microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR372 Gene

RNA type for MIR372 Gene

miRNA

Aliases for MIR372 Gene

External Ids for MIR372 Gene

Previous HGNC Symbols for MIR372 Gene

  • MIRN372

Previous GeneCards Identifiers for MIR372 Gene

  • GC19P058992
  • GC19P059031
  • GC19P054291
  • GC19P053789
  • GC19P053810
  • GC19P053994
  • GC19P054025
  • GC19P054045
  • GC19P054120
  • GC19P053841
  • GC19P053862
  • GC19P053894
  • GC19P053895
  • GC19P053902
  • GC19P053913
  • GC19P053939
  • GC19P053965
  • GC19P054631
  • GC19P055576

Summaries for MIR372 Gene

Entrez Gene Summary for MIR372 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR372 Gene

MIR372 (MicroRNA 372) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR372 include Testicular Germ Cell Tumor and Lung Cancer. Among its related pathways are miRNAs involved in DNA damage response and Mesodermal Commitment Pathway.

Rfam classification for MIR372 Gene

Additional gene information for MIR372 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR372 Gene

Genomics for MIR372 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR372 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J053787 Promoter/Enhancer 1 FANTOM5 Ensembl 250.7 +0.1 118 2 TBP DIDO1 NRF1 TAF7 ZBTB40 L3MBTL2 CREM GABPB1 TRIM24 POLR2A ENSG00000269564 ENSG00000269877 MIR371A MIR371B MIR372 MIR373 RNU6-1041P MIR1283-2 MIR516A2 MIR516A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR372 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR372 Gene

Latest Assembly
chr19:53,787,883-53,787,962
(GRCh38/hg38)
Size:
80 bases
Orientation:
Plus strand

Previous Assembly
chr19:54,291,144-54,291,210
(GRCh37/hg19 by Entrez Gene)
Size:
67 bases
Orientation:
Plus strand

chr19:54,291,144-54,291,210
(GRCh37/hg19 by Ensembl)
Size:
67 bases
Orientation:
Plus strand

Genomic View for MIR372 Gene

Genes around MIR372 on UCSC Golden Path with GeneCards custom track
MIR372 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR372 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR372 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR372 Gene

Proteins for MIR372 Gene

Post-translational modifications for MIR372 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR372 Gene

Domains & Families for MIR372 Gene

Gene Families for MIR372 Gene

genes like me logo Genes that share domains with MIR372: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR372 Gene

Function for MIR372 Gene

Gene Ontology (GO) - Molecular Function for MIR372 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA, HDA 20190813
genes like me logo Genes that share ontologies with MIR372: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR372 Gene

Localization for MIR372 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR372 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR372 Gene

Pathways & Interactions for MIR372 Gene

genes like me logo Genes that share pathways with MIR372: view

Pathways by source for MIR372 Gene

Gene Ontology (GO) - Biological Process for MIR372 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IDA 20190813
GO:0035195 gene silencing by miRNA IDA, IEA, HDA --
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle IDA 20190813
GO:1904046 negative regulation of vascular endothelial growth factor production HMP 18320040
genes like me logo Genes that share ontologies with MIR372: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR372 Gene

Drugs & Compounds for MIR372 Gene

No Compound Related Data Available

Transcripts for MIR372 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR372 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS0000759ECA_9606 miRNA 23 5

RefSeq: NR_029865,

LncBase: hsa-miR-372-3p,

miRBase: MIMAT0000724,

MirGeneDB: Hsa-Mir-430-P6_3p,

TarBase: hsa-miR-372-3p,

URS000075E430_9606 pre_miRNA 67 3

RefSeq: NR_029865,

Ensembl: ENST00000362225 (view in UCSC) ,

miRBase: MI0000780,

URS000075B4E5_9606 miRNA 23 3

RefSeq: NR_029865,

miRBase: MIMAT0026484,

MirGeneDB: Hsa-Mir-430-P6_5p,

URS0000693DE8_9606 pre_miRNA 80 1

Rfam: RF00665,

URS0000EFE703_9606 pre_miRNA 60 1

MirGeneDB: Hsa-Mir-430-P6,

MIR372 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR372 Gene

No ASD Table

Relevant External Links for MIR372 Gene

GeneLoc Exon Structure for
MIR372

No data available for mRNA/cDNA for MIR372 Gene

Expression for MIR372 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR372

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR372 Gene

Orthologs for MIR372 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR372 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-372 30
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir291a 30
  • 54 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves gga-mir-219b 30
  • 31 (a)
OneToMany
Species where no ortholog for MIR372 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR372 Gene

ENSEMBL:
Gene Tree for MIR372 (if available)
TreeFam:
Gene Tree for MIR372 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR372

Paralogs for MIR372 Gene

No data available for Paralogs for MIR372 Gene

Variants for MIR372 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR372 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR372 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
nsv1058969 CNV gain 25217958
nsv1064558 CNV gain 25217958
nsv458781 CNV gain 19166990
nsv580108 CNV gain 21841781

Additional Variant Information for MIR372 Gene

Human Gene Mutation Database (HGMD)
MIR372
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR372
Leiden Open Variation Database (LOVD)
MIR372

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR372 Gene

Disorders for MIR372 Gene

MalaCards: The human disease database

(7) MalaCards diseases for MIR372 Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
testicular germ cell tumor
  • tgct
lung cancer
  • lung cancer, susceptibility to
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
leukemia, acute myeloid
  • aml
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR372

genes like me logo Genes that share disorders with MIR372: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR372 Gene

Publications for MIR372 Gene

  1. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. (PMID: 17695719) Voorhoeve PM … Agami R (Advances in experimental medicine and biology 2007) 3 72
  2. Emerging Role of miR-372 and miR-101a in Head and Neck Squamous Cell Carcinoma. (PMID: 32255289) Moradi N … Dilmaghani NA (Clinical laboratory 2020) 3
  3. The microRNAs miR-302b and miR-372 regulate mitochondrial metabolism via the SLC25A12 transporter, which controls MAVS-mediated antiviral innate immunity. (PMID: 31767682) Yasukawa K … Koshiba T (The Journal of biological chemistry 2020) 3
  4. lncRNA OSER1-AS1 acts as a ceRNA to promote tumorigenesis in hepatocellular carcinoma by regulating miR-372-3p/Rab23 axis. (PMID: 31635804) Fan J … Li P (Biochemical and biophysical research communications 2020) 3
  5. FER1L4/miR-372/E2F1 works as a ceRNA system to regulate the proliferation and cell cycle of glioma cells. (PMID: 30887657) Xia L … Chen G (Journal of cellular and molecular medicine 2019) 3

Products for MIR372 Gene

Sources for MIR372 Gene