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MIR370 Gene(RNA Gene)

MicroRNA 370

GCID:
GC14P103090
GIFtS:
20
Genes Participants
UDN Logo

Aliases for MIR370 Gene

Subcategory (RNA class) for MIR370 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR370 Gene

  • MicroRNA 370 2 3 5
  • Hsa-Mir-370 3
  • Mir-370 3
  • MIRN370 3

External Ids for MIR370 Gene

ORGUL Members for MIR370 Gene

Previous HGNC Symbols for MIR370 Gene

  • MIRN370

Previous GeneCards Identifiers for MIR370 Gene

  • GC14P100468
  • GC14P100850
  • GC14P101377
  • GC14P101061
  • GC14P101285
  • GC14P101914
  • GC14P102222
  • GC14P102389
  • GC14P102568
  • GC14P102740
  • GC14P102914

Summaries for MIR370 Gene

Entrez Gene Summary for MIR370 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR370 Gene

MIR370 (MicroRNA 370) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR370 include Cholangiocarcinoma and Oral Squamous Cell Carcinoma. Among its related pathways are Parkinsons Disease Pathway.

Additional gene information for MIR370 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR370 Gene

Genomics for MIR370 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR370 Gene

Promoters and enhancers for MIR370 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH14J100819 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -84.6 -84603 13.4 ELF3 PKNOX1 FOXA2 ZSCAN4 NFXL1 ZNF48 RAD21 RFX5 ZNF280A SLC30A9 ENSG00000274884 DLK1 MEG3 MIR493 MIR337 MIR431 MIR127 MIR136 MIR433 RTL1
GH14J100833 Enhancer 0.9 ENCODE dbSUPER 10.1 -72.3 -72344 10.6 BCOR ESRRA FOXA2 ZBTB21 ZMYM3 ZIC2 TEAD3 ZFHX2 SCRT2 FOSL2 MEG3 MIR493 MIR337 MIR127 MIR431 MIR433 RTL1 MIR136 SNORD112 MIR370
GH14J101215 Enhancer 0.8 ENCODE 10.2 +305.6 305585 2.8 FOXA2 ARID4B RAD21 ZNF48 ZSCAN9 RARA CREM RXRA CEBPB NR2F2 LOC100128373 SNORD113-3 SNORD113-8 SNORD113-9 SNORD113-4 SNORD113-6 SNORD113-7 MIR543 ENSG00000222185 ENSG00000222095
GH14J100883 Enhancer 0.5 ENCODE dbSUPER 10.5 -26.3 -26306 2.8 ZKSCAN1 GC14P103289 MIR127 MIR136 MIR432 RTL1 MEG3 MIR370 SNORD113-1 SNORD113-2 PPP2R5C
GH14J101176 Enhancer 0.5 ENCODE 9.6 +266.2 266227 2 ZNF680 ZFP3 RCOR1 CHD2 MIR154 MIR377 MIR496 MIR134 MIR323B MIR485 MIR487A SNORD113-2 SNORD113-3 ENSG00000222185
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR370 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR370 Gene

Genomic Locations for MIR370 Gene
chr14:100,911,139-100,911,213
(GRCh38/hg38)
Size:
75 bases
Orientation:
Plus strand
chr14:101,377,476-101,377,550
(GRCh37/hg19)
Size:
75 bases
Orientation:
Plus strand

Genomic View for MIR370 Gene

Genes around MIR370 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR370 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR370 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR370 Gene

Proteins for MIR370 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR370 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR370 Gene

Domains & Families for MIR370 Gene

Gene Families for MIR370 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR370: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR370 Gene

Function for MIR370 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for MIR370 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR370 Gene

Localization for MIR370 Gene

Gene Ontology (GO) - Cellular Components for MIR370 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR370: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR370 Gene

Pathways & Interactions for MIR370 Gene

SuperPathways for MIR370 Gene

PathCards logo More details on SuperPathways for MIR370
SuperPathway Contained pathways
1 Parkinsons Disease Pathway
Parkinsons Disease Pathway
-
genes like me logo Genes that share pathways with MIR370: view

Pathways by source for MIR370 Gene

1 BioSystems pathway for MIR370 Gene

Interacting Proteins for MIR370 Gene

Gene Ontology (GO) - Biological Process for MIR370 Gene

None

No data available for SIGNOR curated interactions for MIR370 Gene

Drugs & Compounds for MIR370 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR370 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR370 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR370 Gene

No ASD Table

Relevant External Links for MIR370 Gene

GeneLoc Exon Structure for
MIR370
ECgene alternative splicing isoforms for
MIR370

Expression for MIR370 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR370 Gene

mRNA expression in normal human tissues for MIR370 Gene
mRNA expression by GTEx for MIR370 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR370 Gene:

MIR370
genes like me logo Genes that share expression patterns with MIR370: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR370 Gene

Orthologs for MIR370 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR370 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-370 34
  • 100 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia bta-mir-370 34
  • 97 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia cfa-mir-370 34
  • 92 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mir370 34
  • 90 (a)
 OneToOne
Species where no ortholog for MIR370 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR370 Gene

ENSEMBL:
Gene Tree for MIR370 (if available)
TreeFam:
Gene Tree for MIR370 (if available)

Paralogs for MIR370 Gene

No data available for Paralogs for MIR370 Gene

Variants for MIR370 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MIR370 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000087724 -- 100,911,338(+) G/T downstream_transcript_variant
rs1000165971 -- 100,911,500(+) G/T downstream_transcript_variant
rs1001330648 -- 100,909,477(+) C/G upstream_transcript_variant
rs1001719131 -- 100,911,533(+) C/T downstream_transcript_variant
rs1002066638 -- 100,911,309(+) TTTTTTTTT/TTTTTTTT/TTTTTTTTTT downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR370 Gene

Variant ID Type Subtype PubMed ID
nsv565859 CNV gain 21841781
nsv1052082 CNV loss 25217958
esv3635518 CNV gain 21293372
dgv1972n100 CNV loss 25217958
dgv1971n100 CNV loss 25217958
dgv1970n100 CNV gain 25217958

Additional Variant Information for MIR370 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR370

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR370 Gene

Disorders for MIR370 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR370 Gene - From: miR2Disease and GeneCards

Disorder Aliases PubMed IDs
cholangiocarcinoma
  • cholangiocarcinoma, susceptibility to
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
prostate cancer
  • prostate cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR370

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR370: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR370 Gene

Publications for MIR370 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 44 58
  2. miR-370 suppresses HBV gene expression and replication by targeting nuclear factor IA. (PMID: 27664977) Fan H … Tang H (Journal of medical virology 2017) 3 58
  3. Effects of miR-1236-3p and miR-370-5p on activation of p21 in various tumors and its inhibition on the growth of lung cancer cells. (PMID: 28631573) Li C … Chen Z (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
  4. MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation. (PMID: 28552654) Zeng L … Ning B (Biochemical pharmacology 2017) 3 58
  5. miR-370 regulates cell proliferation and migration by targeting EGFR in gastric cancer. (PMID: 28534999) Ning T … Ba Y (Oncology reports 2017) 3 58

Products for MIR370 Gene

Sources for MIR370 Gene

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