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MIR372 Gene(RNA Gene)

MicroRNA 372

GCID:
GC19P053913
GIFtS:
16
Genes Participants
UDN Logo

Aliases for MIR372 Gene

Subcategory (RNA class) for MIR372 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR372 Gene

  • MicroRNA 372 2 3 5
  • Hsa-Mir-372 3
  • MIRN372 3

External Ids for MIR372 Gene

ORGUL Members for MIR372 Gene

Previous HGNC Symbols for MIR372 Gene

  • MIRN372

Previous GeneCards Identifiers for MIR372 Gene

  • GC19P058992
  • GC19P059031
  • GC19P054291
  • GC19P053789
  • GC19P053810
  • GC19P053841
  • GC19P053862
  • GC19P053894
  • GC19P053895
  • GC19P053902

Summaries for MIR372 Gene

Entrez Gene Summary for MIR372 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR372 Gene

MIR372 (MicroRNA 372) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Mesodermal Commitment Pathway and miRNAs involved in DNA damage response.

Additional gene information for MIR372 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR372 Gene

Genomics for MIR372 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR372 Gene

Promoters and enhancers for MIR372 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19I053787 Enhancer 0.6 FANTOM5 550.8 +0.1 54 0 NRF1 ZBTB11 ZBTB40 GTF2A2 DIDO1 GABPB1 TRIM24 CREM MGA ENSG00000269564 ENSG00000269877 GC19P053928 GC19P053932 GC19P053940 GC19P053953 GC19P053959 GC19P053967 MIR371A MIR371B
GH19I053788 Enhancer 0.2 FANTOM5 550.8 +0.8 760 0.2 ENSG00000269564 ENSG00000269877 GC19P053928 GC19P053932 GC19P053940 GC19P053953 GC19P053959 GC19P053967 MIR371A MIR371B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR372 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR372 Gene

Genomic Locations for MIR372 Gene
chr19:53,787,890-53,787,956
(GRCh38/hg38)
Size:
67 bases
Orientation:
Plus strand
chr19:54,291,144-54,291,210
(GRCh37/hg19)

Genomic View for MIR372 Gene

Genes around MIR372 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR372 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR372 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR372 Gene

Proteins for MIR372 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR372 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR372 Gene

Domains & Families for MIR372 Gene

Gene Families for MIR372 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR372: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR372 Gene

Function for MIR372 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Gene Ontology (GO) - Molecular Function for MIR372 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR372: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR372 Gene

Localization for MIR372 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR372 Gene

Pathways & Interactions for MIR372 Gene

genes like me logo Genes that share pathways with MIR372: view

Pathways by source for MIR372 Gene

Interacting Proteins for MIR372 Gene

Gene Ontology (GO) - Biological Process for MIR372 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IDA 20190813
GO:0035195 gene silencing by miRNA IDA 20190813
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle IDA 20190813
genes like me logo Genes that share ontologies with MIR372: view

No data available for SIGNOR curated interactions for MIR372 Gene

Drugs & Compounds for MIR372 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR372 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR372 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR372 Gene

No ASD Table

Relevant External Links for MIR372 Gene

GeneLoc Exon Structure for
MIR372
ECgene alternative splicing isoforms for
MIR372

Expression for MIR372 Gene

Products:

  1. Primer
  2. Gene Expression Assay

NURSA nuclear receptor signaling pathways regulating expression of MIR372 Gene:

MIR372
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR372 Gene

Orthologs for MIR372 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR372 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-372 34
  • 100 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mir291a 34
  • 54 (a)
 ManyToMany
chicken
(Gallus gallus)
 Aves gga-mir-219b 34
  • 31 (a)
 OneToMany
Species where no ortholog for MIR372 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR372 Gene

ENSEMBL:
Gene Tree for MIR372 (if available)
TreeFam:
Gene Tree for MIR372 (if available)

Paralogs for MIR372 Gene

No data available for Paralogs for MIR372 Gene

Variants for MIR372 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MIR372 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1001812818 -- 53,788,443(+) C/A/T downstream_transcript_variant
rs1002745282 -- 53,786,652(+) C/T upstream_transcript_variant
rs1002753504 -- 53,786,947(+) A/G/T upstream_transcript_variant
rs1003751295 -- 53,786,888(+) G/A upstream_transcript_variant
rs1004685112 -- 53,787,689(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR372 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
nsv1058969 CNV gain 25217958
nsv1064558 CNV gain 25217958
nsv458781 CNV gain 19166990
nsv580108 CNV gain 21841781

Additional Variant Information for MIR372 Gene

Human Gene Mutation Database (HGMD)
MIR372
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR372

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR372 Gene

Disorders for MIR372 Gene

Additional Disease Information for MIR372

Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR372 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR372 Gene

Publications for MIR372 Gene

  1. Repression of MicroRNA-372 by Arsenic Sulphide Inhibits Prostate Cancer Cell Proliferation and Migration through Regulation of large tumour suppressor kinase 2. (PMID: 27730751) Cao H … Chen L (Basic & clinical pharmacology & toxicology 2017) 3 58
  2. The role of miR-372 in ovarian carcinoma cell proliferation. (PMID: 28456593) Guan X … Zhao Y (Gene 2017) 3 58
  3. Downregulation of ULK1 by microRNA-372 inhibits the survival of human pancreatic adenocarcinoma cells. (PMID: 28677209) Chen H … Sun W (Cancer science 2017) 3 58
  4. A pipeline to quantify serum and cerebrospinal fluid microRNAs for diagnosis and detection of relapse in paediatric malignant germ-cell tumours. (PMID: 26671749) Murray MJ … Coleman N (British journal of cancer 2016) 3 58
  5. Serum miR-372 is a Diagnostic and Prognostic Biomarker in Patients with Early Colorectal Cancer. (PMID: 26179262) Yu J … Zhu X (Anti-cancer agents in medicinal chemistry 2016) 3 58

Products for MIR372 Gene

Sources for MIR372 Gene

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