -- 74,218,503(-) G/A downstream_transcript_variant
rs1008055857 -- 74,219,346(-) G/T upstream_transcript_variant
rs1013069137 -- 74,218,345(-) T/C downstream_transcript_variant

Additional Variant Information for MIR374B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR374B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR374B Gene

Disorders for MIR374B Gene

Additional Disease Information for MIR374B

No disorders were found for MIR374B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR374B Gene

Publications for MIR374B Gene

  1. MicroRNA-374b reduces the proliferation and invasion of colon cancer cells by regulation of LRH-1/Wnt signaling. (PMID: 29128635) Qu R … Guo D (Gene 2018) 3 58
  2. p53/microRNA-374b/AKT1 regulates colorectal cancer cell apoptosis in response to DNA damage. (PMID: 28339062) Gong H … Pan Y (International journal of oncology 2017) 3 58
  3. Serum miRNAs miR-206, 143-3p and 374b-5p as potential biomarkers for amyotrophic lateral sclerosis (ALS). (PMID: 28454844) Waller R … Kirby J (Neurobiology of aging 2017) 3 58
  4. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  5. The potential value of miR-1 and miR-374b as biomarkers for colorectal cancer. (PMID: 26045793) Wu X … Xu Y (International journal of clinical and experimental pathology 2015) 3 58

Products for MIR374B Gene

Sources for MIR374B Gene

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