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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR372 (MicroRNA 372) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR372 include Testicular Germ Cell Tumor and Lung Cancer. Among its related pathways are Mesodermal Commitment Pathway and miRNAs involved in DNA damage response.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH19J053787 | Promoter/Enhancer | 1 | FANTOM5 Ensembl | 600.7 | +0.1 | 118 | 2 | NRF1 MGA CBX3 ZBTB11 GTF2A2 TBP CREM DIDO1 TAF7 ZBTB40 | ENSG00000269564 ENSG00000269877 MIR371A MIR371B MIR372 MIR373 RNU6-1041P MIR1283-2 MIR516A2 MIR516A1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA, HDA | 20190813 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Mesodermal Commitment Pathway | ||
2 | miRNAs involved in DNA damage response |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008284 | positive regulation of cell proliferation | IDA | 20190813 |
GO:0035195 | gene silencing by miRNA | IDA, IEA, HDA | -- |
GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle | IDA | 20190813 |
GO:1904046 | negative regulation of vascular endothelial growth factor production | HMP | 18320040 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS0000759ECA_9606 | miRNA | 23 | 5 |
RefSeq: NR_029865, LncBase: hsa-miR-372-3p, miRBase: MIMAT0000724, MirGeneDB: Hsa-Mir-430-P6_3p, TarBase: hsa-miR-372-3p, |
URS000075E430_9606 | precursor_RNA | 67 | 4 |
HGNC: 31786, RefSeq: NR_029865, Ensembl: ENST00000362225 (view in UCSC) , miRBase: MI0000780, |
URS000075B4E5_9606 | miRNA | 23 | 3 |
RefSeq: NR_029865, miRBase: MIMAT0026484, MirGeneDB: Hsa-Mir-430-P6_5p, |
URS0000693DE8_9606 | precursor_RNA | 80 | 1 |
Rfam: RF00665, |
URS0000EFE703_9606 | precursor_RNA | 60 | 1 |
MirGeneDB: Hsa-Mir-430-P6, |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-372 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir291a 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | gga-mir-219b 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2718812 | CNV | deletion | 23290073 |
nsv1058969 | CNV | gain | 25217958 |
nsv1064558 | CNV | gain | 25217958 |
nsv458781 | CNV | gain | 19166990 |
nsv580108 | CNV | gain | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
testicular germ cell tumor |
|
|
lung cancer |
|
|
oral squamous cell carcinoma |
|
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leukemia, acute myeloid |
|
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colorectal cancer |
|