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Aliases for MIR3649 Gene

Subcategory (RNA class) for MIR3649 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR3649 Gene

  • MicroRNA 3649 2 3 5
  • Hsa-Mir-3649 3

External Ids for MIR3649 Gene

Previous GeneCards Identifiers for MIR3649 Gene

  • GC12U901533
  • GC12M001774

Summaries for MIR3649 Gene

Entrez Gene Summary for MIR3649 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3649 Gene

MIR3649 (MicroRNA 3649) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR3649 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3649 Gene

Genomics for MIR3649 Gene

GeneHancer (GH) Regulatory Elements for MIR3649 Gene

Promoters and enhancers for MIR3649 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J001658 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 600.7 -0.9 -906 5.3 ZFX ELF3 MNT CBFA2T2 ZNF148 POLR2A ZNF121 CEBPG RERE ZSCAN21 MIR3649 RAD52 ADIPOR2 DCP1B CACNA2D4 ENSG00000256706 LRTM2 CACNA1C
GH12J001668 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 0.4 -9.8 -9844 3.6 ELF3 RERE ZNF384 TFE3 SP1 PPARG KAT8 HMG20B RXRA CREB1 CACNA2D4 ENSG00000256706 MIR3649 ADIPOR2
GH12J001628 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 0.3 +30.6 30601 2.4 SP1 CTCF EZH2 DPF2 POLR2A NR2F1 ZFHX2 RCOR1 WT1 HNF4A WNT5B ENSG00000256706 CACNA2D4 ERC1 ENSG00000250132 RAD52 LINC00940 MIR3649 FBXL14
GH12J001649 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +10.1 10079 3 ZNF24 ZNF316 CTBP1 MAFG NFIC NFE2 ZFP64 IKZF1 POLR2A ELF1 ADIPOR2 CACNA2D4 ENSG00000256706 MIR3649 FBXL14
GH12J001652 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 +7.5 7479 1.4 CTCF ZNF384 RAD21 REST TRIM22 RUNX3 USF1 DEK RFX5 SMC3 ADIPOR2 ENSG00000256706 CACNA2D4 MIR3649 FBXL14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR3649 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR3649 Gene

Genomic Locations for MIR3649 Gene
chr12:1,660,315-1,660,380
(GRCh38/hg38)
Size:
66 bases
Orientation:
Minus strand
chr12:1,769,481-1,769,546
(GRCh37/hg19)
Size:
66 bases
Orientation:
Minus strand

Genomic View for MIR3649 Gene

Genes around MIR3649 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3649 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3649 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3649 Gene

Proteins for MIR3649 Gene

Post-translational modifications for MIR3649 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3649 Gene

Domains & Families for MIR3649 Gene

Gene Families for MIR3649 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR3649: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR3649 Gene

Function for MIR3649 Gene

Phenotypes From GWAS Catalog for MIR3649 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3649 Gene

Localization for MIR3649 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR3649 Gene

Pathways & Interactions for MIR3649 Gene

PathCards logo

SuperPathways for MIR3649 Gene

No Data Available

Interacting Proteins for MIR3649 Gene

Gene Ontology (GO) - Biological Process for MIR3649 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR3649 Gene

Drugs & Compounds for MIR3649 Gene

No Compound Related Data Available

Transcripts for MIR3649 Gene

mRNA/cDNA for MIR3649 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNA Central transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3649 Gene

No ASD Table

Relevant External Links for MIR3649 Gene

GeneLoc Exon Structure for
MIR3649
ECgene alternative splicing isoforms for
MIR3649

Expression for MIR3649 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR3649 Gene:

MIR3649
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR3649 Gene

Orthologs for MIR3649 Gene

Evolution for MIR3649 Gene

ENSEMBL:
Gene Tree for MIR3649 (if available)
TreeFam:
Gene Tree for MIR3649 (if available)

No data available for Orthologs for MIR3649 Gene

Paralogs for MIR3649 Gene

No data available for Paralogs for MIR3649 Gene

Variants for MIR3649 Gene

Sequence variations from dbSNP and Humsavar for MIR3649 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000019051 -- 1,660,351(-) C/A/G non_coding_transcript_variant
rs1002436850 -- 1,660,478(-) T/C upstream_transcript_variant
rs1003916968 -- 1,661,060(-) G/A upstream_transcript_variant
rs1008373275 -- 1,661,838(-) CGGACTCGGA/CGGACTCGGACTCGGA upstream_transcript_variant
rs1008880076 -- 1,662,030(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR3649 Gene

Variant ID Type Subtype PubMed ID
nsv556995 CNV loss 21841781
nsv832304 CNV gain 17160897

Additional Variant Information for MIR3649 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3649

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR3649 Gene

Disorders for MIR3649 Gene

Additional Disease Information for MIR3649

No disorders were found for MIR3649 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3649 Gene

Publications for MIR3649 Gene

  1. Discovery of microRNAs and other small RNAs in solid tumors. (PMID: 20483914) Meiri E … Sitbon E (Nucleic acids research 2010) 3 58
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR3649 Gene

Sources for MIR3649 Gene

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