microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR365B Gene

Subcategory (RNA class) for MIR365B Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR365B Gene

  • MicroRNA 365b 2 3 5
  • Hsa-MiR-365a-3p 168 179
  • Hsa-MiR-365b-3p 168 179
  • Hsa-MiR-365b-5p 168 179
  • MicroRNA 365-2 2 3
  • Hsa-Mir-365-2 3
  • Hsa-Mir-365b 3
  • MIMAT0022833 53
  • MIMAT0022834 53
  • MIMAT0000710 53
  • MIRN365-2 3
  • MI0000769 53
  • Mir-365b 3
  • MIR365-2 3
  • MIR365B 2
  • RF00659 174

External Ids for MIR365B Gene

Previous HGNC Symbols for MIR365B Gene

  • MIRN365-2
  • MIR365-2

Previous GeneCards Identifiers for MIR365B Gene

  • GC17P029903
  • GC17P029904
  • GC17P029910
  • GC17P029915
  • GC17P029919
  • GC17P031576
  • GC17P031577
  • GC17P031578

Summaries for MIR365B Gene

Entrez Gene Summary for MIR365B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR365B Gene

MIR365B (MicroRNA 365b) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR365B Gene

Additional gene information for MIR365B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR365B Gene

Genomics for MIR365B Gene

Genomic Locations for MIR365B Gene

Genomic Locations for MIR365B Gene
chr17:31,575,411-31,575,521
(GRCh38/hg38)
Size:
111 bases
Orientation:
Plus strand
chr17:29,902,430-29,902,540
(GRCh37/hg19)
Size:
111 bases
Orientation:
Plus strand

Genomic View for MIR365B Gene

Genes around MIR365B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR365B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR365B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR365B Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR365B Gene

Proteins for MIR365B Gene

Post-translational modifications for MIR365B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR365B Gene

Domains & Families for MIR365B Gene

Gene Families for MIR365B Gene

genes like me logo Genes that share domains with MIR365B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR365B Gene

Function for MIR365B Gene

Phenotypes From GWAS Catalog for MIR365B Gene

Gene Ontology (GO) - Molecular Function for MIR365B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21518763
genes like me logo Genes that share ontologies with MIR365B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR365B Gene

Localization for MIR365B Gene

Gene Ontology (GO) - Cellular Components for MIR365B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR365B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR365B Gene

Pathways & Interactions for MIR365B Gene

PathCards logo

SuperPathways for MIR365B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR365B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
GO:0035278 miRNA mediated inhibition of translation IDA 21518763
genes like me logo Genes that share ontologies with MIR365B: view

No data available for Pathways by source and SIGNOR curated interactions for MIR365B Gene

Drugs & Compounds for MIR365B Gene

No Compound Related Data Available

Transcripts for MIR365B Gene

mRNA/cDNA for MIR365B Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(5) RNACentral transcripts :
(10) ENA transcripts :
(3) TarBase transcripts :
(3) LncBase transcripts :
(4) miRBase transcripts :
(1) Rfam transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR365B Gene

No ASD Table

Relevant External Links for MIR365B Gene

GeneLoc Exon Structure for
MIR365B
ECgene alternative splicing isoforms for
MIR365B

Expression for MIR365B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR365B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR365B Gene:

MIR365B
genes like me logo Genes that share expression patterns with MIR365B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR365B Gene

Orthologs for MIR365B Gene

Evolution for MIR365B Gene

ENSEMBL:
Gene Tree for MIR365B (if available)
TreeFam:
Gene Tree for MIR365B (if available)

No data available for Orthologs for MIR365B Gene

Paralogs for MIR365B Gene

No data available for Paralogs for MIR365B Gene

Variants for MIR365B Gene

Sequence variations from dbSNP and Humsavar for MIR365B Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000742626 -- 31,574,514(+) G/A upstream_transcript_variant
rs1003620236 -- 31,573,729(+) A/G upstream_transcript_variant
rs1003979043 -- 31,573,976(+) G/A upstream_transcript_variant
rs1005473010 -- 31,575,169(+) G/A upstream_transcript_variant
rs1007183839 -- 31,574,070(+) C/T upstream_transcript_variant

Additional Variant Information for MIR365B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR365B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR365B Gene

Disorders for MIR365B Gene

Additional Disease Information for MIR365B

No disorders were found for MIR365B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR365B Gene

Publications for MIR365B Gene

  1. Novel mechanism of miRNA-365-regulated trophoblast apoptosis in recurrent miscarriage. (PMID: 28393453) Zhao W … Zhong TY (Journal of cellular and molecular medicine 2017) 3 56
  2. MicroRNA-365 inhibits proliferation, migration and invasion of glioma by targeting PIK3R3. (PMID: 28260020) Zhu Y … Xu S (Oncology reports 2017) 3 56
  3. Circulating microRNAs as Potential Biomarkers of Endothelial Dysfunction in Obese Children. (PMID: 26270249) Khalyfa A … Gozal D (Chest 2016) 3 56
  4. miR‑365 overexpression promotes cell proliferation and invasion by targeting ADAMTS-1 in breast cancer. (PMID: 25998153) Li M … Zhao G (International journal of oncology 2015) 3 56
  5. Serum microRNA-365 in combination with its target gene TTF-1 as a non-invasive prognostic marker for non-small cell lung cancer. (PMID: 26337230) Liu Y … Zheng Y (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2015) 3 56

Products for MIR365B Gene

Sources for MIR365B Gene