microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR369 Gene

Subcategory (RNA class) for MIR369 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR369 Gene

  • MicroRNA 369 2 3 5
  • Hsa-MiR-369-5p 163 173
  • Hsa-MiR-369-3p 163 173
  • Hsa-Mir-369 2 3
  • MIR369 2 5
  • Hsa-Mir-154-P5 178
  • MIMAT0000721 50
  • MIMAT0001621 50
  • MIRN369-3 3
  • MI0000777 50
  • MIR369-3 3
  • MIRN369 3
  • Mir-369 3
  • RF00641 168

External Ids for MIR369 Gene

Previous HGNC Symbols for MIR369 Gene

  • MIRN369

Previous GeneCards Identifiers for MIR369 Gene

  • GC14P100842
  • GC14P100932
  • GC14P101533
  • GC14P101561
  • GC14P101594
  • GC14P101633
  • GC14P101661
  • GC14P101695
  • GC14P101733
  • GC14P101773
  • GC14P101831
  • GC14P101971
  • GC14P102168
  • GC14P101275
  • GC14P101894
  • GC14P103612
  • GC14P103829
  • GC14P104103
  • GC14P104447
  • GC14P102208
  • GC14P102375
  • GC14P102555
  • GC14P102727
  • GC14P102897
  • GC14P103073
  • GC14P103269
  • GC14P103432

Summaries for MIR369 Gene

Entrez Gene Summary for MIR369 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR369 Gene

MIR369 (MicroRNA 369) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR369 include Muscular Dystrophy, Duchenne Type and Nemaline Myopathy.

Rfam classification for MIR369 Gene

Additional gene information for MIR369 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR369 Gene

Genomics for MIR369 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR369 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J101096 Enhancer 0.9 FANTOM5 Ensembl ENCODE 11.4 +32.7 32674 3.3 ATF7 KDM1A SPI1 ATF4 MAFK JUN POLR2A RTL1 ENSG00000230805 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154
GH14J101095 Enhancer 0.2 Ensembl 11.4 +30.1 30108 0.2 MIR410 MIR656 MEG9 MIR369 MIR409 MIR412 MIR541 MIR377 MIR154 MIR323B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR369 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR369 Gene

Genomic Locations for MIR369 Gene
chr14:101,065,593-101,065,671
(GRCh38/hg38)
Size:
79 bases
Orientation:
Plus strand
chr14:101,531,918-101,532,024
(GRCh37/hg19)
Size:
107 bases
Orientation:
Plus strand

Genomic View for MIR369 Gene

Genes around MIR369 on UCSC Golden Path with GeneCards custom track
MIR369 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR369 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR369 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR369 Gene

Proteins for MIR369 Gene

Post-translational modifications for MIR369 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR369 Gene

Domains & Families for MIR369 Gene

Gene Families for MIR369 Gene

genes like me logo Genes that share domains with MIR369: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR369 Gene

Function for MIR369 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR369 Gene

Localization for MIR369 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR369 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR369 Gene

Pathways & Interactions for MIR369 Gene

PathCards logo

SuperPathways for MIR369 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR369 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR369: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR369 Gene

Drugs & Compounds for MIR369 Gene

No Compound Related Data Available

Transcripts for MIR369 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR369 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000442B0D_9606 miRNA 21 6

RefSeq: NR_029862,

LncBase: hsa-miR-369-3p,

miRBase: MIMAT0000721,

MirGeneDB: Hsa-Mir-154-P5_3p,

TarBase: hsa-miR-369-3p,

ENA: LM379230.1:1..21:ncRNA, LM608697.1:44..64:ncRNA,

URS000075D5A7_9606 precursor_RNA 70 5

HGNC: 31783,

RefSeq: NR_029862,

Ensembl: ENST00000362155 (view in UCSC) ,

miRBase: MI0000777,

ENA: LM608697.1:1..70:precursor_RNA,

URS00002A71AD_9606 miRNA 22 5

RefSeq: NR_029862,

LncBase: hsa-miR-369-5p,

miRBase: MIMAT0001621,

TarBase: hsa-miR-369-5p,

ENA: LM379529.1:1..22:ncRNA, LM608697.1:9..30:ncRNA,

URS000021C7D8_9606 precursor_RNA 79 1

Rfam: RF00641,

URS0000EFC2B1_9606 precursor_RNA 57 1

MirGeneDB: Hsa-Mir-154-P5,

MIR369 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR369 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR369 Gene

No ASD Table

Relevant External Links for MIR369 Gene

GeneLoc Exon Structure for
MIR369

Expression for MIR369 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR369 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR369

genes like me logo Genes that share expression patterns with MIR369: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR369 Gene

Orthologs for MIR369 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR369 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-369 31
  • 97 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir369 31
  • 96 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-369 31
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-369 31
  • 93 (a)
OneToOne
Species where no ortholog for MIR369 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR369 Gene

ENSEMBL:
Gene Tree for MIR369 (if available)
TreeFam:
Gene Tree for MIR369 (if available)

Paralogs for MIR369 Gene

No data available for Paralogs for MIR369 Gene

Variants for MIR369 Gene

Additional dbSNP identifiers (rs#s) for MIR369 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR369 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv509551 CNV insertion 20534489
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Additional Variant Information for MIR369 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR369

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR369 Gene

Disorders for MIR369 Gene

MalaCards: The human disease database

(9) MalaCards diseases for MIR369 Gene - From: miR2Disease and DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR369

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MIR369: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR369 Gene

Publications for MIR369 Gene

  1. Association between hsa-mir-146a genotype and tumor age-of-onset in BRCA1/BRCA2-negative familial breast and ovarian cancer patients. (PMID: 20810544) Pastrello C … Maestro R (Carcinogenesis 2010) 3 41
  2. Consistency analysis of microRNA-arm expression reveals microRNA-369-5p/3p as tumor suppressors in gastric cancer. (PMID: 31162777) Dong L … Yu J (Molecular oncology 2019) 3
  3. Downregulation of TSPAN13 by miR-369-3p inhibits cell proliferation in papillary thyroid cancer (PTC). (PMID: 30114378) Li P … Wang Z (Bosnian journal of basic medical sciences 2019) 3
  4. LncRNA OIP5-AS1 regulates radioresistance by targeting DYRK1A through miR-369-3p in colorectal cancer cells. (PMID: 29773344) Zou Y … Xiong H (European journal of cell biology 2018) 3
  5. Upregulation of MiR-369-3p suppresses cell migration and proliferation by targeting SOX4 in Hirschsprung's disease. (PMID: 28412032) Pan W … Ge X (Journal of pediatric surgery 2017) 3

Products for MIR369 Gene

Sources for MIR369 Gene