Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR374A Gene

Subcategory (RNA class) for MIR374A Gene


Quality Score for this RNA gene is


Aliases for MIR374A Gene

  • MicroRNA 374a 2 3 5
  • MicroRNA 374 2 3
  • Hsa-Mir-374a 3
  • Hsa-Mir-374 3
  • Mir-374a 3
  • MIRN374A 3
  • MIRN374 3

External Ids for MIR374A Gene

Previous HGNC Symbols for MIR374A Gene

  • MIRN374
  • MIRN374A

Previous GeneCards Identifiers for MIR374A Gene

  • GC0XM073427
  • GC0XM073507
  • GC0XM074288
  • GC0XM074290
  • GC0XM074291
  • GC0XM074292
  • GC0XM074293
  • GC0XM074294
  • GC0XM074295

Summaries for MIR374A Gene

Entrez Gene Summary for MIR374A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR374A Gene

MIR374A (MicroRNA 374a) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR374A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR374A Gene

Genomics for MIR374A Gene

GeneHancer (GH) Regulatory Elements for MIR374A Gene

Promoters and enhancers for MIR374A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI074286 Enhancer 0.5 ENCODE 550.8 +0.4 405 1.6 CEBPA USF2 FOSL2 FOS MAFK SETDB1 GC0XM074289 GC0XM074297 GC0XM074298 MIR374A MIR545 RAB11FIP1P1 ENSG00000275625 FTX
GH0XI074285 Enhancer 0.2 ENCODE 550.8 +1.4 1396 0.2 GC0XM074289 GC0XM074297 GC0XM074298 MIR374A MIR545 ENSG00000275625 FTX
GH0XI074248 Enhancer 1 Ensembl ENCODE 12.9 +36.8 36755 5 HDAC1 ELF3 FOXA2 FEZF1 ZBTB40 TCF12 ZNF121 ZSCAN5C FOS ZEB2 GC0XP074249 MIR374B MIR421 MIR374A MIR545 FTX JPX ENSG00000278421
GH0XI074240 Enhancer 1 Ensembl ENCODE 12.1 +44.9 44931 3 ELF3 FOXA2 THRB RARA CREM MIXL1 RXRA PPARG NFIL3 ETV4 GC0XP074243 RN7SL648P MIR374B MIR421 FTX ZCCHC13 MIR374A MIR545 JPX GC0XP074233
GH0XI074550 Enhancer 0.9 ENCODE 11.7 -263.1 -263104 0.2 ZNF2 GTF3C2 ZNF121 ZNF213 ZNF143 ATF7 KLF13 DEK RXRA REST FTX MIR545 MIR374A PIR45746 PIR50185
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR374A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR374A Gene

Genomic Locations for MIR374A Gene
72 bases
Minus strand

Genomic View for MIR374A Gene

Genes around MIR374A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR374A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR374A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR374A Gene

Proteins for MIR374A Gene

Post-translational modifications for MIR374A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR374A Gene

Domains & Families for MIR374A Gene

Gene Families for MIR374A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR374A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR374A Gene

Function for MIR374A Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR374A Gene

Localization for MIR374A Gene

Gene Ontology (GO) - Cellular Components for MIR374A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR374A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR374A Gene

Pathways & Interactions for MIR374A Gene

SuperPathways for MIR374A Gene

No Data Available

Interacting Proteins for MIR374A Gene

Gene Ontology (GO) - Biological Process for MIR374A Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR374A Gene

Drugs & Compounds for MIR374A Gene

No Compound Related Data Available

Transcripts for MIR374A Gene

mRNA/cDNA for MIR374A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR374A Gene

No ASD Table

Relevant External Links for MIR374A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR374A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR374A Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR374A Gene

Orthologs for MIR374A Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR374A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-374a 34
  • 100 (a)
(Bos Taurus)
Mammalia bta-mir-374a 34
  • 97 (a)
(Canis familiaris)
Mammalia cfa-mir-374a 34
  • 94 (a)
(Mus musculus)
Mammalia Mir374 34
  • 58 (a)
Species where no ortholog for MIR374A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR374A Gene

Gene Tree for MIR374A (if available)
Gene Tree for MIR374A (if available)

Paralogs for MIR374A Gene

No data available for Paralogs for MIR374A Gene

Variants for MIR374A Gene

Sequence variations from dbSNP and Humsavar for MIR374A Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1001568529 -- 74,286,852(-) T/C downstream_transcript_variant
rs1003229089 -- 74,288,749(-) T/C upstream_transcript_variant
rs1007372455 -- 74,287,096(-) A/G downstream_transcript_variant
rs1010622740 -- 74,288,032(-) G/A upstream_transcript_variant
rs1011073940 -- 74,288,764(-) G/T upstream_transcript_variant

Additional Variant Information for MIR374A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR374A Gene

Disorders for MIR374A Gene

Additional Disease Information for MIR374A

No disorders were found for MIR374A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR374A Gene

Publications for MIR374A Gene

  1. Survival Improvement in Human Retinal Pigment Epithelial Cells via Fas Receptor Targeting by miR-374a. (PMID: 28543858) Tasharrofi N … Dorkoosh FA (Journal of cellular biochemistry 2017) 3 58
  2. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  3. Long noncoding RNA FTX inhibits hepatocellular carcinoma proliferation and metastasis by binding MCM2 and miR-374a. (PMID: 27065331) Liu F … Sun SH (Oncogene 2016) 3 58
  4. MicroRNA miR-374, a potential radiosensitizer for carbon ion beam radiotherapy. (PMID: 27665739) Baek SJ … Ogawa K (Oncology reports 2016) 3 58
  5. MiR-374a suppresses lung adenocarcinoma cell proliferation and invasion by targeting TGFA gene expression. (PMID: 27207663) Wu H … Cai Q (Carcinogenesis 2016) 3 58

Products for MIR374A Gene

Sources for MIR374A Gene

Loading form....