microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR3614 Gene

Data sources for MIR3614 Gene:

RNA type for MIR3614 Gene

miRNA

Aliases for MIR3614 Gene

External Ids for MIR3614 Gene

Previous GeneCards Identifiers for MIR3614 Gene

  • GC17U901561
  • GC17M054973

Summaries for MIR3614 Gene

Entrez Gene Summary for MIR3614 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3614 Gene

MIR3614 (MicroRNA 3614) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR3614 include Dengue Disease. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and DNA Double-Strand Break Repair.

Additional gene information for MIR3614 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR3614 Gene

Genomics for MIR3614 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR3614 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J056889 Enhancer 0.7 dbSUPER 250.7 +0.2 246 2.3 POLR2A CTCF REST ZBTB7B SIN3A CTBP1 RBM22 RAD21 DPF2 NCOA3 MIR3614 lnc-COIL-7 TRIM25 C17orf67 SCPEP1 ENSG00000262112 lnc-COIL-6-001 HSALNG0117599
GH17J056890 Enhancer 0.4 dbSUPER 250.7 +1.8 1804 0.5 CUX1 POLR2A HLF ENSG00000262112 MIR3614 lnc-COIL-7 C17orf67 SCPEP1 HSALNG0117599 TRIM25
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR3614 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR3614 Gene

Latest Assembly
chr17:56,891,270-56,891,355
(GRCh38/hg38)
Size:
86 bases
Orientation:
Minus strand

Previous Assembly
chr17:54,968,631-54,968,716
(GRCh37/hg19 by Entrez Gene)
Size:
86 bases
Orientation:
Minus strand

Genomic View for MIR3614 Gene

Genes around MIR3614 on UCSC Golden Path with GeneCards custom track
MIR3614 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR3614 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3614 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3614 Gene

Proteins for MIR3614 Gene

Post-translational modifications for MIR3614 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3614 Gene

Domains & Families for MIR3614 Gene

Gene Families for MIR3614 Gene

HGNC:
genes like me logo Genes that share domains with MIR3614: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR3614 Gene

Function for MIR3614 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3614 Gene

Localization for MIR3614 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR3614 gene
Compartment Confidence
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR3614 Gene

Pathways & Interactions for MIR3614 Gene

genes like me logo Genes that share pathways with MIR3614: view

Pathways by source for MIR3614 Gene

Gene Ontology (GO) - Biological Process for MIR3614 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR3614 Gene

Drugs & Compounds for MIR3614 Gene

No Compound Related Data Available

Transcripts for MIR3614 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR3614 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00003D4175_9606 miRNA 23 5

RefSeq: NR_037408,

LncBase: hsa-miR-3614-5p,

miRBase: MIMAT0017992,

TarBase: hsa-miR-3614-5p,

ENA: LM382139.1:1..23:ncRNA, LM611173.1:15..37:ncRNA,

URS000075E293_9606 precursor_RNA 86 4

RefSeq: NR_037408,

Ensembl: ENST00000581261 (view in UCSC) ,

miRBase: MI0016004,

ENA: LM611173.1:1..86:precursor_RNA,

URS000042BE4B_9606 miRNA 23 4

RefSeq: NR_037408,

miRBase: MIMAT0017993,

TarBase: hsa-miR-3614-3p,

ENA: LM382140.1:1..23:ncRNA, LM611173.1:53..75:ncRNA,

URS0000054224_9606 miRNA 22 1

ENA: FR772789.1:1..22:ncRNA,

URS00000D5E06_9606 miRNA 22 1

ENA: FR772788.1:1..22:ncRNA,

MIR3614 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR3614 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3614 Gene

No ASD Table

Relevant External Links for MIR3614 Gene

GeneLoc Exon Structure for
MIR3614

Expression for MIR3614 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR3614 Gene

mRNA differential expression in normal tissues according to GTEx for MIR3614 Gene

This gene is overexpressed in Whole Blood (x11.4).
genes like me logo Genes that share expression patterns with MIR3614: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR3614 Gene

Orthologs for MIR3614 Gene

Evolution for MIR3614 Gene

ENSEMBL:
Gene Tree for MIR3614 (if available)
TreeFam:
Gene Tree for MIR3614 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR3614

No data available for Orthologs for MIR3614 Gene

Paralogs for MIR3614 Gene

No data available for Paralogs for MIR3614 Gene

Variants for MIR3614 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR3614 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR3614 Gene

Variant ID Type Subtype PubMed ID
esv32884 CNV loss 17666407

Additional Variant Information for MIR3614 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3614
Leiden Open Variation Database (LOVD)
MIR3614

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR3614 Gene

Disorders for MIR3614 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR3614 Gene - From: COP

Disorder Aliases PubMed IDs
dengue disease
  • breakbone fever
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR3614

genes like me logo Genes that share disorders with MIR3614: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR3614 Gene

Publications for MIR3614 Gene

  1. Blockade of miR-3614 maturation by IGF2BP3 increases TRIM25 expression and promotes breast cancer cell proliferation. (PMID: 30797711) Wang Z … Huang C (EBioMedicine 2019) 3
  2. Evidence for a potential role of miR-1908-5p and miR-3614-5p in autoimmune disease risk using integrative bioinformatics. (PMID: 30143393) Wohlers I … Lill CM (Journal of autoimmunity 2018) 3
  3. MicroRNA profiling of human primary macrophages exposed to dengue virus identifies miRNA-3614-5p as antiviral and regulator of ADAR1 expression. (PMID: 29045406) Diosa-Toro M … Smit JM (PLoS neglected tropical diseases 2017) 3
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  5. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3

Products for MIR3614 Gene

Sources for MIR3614 Gene