microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR370 Gene

Subcategory (RNA class) for MIR370 Gene

miRNA

Number of RNA Genes sources:

5 / 17

Aliases for MIR370 Gene

  • MicroRNA 370 2 3 5
  • Hsa-Mir-370 2 3 178
  • MIR370 2 5
  • Hsa-MiR-370-3p 173
  • MIMAT0000722 50
  • MIMAT0026483 50
  • MI0000778 50
  • MIRN370 3
  • Mir-370 3
  • RF00740 168

External Ids for MIR370 Gene

Previous HGNC Symbols for MIR370 Gene

  • MIRN370

Previous GeneCards Identifiers for MIR370 Gene

  • GC14P100468
  • GC14P100850
  • GC14P101377
  • GC14P101061
  • GC14P101285
  • GC14P103470
  • GC14P103664
  • GC14P103871
  • GC14P104253
  • GC14P101914
  • GC14P102222
  • GC14P102389
  • GC14P102568
  • GC14P102740
  • GC14P102914
  • GC14P103090
  • GC14P103288

Summaries for MIR370 Gene

Entrez Gene Summary for MIR370 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR370 Gene

MIR370 (MicroRNA 370) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR370 include Cholangiocarcinoma and Oral Squamous Cell Carcinoma. Among its related pathways are Parkinsons Disease Pathway.

Rfam classification for MIR370 Gene

Additional gene information for MIR370 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR370 Gene

Genomics for MIR370 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR370 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J100911 Enhancer 0.4 Ensembl 600.7 +0.8 762 0.2 ZNF692 ZFHX2 EGR2 MIR370 lnc-RTL1-10 RTL1 MEG8 ENSG00000258399 DIO3
GH14J100912 Enhancer 0.3 Ensembl 600.7 +1.4 1362 0.2 SCRT2 MIR370 lnc-RTL1-10 RTL1 MEG8 ENSG00000258399 DIO3
GH14J100819 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.9 -84.6 -84603 13.4 HNRNPL CREB1 GATAD2A ATF7 REST RFX5 CTCF RCOR2 ZSCAN4 RBFOX2 MEG3 ENSG00000274884 GQ183494 DLK1 MIR493 MIR337 MIR431 MIR127 MIR136 MIR433
GH14J100833 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.1 -72.2 -72187 10.9 ZNF629 KDM1A RCOR2 ZIC2 CEBPA SCRT2 CEBPB TSHZ1 ESRRA FOS MEG3 MIR493 MIR337 MIR127 MIR431 MIR433 MIR136 RTL1 SNORD112 MIR370
GH14J101232 Enhancer 0.9 Ensembl CraniofacialAtlas 10.8 +323.0 322961 3.4 HNRNPL GATAD2A CTCF ZIC2 ZSCAN4 RXRB REST RAD21 MNT SMARCA5 MIR370 MIR655 MIR1185-2 MIR381 MIR487B MIR539 MIR544A MIR889 MIR1185-1 MIR300
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR370 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR370 Gene

Genomic Locations for MIR370 Gene
chr14:100,911,139-100,911,217
(GRCh38/hg38)
Size:
79 bases
Orientation:
Plus strand
chr14:101,377,476-101,377,550
(GRCh37/hg19)
Size:
75 bases
Orientation:
Plus strand

Genomic View for MIR370 Gene

Genes around MIR370 on UCSC Golden Path with GeneCards custom track
MIR370 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR370 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR370 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR370 Gene

Proteins for MIR370 Gene

Post-translational modifications for MIR370 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR370 Gene

Domains & Families for MIR370 Gene

Gene Families for MIR370 Gene

HGNC:
genes like me logo Genes that share domains with MIR370: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR370 Gene

Function for MIR370 Gene

Phenotypes From GWAS Catalog for MIR370 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR370 Gene

Localization for MIR370 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR370 gene
Compartment Confidence
extracellular 2
cytoskeleton 2
nucleus 2
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR370 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR370: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR370 Gene

Pathways & Interactions for MIR370 Gene

PathCards logo

SuperPathways for MIR370 Gene

SuperPathway Contained pathways
1 Parkinsons Disease Pathway
genes like me logo Genes that share pathways with MIR370: view

Pathways by source for MIR370 Gene

1 BioSystems pathway for MIR370 Gene

Gene Ontology (GO) - Biological Process for MIR370 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR370: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR370 Gene

Drugs & Compounds for MIR370 Gene

No Compound Related Data Available

Transcripts for MIR370 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR370 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075B235_9606 precursor_RNA 75 5

HGNC: 31784,

RefSeq: NR_029863,

Ensembl: ENST00000362135 (view in UCSC) ,

miRBase: MI0000778,

ENA: LM608698.1:1..75:precursor_RNA,

URS00004900F1_9606 miRNA 22 5

RefSeq: NR_029863,

miRBase: MIMAT0000722,

MirGeneDB: Hsa-Mir-370_3p,

TarBase: hsa-miR-370-3p,

ENA: LM379231.1:1..22:ncRNA, LM608698.1:48..69:ncRNA,

URS000075E3E2_9606 miRNA 22 4

RefSeq: NR_029863,

miRBase: MIMAT0026483,

MirGeneDB: Hsa-Mir-370_5p,

ENA: LM383148.1:1..22:ncRNA, LM608698.1:13..34:ncRNA,

URS00007281EA_9606 precursor_RNA 79 1

Rfam: RF00740,

URS0000EFE467_9606 precursor_RNA 58 1

MirGeneDB: Hsa-Mir-370,

MIR370 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR370 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR370 Gene

No ASD Table

Relevant External Links for MIR370 Gene

GeneLoc Exon Structure for
MIR370

Expression for MIR370 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR370 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR370

genes like me logo Genes that share expression patterns with MIR370: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR370 Gene

Orthologs for MIR370 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR370 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-370 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-370 31
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-370 31
  • 92 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir370 31
  • 90 (a)
OneToOne
Species where no ortholog for MIR370 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR370 Gene

ENSEMBL:
Gene Tree for MIR370 (if available)
TreeFam:
Gene Tree for MIR370 (if available)

Paralogs for MIR370 Gene

No data available for Paralogs for MIR370 Gene

Variants for MIR370 Gene

Additional dbSNP identifiers (rs#s) for MIR370 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR370 Gene

Variant ID Type Subtype PubMed ID
dgv1970n100 CNV gain 25217958
dgv1971n100 CNV loss 25217958
dgv1972n100 CNV loss 25217958
esv3635518 CNV gain 21293372
nsv1052082 CNV loss 25217958
nsv565859 CNV gain 21841781

Additional Variant Information for MIR370 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR370

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR370 Gene

Disorders for MIR370 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR370 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cholangiocarcinoma
  • cca
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
prostate cancer
  • prostate cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR370

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR370: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR370 Gene

Publications for MIR370 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 41
  2. Circular RNA circ_0003204 inhibits proliferation, migration and tube formation of endothelial cell in atherosclerosis via miR-370-3p/TGFβR2/phosph-SMAD3 axis. (PMID: 31900142) Zhang S … Wang A (Journal of biomedical science 2020) 3
  3. MicroRNA-370 functions as a tumor suppressor in hepatocellular carcinoma via inhibition of the MAPK/JNK signaling pathway by targeting BEX2. (PMID: 31530937) Wang X … Zang Y (Journal of human genetics 2019) 3
  4. miR-370 inhibits the angiogenic activity of endothelial cells by targeting smoothened (SMO) and bone morphogenetic protein (BMP)-2. (PMID: 30865837) Gu Y … Laschke MW (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019) 3
  5. CXCL12-regulated miR-370-3p functions as a tumor suppressor gene by targeting HMGA2 in nonfunctional pituitary adenomas. (PMID: 30853598) Cai F … Zhang J (Molecular and cellular endocrinology 2019) 3

Products for MIR370 Gene

Sources for MIR370 Gene