microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR363 Gene

Subcategory (RNA class) for MIR363 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR363 Gene

  • MicroRNA 363 2 3 5
  • Hsa-MiR-363-3p 163 173
  • Hsa-MiR-363-5p 163 173
  • Hsa-Mir-363 2 3
  • MIR-363 2 3
  • MIR363 2 5
  • Hsa-Mir-92-P2b 178
  • MIMAT0003385 50
  • MIMAT0000707 50
  • MI0000764 50
  • MIRN363 3
  • RF01898 168

External Ids for MIR363 Gene

Previous HGNC Symbols for MIR363 Gene

  • MIRN363

Previous GeneCards Identifiers for MIR363 Gene

  • GC0XM133150
  • GC0XM133157
  • GC0XM133303
  • GC0XM134170
  • GC0XM134220
  • GC0XM134226
  • GC0XM134234
  • GC0XM134214
  • GC0XM134187
  • GC0XM134193
  • GC0XM134199

Summaries for MIR363 Gene

Entrez Gene Summary for MIR363 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR363 Gene

MIR363 (MicroRNA 363) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR363 include Alzheimer Disease and Feingold Syndrome 1. Among its related pathways are Parkinsons Disease Pathway and MicroRNAs in cancer.

Rfam classification for MIR363 Gene

Additional gene information for MIR363 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR363 Gene

Genomics for MIR363 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR363 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ134169 Enhancer 0.2 Ensembl 600.7 -0.4 -441 0.2 MIR106A MIR18B MIR19B2 MIR20B MIR363 MIR92A2 ENSG00000283638 CCDC160 GPC3
GH0XJ134146 Enhancer 0.6 Ensembl 12.5 +22.8 22759 0.2 FOXA2 HHEX FOXP1 SMAD4 BCL6 RARA NR2F6 NR2F1 FOXA3 SP5 MIR363 RF00017-8728 piR-32285-104 CCDC160 GPC3
GH0XJ134148 Enhancer 0.4 FANTOM5 13.1 +20.9 20912 0.3 RFX1 ZBTB5 CC2D1A MIR363 RF00017-8728 piR-32285-104 CCDC160 GPC3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR363 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR363 Gene

Genomic Locations for MIR363 Gene
chrX:134,169,373-134,169,460
(GRCh38/hg38)
Size:
88 bases
Orientation:
Minus strand
chrX:133,303,408-133,303,482
(GRCh37/hg19)
Size:
75 bases
Orientation:
Minus strand

Genomic View for MIR363 Gene

Genes around MIR363 on UCSC Golden Path with GeneCards custom track
MIR363 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR363 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR363 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR363 Gene

Proteins for MIR363 Gene

Post-translational modifications for MIR363 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR363 Gene

Domains & Families for MIR363 Gene

Gene Families for MIR363 Gene

genes like me logo Genes that share domains with MIR363: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR363 Gene

Function for MIR363 Gene

Gene Ontology (GO) - Molecular Function for MIR363 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR363: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR363 Gene

Localization for MIR363 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR363 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR363 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR363: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR363 Gene

Pathways & Interactions for MIR363 Gene

PathCards logo

SuperPathways for MIR363 Gene

genes like me logo Genes that share pathways with MIR363: view

Pathways by source for MIR363 Gene

1 BioSystems pathway for MIR363 Gene
1 KEGG pathway for MIR363 Gene

Gene Ontology (GO) - Biological Process for MIR363 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 20190813
genes like me logo Genes that share ontologies with MIR363: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR363 Gene

Drugs & Compounds for MIR363 Gene

No Compound Related Data Available

Transcripts for MIR363 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR363 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000038B599_9606 miRNA 22 6

RefSeq: NR_029852,

LncBase: hsa-miR-363-3p,

miRBase: MIMAT0000707,

MirGeneDB: Hsa-Mir-92-P2b_3p,

TarBase: hsa-miR-363-3p,

ENA: AY785932.1:1..22:ncRNA, LM379222.1:1..22:ncRNA, LM608688.1:50..71:ncRNA,

URS000075E6A6_9606 precursor_RNA 75 5

HGNC: 32023,

RefSeq: NR_029852,

Ensembl: ENST00000384840 (view in UCSC) ,

miRBase: MI0000764,

ENA: LM608688.1:1..75:precursor_RNA,

URS00000B989F_9606 miRNA 22 5

RefSeq: NR_029852,

LncBase: hsa-miR-363-5p,

miRBase: MIMAT0003385,

TarBase: hsa-miR-363-5p,

ENA: LM379915.1:1..22:ncRNA, LM608688.1:7..28:ncRNA,

URS00006A7DD4_9606 precursor_RNA 88 1

Rfam: RF01898,

URS0000EFD29D_9606 precursor_RNA 66 1

MirGeneDB: Hsa-Mir-92-P2b,

MIR363 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR363 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR363 Gene

No ASD Table

Relevant External Links for MIR363 Gene

GeneLoc Exon Structure for
MIR363

Expression for MIR363 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR363

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR363 Gene

Orthologs for MIR363 Gene

Evolution for MIR363 Gene

ENSEMBL:
Gene Tree for MIR363 (if available)
TreeFam:
Gene Tree for MIR363 (if available)

No data available for Orthologs for MIR363 Gene

Paralogs for MIR363 Gene

No data available for Paralogs for MIR363 Gene

Variants for MIR363 Gene

Additional dbSNP identifiers (rs#s) for MIR363 Gene

Additional Variant Information for MIR363 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR363

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR363 Gene

Disorders for MIR363 Gene

MalaCards: The human disease database

(10) MalaCards diseases for MIR363 Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • ad
feingold syndrome 1
  • fglds1
pharynx cancer
  • pharyngeal cancer
nasopharyngeal disease
  • nasopharyngeal diseases
nasopharyngeal carcinoma
  • npc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR363

genes like me logo Genes that share disorders with MIR363: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR363 Gene

Publications for MIR363 Gene

  1. MicroRNA-363-3p/p21(Cip1/Waf1) axis is regulated by HIF-2α in mediating stemness of melanoma cells. (PMID: 30784290) Hao T … Xing XJ (Neoplasma 2019) 3
  2. DAB2IP Expression in Abdominal Aortic Aneurysm: EZH2 and mir-363-3p as Potential Mediators. (PMID: 31028191) Legaki E … Gazouli M (In vivo (Athens, Greece) 2019) 3
  3. MicroRNA‑363‑3p inhibits hepatocarcinogenesis by targeting HMGA2 and is associated with liver cancer stage. (PMID: 30535489) Wang J … Yuan Y (Molecular medicine reports 2019) 3
  4. MicroRNA-363-3p suppresses anoikis resistance in human papillary thyroid carcinoma via targeting integrin alpha 6. (PMID: 31257410) Pan Y … Chen Y (Acta biochimica et biophysica Sinica 2019) 3
  5. MicroRNA-363 inhibits angiogenesis, proliferation, invasion, and migration of renal cell carcinoma via inactivation of the Janus tyrosine kinases 2-signal transducers and activators of transcription 3 axis by suppressing growth hormone receptor gene. (PMID: 30229899) Zhu J … Zhang X (Journal of cellular physiology 2019) 3

Products for MIR363 Gene

Sources for MIR363 Gene