microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR373 Gene

Subcategory (RNA class) for MIR373 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR373 Gene

  • MicroRNA 373 2 3 5
  • Hsa-MiR-373-3p 163 173
  • Hsa-MiR-373-5p 163 173
  • Hsa-Mir-373 2 3
  • MIR373 2 5
  • Hsa-Mir-430-P7 178
  • MIMAT0000725 50
  • MIMAT0000726 50
  • MI0000781 50
  • MiRNA373 3
  • MIRN373 3
  • Mir-373 3
  • RF00665 168

External Ids for MIR373 Gene

Previous HGNC Symbols for MIR373 Gene

  • MIRN373

Previous GeneCards Identifiers for MIR373 Gene

  • GC19P058993
  • GC19P059032
  • GC19P054294
  • GC19P054306
  • GC19P054331
  • GC19P054353
  • GC19P054430
  • GC19P054508
  • GC19P053790
  • GC19P053811
  • GC19P053995
  • GC19P054026
  • GC19P054046
  • GC19P054121
  • GC19P053842
  • GC19P053865
  • GC19P053896
  • GC19P053900
  • GC19P053904
  • GC19P053914
  • GC19P053940
  • GC19P053966

Summaries for MIR373 Gene

Entrez Gene Summary for MIR373 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR373 Gene

MIR373 (MicroRNA 373) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR373 include Klatskin's Tumor and Cholangiocarcinoma. Among its related pathways are DNA Damage Response and Mesodermal Commitment Pathway.

Rfam classification for MIR373 Gene

Additional gene information for MIR373 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR373 Gene

Genomics for MIR373 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR373 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J053787 Promoter/Enhancer 1 FANTOM5 Ensembl 600.7 -0.7 -697 2 NRF1 MGA CBX3 ZBTB11 GTF2A2 TBP CREM DIDO1 TAF7 ZBTB40 ENSG00000269564 ENSG00000269877 MIR371A MIR371B MIR372 MIR373 RNU6-1041P MIR1283-2 MIR516A2 MIR516A1
GH19J053790 Enhancer 0.3 ENCODE 600.7 +1.7 1684 0.2 ZBTB33 CTCF ENSG00000269564 MIR373 MIR516A2 MIR1283-2 MIR516A1 RNU6-1041P MIR519A1 MIR527 MIR521-1 RNU6-751P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR373 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR373 Gene

Genomic Locations for MIR373 Gene
chr19:53,788,698-53,788,780
(GRCh38/hg38)
Size:
83 bases
Orientation:
Plus strand
chr19:54,291,959-54,292,027
(GRCh37/hg19)
Size:
69 bases
Orientation:
Plus strand

Genomic View for MIR373 Gene

Genes around MIR373 on UCSC Golden Path with GeneCards custom track
MIR373 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR373 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR373 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR373 Gene

Proteins for MIR373 Gene

Post-translational modifications for MIR373 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR373 Gene

Domains & Families for MIR373 Gene

Gene Families for MIR373 Gene

genes like me logo Genes that share domains with MIR373: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR373 Gene

Function for MIR373 Gene

Gene Ontology (GO) - Molecular Function for MIR373 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 19141645
genes like me logo Genes that share ontologies with MIR373: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR373 Gene

Localization for MIR373 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR373 gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR373 Gene

Pathways & Interactions for MIR373 Gene

genes like me logo Genes that share pathways with MIR373: view

Pathways by source for MIR373 Gene

Gene Ontology (GO) - Biological Process for MIR373 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 19141645
GO:1904046 negative regulation of vascular endothelial growth factor production HMP 18320040
genes like me logo Genes that share ontologies with MIR373: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR373 Gene

Drugs & Compounds for MIR373 Gene

No Compound Related Data Available

Transcripts for MIR373 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR373 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000508C13_9606 miRNA 23 6

RefSeq: NR_029866,

LncBase: hsa-miR-373-3p,

miRBase: MIMAT0000726,

MirGeneDB: Hsa-Mir-430-P7_3p,

TarBase: hsa-miR-373-3p,

ENA: LM379232.1:1..23:ncRNA, LM608699.1:44..66:ncRNA,

URS000075AC39_9606 miRNA 22 6

RefSeq: NR_029866,

LncBase: hsa-miR-373-5p,

miRBase: MIMAT0000725,

MirGeneDB: Hsa-Mir-430-P7_5p,

TarBase: hsa-miR-373-5p,

ENA: LM608699.1:6..27:ncRNA,

URS000075BF4B_9606 precursor_RNA 69 5

HGNC: 31787,

RefSeq: NR_029866,

Ensembl: ENST00000362273 (view in UCSC) ,

miRBase: MI0000781,

ENA: LM608699.1:1..69:precursor_RNA,

URS000071A002_9606 precursor_RNA 83 1

Rfam: RF00665,

URS0000EFD37F_9606 precursor_RNA 62 1

MirGeneDB: Hsa-Mir-430-P7,

MIR373 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR373 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR373 Gene

No ASD Table

Relevant External Links for MIR373 Gene

GeneLoc Exon Structure for
MIR373

Expression for MIR373 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR373 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR373

genes like me logo Genes that share expression patterns with MIR373: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR373 Gene

Orthologs for MIR373 Gene

Evolution for MIR373 Gene

ENSEMBL:
Gene Tree for MIR373 (if available)
TreeFam:
Gene Tree for MIR373 (if available)

No data available for Orthologs for MIR373 Gene

Paralogs for MIR373 Gene

No data available for Paralogs for MIR373 Gene

Variants for MIR373 Gene

Additional dbSNP identifiers (rs#s) for MIR373 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR373 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
nsv1058969 CNV gain 25217958
nsv1064558 CNV gain 25217958
nsv458781 CNV gain 19166990
nsv580108 CNV gain 21841781

Additional Variant Information for MIR373 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR373

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR373 Gene

Disorders for MIR373 Gene

MalaCards: The human disease database

(38) MalaCards diseases for MIR373 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
klatskin's tumor
  • hilar cholangiocarcinoma
cholangiocarcinoma
  • cca
testicular germ cell tumor
  • tgct
esophageal cancer
  • esophageal cancer, somatic
breast cancer
  • breast lobular carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR373

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MIR373: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR373 Gene

Publications for MIR373 Gene

  1. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J … Wu X (Molecular carcinogenesis 2010) 3 41
  2. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J … Wu X (Carcinogenesis 2010) 3 41
  3. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y … Wu X (Cancer prevention research (Philadelphia, Pa.) 2008) 3 41
  4. MicroRNA-373 promotes the development of esophageal squamous cell carcinoma by targeting LATS2 and OXR1. (PMID: 30852977) Wang L … Wang L (The International journal of biological markers 2019) 3
  5. MicroRNA‑373 exerts anti‑tumor functions in human liver cancer by targeting Rab22a. (PMID: 31485646) Ye Y … Xia W (Molecular medicine reports 2019) 3

Products for MIR373 Gene

Sources for MIR373 Gene