microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR371A Gene

Subcategory (RNA class) for MIR371A Gene

miRNA

Quality Score for this RNA gene is

16

Aliases for MIR371A Gene

  • MicroRNA 371a 2 3 5
  • Hsa-MiR-371a-5p 168 179
  • MicroRNA 371 2 3
  • Hsa-MiR-371a-3p 179
  • Hsa-Mir-371a 3
  • MIMAT0000723 53
  • MIMAT0004687 53
  • Hsa-Mir-371 3
  • MI0000779 53
  • MIRN371 3
  • MIR371A 2
  • RF00665 174
  • MIR371 3

External Ids for MIR371A Gene

Previous HGNC Symbols for MIR371A Gene

  • MIRN371
  • MIR371

Previous GeneCards Identifiers for MIR371A Gene

  • GC19P054307
  • GC19P054333
  • GC19P054354
  • GC19P054431
  • GC19P054509

Summaries for MIR371A Gene

Entrez Gene Summary for MIR371A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR371A Gene

MIR371A (MicroRNA 371a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR371A include Testicular Germ Cell Tumor and Germ Cell Cancer. Among its related pathways are miRNAs involved in DNA damage response.

Rfam classification for MIR371A Gene

Additional gene information for MIR371A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR371A Gene

Genomics for MIR371A Gene

GeneHancer (GH) Regulatory Elements for MIR371A Gene

Promoters and enhancers for MIR371A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J053787 Promoter/Enhancer 0.9 FANTOM5 Ensembl 750.6 +0.3 333 2 ZBTB40 L3MBTL2 TRIM24 NRF1 MGA ZBTB11 GTF2A2 CREM POLR2A TAF7 ENSG00000269564 ENSG00000269877 MIR371A MIR371B MIR372 MIR373 MIR1283-2 MIR516A2 RNU6-1041P MIR516A1
GH19J053784 Enhancer 1.1 FANTOM5 Ensembl ENCODE 0.6 -2.4 -2383 1.8 TCF7L2 NR2F1 NR2F6 ZNF384 GATAD2A RXRB LEF1 TCF7 ZBTB26 FOXA2 ZNF331 ZNF813 DPRX ZNF765 MIR371A ENSG00000238150 lnc-MYADM-5
GH19J053780 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -5.7 -5734 3.7 POU5F1 SP1 CBFA2T2 RAD51 BACH1 POLR2A NANOG ENSG00000213777 ZNF765 ZNF761 ZNF813 ENSG00000238150 MIR371A lnc-MYADM-5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR371A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR371A Gene

Genomic Locations for MIR371A Gene
chr19:53,787,668-53,787,748
(GRCh38/hg38)
Size:
81 bases
Orientation:
Plus strand
chr19:54,290,929-54,290,995
(GRCh37/hg19)
Size:
67 bases
Orientation:
Plus strand

Genomic View for MIR371A Gene

Genes around MIR371A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR371A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR371A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR371A Gene

Proteins for MIR371A Gene

Post-translational modifications for MIR371A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR371A Gene

Domains & Families for MIR371A Gene

Gene Families for MIR371A Gene

genes like me logo Genes that share domains with MIR371A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR371A Gene

Function for MIR371A Gene

Phenotypes From GWAS Catalog for MIR371A Gene

Gene Ontology (GO) - Molecular Function for MIR371A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 30451334
genes like me logo Genes that share ontologies with MIR371A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR371A Gene

Localization for MIR371A Gene

Gene Ontology (GO) - Cellular Components for MIR371A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR371A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR371A Gene

Pathways & Interactions for MIR371A Gene

PathCards logo

SuperPathways for MIR371A Gene

genes like me logo Genes that share pathways with MIR371A: view

Pathways by source for MIR371A Gene

1 BioSystems pathway for MIR371A Gene

Gene Ontology (GO) - Biological Process for MIR371A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR371A: view

No data available for SIGNOR curated interactions for MIR371A Gene

Drugs & Compounds for MIR371A Gene

No Compound Related Data Available

Transcripts for MIR371A Gene

mRNA/cDNA for MIR371A Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(4) RNACentral transcripts :
(2) TarBase transcripts :
(1) Rfam transcripts :
(3) miRBase transcripts :
(1) LncBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR371A Gene

No ASD Table

Relevant External Links for MIR371A Gene

GeneLoc Exon Structure for
MIR371A
ECgene alternative splicing isoforms for
MIR371A

Expression for MIR371A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR371A Gene:

MIR371A
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR371A Gene

Orthologs for MIR371A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR371A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-371 33
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-371 33
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir295 33
  • 68 (a)
OneToMany
Mir293 33
  • 59 (a)
OneToMany
Mir290 33
  • 57 (a)
OneToMany
Mir292 33
  • 56 (a)
OneToMany
Mir291b 33
  • 54 (a)
OneToMany
Mir294 33
  • 49 (a)
OneToMany
dog
(Canis familiaris)
Mammalia cfa-mir-371 33 33
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves gga-mir-219b 33
  • 26 (a)
OneToMany
Species where no ortholog for MIR371A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR371A Gene

ENSEMBL:
Gene Tree for MIR371A (if available)
TreeFam:
Gene Tree for MIR371A (if available)

Paralogs for MIR371A Gene

No data available for Paralogs for MIR371A Gene

Variants for MIR371A Gene

Sequence variations from dbSNP and Humsavar for MIR371A Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1002745282 -- 53,786,652(+) C/T upstream_transcript_variant
rs1002753504 -- 53,786,947(+) A/G/T upstream_transcript_variant
rs1002875412 -- 53,785,866(+) C/G upstream_transcript_variant
rs1003751295 -- 53,786,888(+) G/A upstream_transcript_variant
rs1004685112 -- 53,787,689(+) G/C non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR371A Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
nsv1058969 CNV gain 25217958
nsv1064558 CNV gain 25217958
nsv458781 CNV gain 19166990
nsv580108 CNV gain 21841781

Additional Variant Information for MIR371A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR371A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR371A Gene

Disorders for MIR371A Gene

MalaCards: The human disease database

(8) MalaCards diseases for MIR371A Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
testicular germ cell tumor
  • tgct
germ cell cancer
  • germ cell neoplasm
kawasaki disease
  • kd
germ cell and embryonal cancer
  • germ cell and embryonal neoplasm
mixed cell type cancer
  • malignant mixed cancer
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR371A

genes like me logo Genes that share disorders with MIR371A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR371A Gene

Publications for MIR371A Gene

  1. Genome-wide identification of microRNAs regulating the human prion protein. (PMID: 30451334) Pease D … Aguzzi A (Brain pathology (Zurich, Switzerland) 2019) 3 56
  2. Germ cell tumour subtypes display differential expression of microRNA371a-3p. (PMID: 29685967) Vilela-Salgueiro B … Jerónimo C (Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2018) 3 56
  3. The Novel Biomarker of Germ Cell Tumours, Micro-RNA-371a-3p, Has a Very Rapid Decay in Patients with Clinical Stage 1. (PMID: 29698973) Radtke A … Dieckmann KP (Urologia internationalis 2018) 3 56
  4. MiR-371a-3p Serum Levels Are Increased in Recurrence of Testicular Germ Cell Tumor Patients. (PMID: 30321995) Terbuch A … Pichler M (International journal of molecular sciences 2018) 3 56
  5. Exosome miR-371b-5p promotes proliferation of lung alveolar progenitor type II cells by using PTEN to orchestrate the PI3K/Akt signaling. (PMID: 28595637) Quan Y … Wang D (Stem cell research & therapy 2017) 3 56

Products for MIR371A Gene

Sources for MIR371A Gene