microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR3659 Gene

Subcategory (RNA class) for MIR3659 Gene

miRNA

Number of RNA Genes sources:

3 / 14

Aliases for MIR3659 Gene

  • MicroRNA 3659 2 3 5
  • Hsa-Mir-3659 3
  • Hsa-MiR-3659 177
  • MIMAT0018080 51
  • MI0016060 51
  • Mir-3659 3
  • MIR3659 2

External Ids for MIR3659 Gene

Previous GeneCards Identifiers for MIR3659 Gene

  • GC01U903124
  • GC01P038556

Summaries for MIR3659 Gene

Entrez Gene Summary for MIR3659 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3659 Gene

MIR3659 (MicroRNA 3659) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR3659 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR3659 Gene

Genomics for MIR3659 Gene

GeneHancer (GH) Regulatory Elements for MIR3659 Gene

Promoters and enhancers for MIR3659 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J038088 Enhancer 0.5 Ensembl 500.7 -0.6 -630 1.6 CTCF CTBP1 ZNF189 RAD21 KLF1 EGR2 ZNF600 MIR3659 MIR3659HG POU3F1 ENSG00000223589 lnc-POU3F1-4
GH01J038094 Enhancer 1.2 VISTA UCNEbase Ensembl 0.7 +4.7 4737 3.9 ZNF341 SMARCA5 BCOR PRDM6 FEZF1 ZMYM3 TRIM28 ZFP36 DACH1 EZH2 MIR3659HG POU3F1 MIR3659 RF00017-166
GH01J038084 Enhancer 0.5 Ensembl 0.7 -4.5 -4530 1 FOXA2 RAD21 RXRA HNF4A REST SP1 MIR3659HG POU3F1 ENSG00000223589 MIR3659 lnc-POU3F1-4
GH01J038085 Enhancer 0.4 Ensembl 0.7 -2.7 -2730 1.8 RBM25 BCOR ZMYM3 KDM1A ZNF770 MIR3659HG POU3F1 MIR3659 ENSG00000223589 lnc-POU3F1-4
GH01J038082 Enhancer 0.6 Ensembl 0.4 -6.0 -5967 1.7 ZIC2 REST ZBTB7A FOXA2 TRIM24 RXRA GLIS1 HNF4A SMARCA4 TFAP4 MIR3659HG POU3F1 ENSG00000223589 lnc-POU3F1-4 MIR3659
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR3659 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR3659 Gene

Genomic Locations for MIR3659 Gene
chr1:38,089,231-38,089,329
(GRCh38/hg38)
Size:
99 bases
Orientation:
Plus strand
chr1:38,554,903-38,555,001
(GRCh37/hg19)
Size:
99 bases
Orientation:
Plus strand

Genomic View for MIR3659 Gene

Genes around MIR3659 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3659 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3659 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3659 Gene

Proteins for MIR3659 Gene

Post-translational modifications for MIR3659 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3659 Gene

Domains & Families for MIR3659 Gene

Gene Families for MIR3659 Gene

HGNC:
genes like me logo Genes that share domains with MIR3659: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR3659 Gene

Function for MIR3659 Gene

Phenotypes From GWAS Catalog for MIR3659 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3659 Gene

Localization for MIR3659 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR3659 gene
Compartment Confidence
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR3659 Gene

Pathways & Interactions for MIR3659 Gene

PathCards logo

SuperPathways for MIR3659 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR3659 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR3659 Gene

Drugs & Compounds for MIR3659 Gene

No Compound Related Data Available

Transcripts for MIR3659 Gene

mRNA/cDNA for MIR3659 Gene

3 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 miRBase transcripts :
4 ENA transcripts :
1 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3659 Gene

No ASD Table

Relevant External Links for MIR3659 Gene

GeneLoc Exon Structure for
MIR3659

Expression for MIR3659 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR3659 Gene

genes like me logo Genes that share expression patterns with MIR3659: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR3659 Gene

Orthologs for MIR3659 Gene

Evolution for MIR3659 Gene

ENSEMBL:
Gene Tree for MIR3659 (if available)
TreeFam:
Gene Tree for MIR3659 (if available)

No data available for Orthologs for MIR3659 Gene

Paralogs for MIR3659 Gene

No data available for Paralogs for MIR3659 Gene

Variants for MIR3659 Gene

Additional dbSNP identifiers (rs#s) for MIR3659 Gene

Additional Variant Information for MIR3659 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3659

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR3659 Gene

Disorders for MIR3659 Gene

Additional Disease Information for MIR3659

No disorders were found for MIR3659 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3659 Gene

Publications for MIR3659 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 54
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 54
  3. Re-inspection of small RNA sequence datasets reveals several novel human miRNA genes. (PMID: 20532037) Hansen TB … Kjems J (PloS one 2010) 3 54
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 54

Products for MIR3659 Gene

Sources for MIR3659 Gene