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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR370 (MicroRNA 370) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR370 include Cholangiocarcinoma and Oral Squamous Cell Carcinoma. Among its related pathways are Parkinsons Disease Pathway.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | HDA | 26646931 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Parkinsons Disease Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IEA | -- |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00004900F1_9606 | miRNA | 22 | 5 |
RefSeq: NR_029863, miRBase: MIMAT0000722, MirGeneDB: Hsa-Mir-370_3p, TarBase: hsa-miR-370-3p, |
URS000075B235_9606 | precursor_RNA | 75 | 4 |
RefSeq: NR_029863, Ensembl: ENST00000362135 (view in UCSC) , miRBase: MI0000778, |
URS000075E3E2_9606 | miRNA | 22 | 4 |
RefSeq: NR_029863, miRBase: MIMAT0026483, MirGeneDB: Hsa-Mir-370_5p, |
URS00007281EA_9606 | precursor_RNA | 79 | 1 |
Rfam: RF00740, |
URS0001BC3E4D_9606 | pre_miRNA | 79 | 1 |
Rfam: RF00740, |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-370 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | bta-mir-370 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | cfa-mir-370 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mir370 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1970n100 | CNV | gain | 25217958 |
dgv1971n100 | CNV | loss | 25217958 |
dgv1972n100 | CNV | loss | 25217958 |
esv3635518 | CNV | gain | 21293372 |
nsv1052082 | CNV | loss | 25217958 |
nsv565859 | CNV | gain | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
cholangiocarcinoma |
|
|
oral squamous cell carcinoma |
|
|
prostate cancer |
|