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Aliases for MIR373 Gene

Subcategory (RNA class) for MIR373 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR373 Gene

  • MicroRNA 373 2 3 5
  • Hsa-Mir-373 3
  • MiRNA373 3
  • Mir-373 3
  • MIRN373 3

External Ids for MIR373 Gene

ORGUL Members for MIR373 Gene

Previous HGNC Symbols for MIR373 Gene

  • MIRN373

Previous GeneCards Identifiers for MIR373 Gene

  • GC19P058993
  • GC19P059032
  • GC19P054294
  • GC19P054306
  • GC19P054331
  • GC19P054353
  • GC19P054430
  • GC19P054508
  • GC19P053790
  • GC19P053811
  • GC19P053842
  • GC19P053865
  • GC19P053896
  • GC19P053900
  • GC19P053904

Summaries for MIR373 Gene

Entrez Gene Summary for MIR373 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR373 Gene

MIR373 (MicroRNA 373) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Mesodermal Commitment Pathway and miRNAs involved in DNA damage response.

Additional gene information for MIR373 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR373 Gene

Genomics for MIR373 Gene

GeneHancer (GH) Regulatory Elements for MIR373 Gene

Promoters and enhancers for MIR373 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I053787 Enhancer 0.6 FANTOM5 550.8 -0.8 -761 0 NRF1 ZBTB11 ZBTB40 GTF2A2 DIDO1 GABPB1 TRIM24 CREM MGA ENSG00000269564 ENSG00000269877 GC19P053928 GC19P053932 GC19P053940 GC19P053953 GC19P053959 GC19P053967 MIR371A MIR371B
GH19I053790 Enhancer 0.4 ENCODE 550.8 +1.7 1677 0.2 CTCF ZBTB33 ENSG00000269564 GC19P053928 GC19P053940 GC19P053967 GC19P053980 MIR373 MIR516A2 MIR1283-2 MIR516A1 RNU6-1041P
GH19I053788 Enhancer 0.2 FANTOM5 550.8 -0.1 -55 0.2 ENSG00000269564 ENSG00000269877 GC19P053928 GC19P053932 GC19P053940 GC19P053953 GC19P053959 GC19P053967 MIR371A MIR371B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR373 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR373 Gene

Genomic Locations for MIR373 Gene
chr19:53,788,705-53,788,773
(GRCh38/hg38)
Size:
69 bases
Orientation:
Plus strand
chr19:54,291,959-54,292,027
(GRCh37/hg19)

Genomic View for MIR373 Gene

Genes around MIR373 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR373 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR373 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR373 Gene

Proteins for MIR373 Gene

Post-translational modifications for MIR373 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR373 Gene

Domains & Families for MIR373 Gene

Gene Families for MIR373 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR373: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR373 Gene

Function for MIR373 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR373 Gene

Localization for MIR373 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR373 Gene

Pathways & Interactions for MIR373 Gene

genes like me logo Genes that share pathways with MIR373: view

Pathways by source for MIR373 Gene

Interacting Proteins for MIR373 Gene

Gene Ontology (GO) - Biological Process for MIR373 Gene

None

No data available for SIGNOR curated interactions for MIR373 Gene

Drugs & Compounds for MIR373 Gene

No Compound Related Data Available

Transcripts for MIR373 Gene

mRNA/cDNA for MIR373 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR373 Gene

No ASD Table

Relevant External Links for MIR373 Gene

GeneLoc Exon Structure for
MIR373
ECgene alternative splicing isoforms for
MIR373

Expression for MIR373 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR373 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR373 Gene:

MIR373
genes like me logo Genes that share expression patterns with MIR373: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR373 Gene

Orthologs for MIR373 Gene

Evolution for MIR373 Gene

ENSEMBL:
Gene Tree for MIR373 (if available)
TreeFam:
Gene Tree for MIR373 (if available)

No data available for Orthologs for MIR373 Gene

Paralogs for MIR373 Gene

No data available for Paralogs for MIR373 Gene

Variants for MIR373 Gene

Sequence variations from dbSNP and Humsavar for MIR373 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1001035964 -- 53,789,111(+) G/A/C downstream_transcript_variant
rs1001812818 -- 53,788,443(+) C/A/T upstream_transcript_variant
rs1001886411 -- 53,788,603(+) A/G upstream_transcript_variant
rs1002753504 -- 53,786,947(+) A/G/T upstream_transcript_variant
rs1003751295 -- 53,786,888(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR373 Gene

Variant ID Type Subtype PubMed ID
nsv580108 CNV gain 21841781
nsv458781 CNV gain 19166990
nsv1064558 CNV gain 25217958
nsv1058969 CNV gain 25217958
esv2718812 CNV deletion 23290073

Additional Variant Information for MIR373 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR373

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR373 Gene

Disorders for MIR373 Gene

Additional Disease Information for MIR373

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR373 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR373 Gene

Publications for MIR373 Gene

  1. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J … Wu X (Carcinogenesis 2010) 3 44 58
  2. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J … Wu X (Molecular carcinogenesis 2010) 3 44 58
  3. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y … Wu X (Cancer prevention research (Philadelphia, Pa.) 2008) 3 44 58
  4. miR-373-3p Targets DKK1 to Promote EMT-Induced Metastasis via the Wnt/β-Catenin Pathway in Tongue Squamous Cell Carcinoma. (PMID: 28337453) Weng J … Hou J (BioMed research international 2017) 3 58
  5. Isoproterenol regulates CD44 expression in gastric cancer cells through STAT3/MicroRNA373 cascade. (PMID: 27512943) Wei B … Fu X (Biomaterials 2016) 3 58

Products for MIR373 Gene

Sources for MIR373 Gene

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