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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR3678 (MicroRNA 3678) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH17J075401 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 250.7 | -1.7 | -1659 | 5.2 | CHD2 TBP ZBTB10 SP1 MXD4 ZNF217 MNT DEK IKZF1 BRCA1 | GRB2 MIR3678 lnc-CASKIN2-5 NUP85 UNK GGA3 ENSG00000266980 CDK3 NAT9 ENSG00000267342 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903561 | extracellular vesicle | HDA | 28798470 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075DF0D_9606 | precursor_RNA | 94 | 4 |
RefSeq: NR_037449, Ensembl: ENST00000578455 (view in UCSC) , miRBase: MI0016079, |
URS000075BC79_9606 | miRNA | 22 | 3 |
RefSeq: NR_037449, miRBase: MIMAT0018103, |
URS000075A9CF_9606 | miRNA | 20 | 3 |
RefSeq: NR_037449, miRBase: MIMAT0018102, ENA: LM611193.1:9..28:ncRNA, |
No disorders were found for MIR3678 Gene.