microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR365A Gene

Subcategory (RNA class) for MIR365A Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR365A Gene

  • MicroRNA 365a 2 3 5
  • Hsa-MiR-365b-3p 163 173
  • Hsa-MiR-365a-5p 163 173
  • Hsa-MiR-365a-3p 163 173
  • MicroRNA 365-1 2 3
  • Hsa-Mir-365-1 2 3
  • MIR365A 2 5
  • Hsa-Mir-193-P2b 178
  • Hsa-Mir-365a 3
  • MIMAT0000710 50
  • MIMAT0022834 50
  • MIMAT0009199 50
  • MIRN365-1 3
  • MI0000767 50
  • MIR365-1 3
  • Mir-365a 3
  • RF00659 168

External Ids for MIR365A Gene

Previous HGNC Symbols for MIR365A Gene

  • MIRN365-1
  • MIR365-1

Previous GeneCards Identifiers for MIR365A Gene

  • GC16P014404
  • GC16P014405

Summaries for MIR365A Gene

Entrez Gene Summary for MIR365A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR365A Gene

MIR365A (MicroRNA 365a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR365A include Larynx Cancer and Laryngeal Disease.

Rfam classification for MIR365A Gene

Additional gene information for MIR365A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR365A Gene

Genomics for MIR365A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR365A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J014522 Enhancer 0.8 Ensembl ENCODE 11.6 +214.2 214216 4.6 IKZF1 ZSCAN4 CEBPA SCRT2 SOX13 FOXA2 TEAD1 ZGPAT CEBPB TEAD3 MIR365A MIR193B BFAR PARN ERCC4 RPS26P52 LOC100505915 NPIPA2 MIR193BHG LOC107984865
GH16J014300 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 -3.1 -3087 10.9 SP1 HNRNPL CREB1 GATAD2A CTCF ZBTB33 PRDM10 TFE3 IKZF1 NFKBIZ MIR193BHG PARN BFAR PDXDC1 NPIPP1 MRTFB AF480506-001 MIR193B MIR365A lnc-PARN-10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR365A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR365A Gene

Genomic Locations for MIR365A Gene
chr16:14,309,285-14,309,377
(GRCh38/hg38)
Size:
93 bases
Orientation:
Plus strand
chr16:14,403,142-14,403,228
(GRCh37/hg19)
Size:
87 bases
Orientation:
Plus strand

Genomic View for MIR365A Gene

Genes around MIR365A on UCSC Golden Path with GeneCards custom track
MIR365A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR365A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR365A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR365A Gene

Proteins for MIR365A Gene

Post-translational modifications for MIR365A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR365A Gene

Domains & Families for MIR365A Gene

Gene Families for MIR365A Gene

genes like me logo Genes that share domains with MIR365A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR365A Gene

Function for MIR365A Gene

Phenotypes From GWAS Catalog for MIR365A Gene

Gene Ontology (GO) - Molecular Function for MIR365A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 21518763
genes like me logo Genes that share ontologies with MIR365A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR365A Gene

Localization for MIR365A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR365A gene
Compartment Confidence
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR365A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR365A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR365A Gene

Pathways & Interactions for MIR365A Gene

PathCards logo

SuperPathways for MIR365A Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR365A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0035278 miRNA mediated inhibition of translation IDA 21518763
GO:0045409 negative regulation of interleukin-6 biosynthetic process IDA 30233734
genes like me logo Genes that share ontologies with MIR365A: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR365A Gene

Drugs & Compounds for MIR365A Gene

No Compound Related Data Available

Transcripts for MIR365A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR365A Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000031B6ED_9606 miRNA 23 6

RefSeq: NR_029854,

LncBase: hsa-miR-365a-5p,

miRBase: MIMAT0009199,

MirGeneDB: Hsa-Mir-193-P2b_5p,

TarBase: hsa-miR-365a-5p,

ENA: LM381142.1:1..23:ncRNA, LM608690.1:16..38:ncRNA,

URS00003E7283_9606 miRNA 22 6

RefSeq: NR_029854, NR_029856,

LncBase: hsa-miR-365a-3p, hsa-miR-365b-3p,

miRBase: MIMAT0000710, MIMAT0022834,

MirGeneDB: Hsa-Mir-193-P2a_3p,

TarBase: hsa-miR-365a-3p, hsa-miR-365b-3p,

ENA: AY882279.1:1..22:ncRNA, LM379224.1:1..22:ncRNA, LM383038.1:1..22:ncRNA, LM608690.1:56..77:ncRNA, LM608692.1:68..89:ncRNA,

URS000075A669_9606 precursor_RNA 87 5

HGNC: 33692,

RefSeq: NR_029854,

Ensembl: ENST00000362260 (view in UCSC) ,

miRBase: MI0000767,

ENA: LM608690.1:1..87:precursor_RNA,

URS000011554E_9606 precursor_RNA 93 1

Rfam: RF00659,

URS0000EFCCC1_9606 precursor_RNA 62 1

MirGeneDB: Hsa-Mir-193-P2b,

MIR365A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR365A Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR365A Gene

No ASD Table

Relevant External Links for MIR365A Gene

GeneLoc Exon Structure for
MIR365A

Expression for MIR365A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR365A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR365A

genes like me logo Genes that share expression patterns with MIR365A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR365A Gene

Orthologs for MIR365A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR365A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-365-1 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-365-1 31
  • 100 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-365-1 31
  • 99 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir365-1 31
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-365-1 31
  • 99 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-365 31
  • 98 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-365-1 31
  • 88 (a)
OneToOne
Species where no ortholog for MIR365A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR365A Gene

ENSEMBL:
Gene Tree for MIR365A (if available)
TreeFam:
Gene Tree for MIR365A (if available)

Paralogs for MIR365A Gene

No data available for Paralogs for MIR365A Gene

Variants for MIR365A Gene

Additional dbSNP identifiers (rs#s) for MIR365A Gene

Additional Variant Information for MIR365A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR365A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR365A Gene

Disorders for MIR365A Gene

MalaCards: The human disease database

(14) MalaCards diseases for MIR365A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
larynx cancer
  • laryngeal carcinoma
laryngeal disease
  • laryngeal diseases
spleen angiosarcoma
  • angiosarcoma of spleen
retinal vascular disease
  • retina circulation disorder
retinal cancer
  • malignant neoplasm of retina
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR365A

genes like me logo Genes that share disorders with MIR365A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR365A Gene

Publications for MIR365A Gene

  1. MiR-365 enhances the radiosensitivity of non-small cell lung cancer cells through targeting CDC25A. (PMID: 30902389) Li H … Fan S (Biochemical and biophysical research communications 2019) 3
  2. miR-365 inhibits cell invasion and migration of triple negative breast cancer through ADAM10. (PMID: 31786854) Liu F … Li D (Journal of B.U.ON. : official journal of the Balkan Union of Oncology 2019) 3
  3. A novel miR-365-3p/EHF/keratin 16 axis promotes oral squamous cell carcinoma metastasis, cancer stemness and drug resistance via enhancing β5-integrin/c-met signaling pathway. (PMID: 30782177) Huang WC … Wang LH (Journal of experimental & clinical cancer research : CR 2019) 3
  4. [Proliferation of MicroRNA-365 and E74-like Factor 4 in Cervical Cancer Cells and Its Clinical Significance]. (PMID: 31060678) Guo Y … Li O (Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2019) 3
  5. Altered expression of microRNA-365 is related to the occurrence and development of non-small-cell lung cancer by inhibiting TRIM25 expression. (PMID: 31099423) Han Q … Lin F (Journal of cellular physiology 2019) 3

Products for MIR365A Gene

Sources for MIR365A Gene