microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR3606 Gene

Data sources for MIR3606 Gene:

RNA type for MIR3606 Gene

miRNA

Aliases for MIR3606 Gene

External Ids for MIR3606 Gene

Previous GeneCards Identifiers for MIR3606 Gene

  • GC02U902314
  • GC02P189862

Summaries for MIR3606 Gene

Entrez Gene Summary for MIR3606 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3606 Gene

MIR3606 (MicroRNA 3606) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Degradation of the extracellular matrix and Collagen chain trimerization.

Additional gene information for MIR3606 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR3606 Gene

Genomics for MIR3606 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR3606 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J188995 Enhancer 0.6 Ensembl ENCODE 250.7 +1.1 1077 2.2 MAFK POLR2A HLF HSALNG0021028 MIR3606 HSALNG0021030 COL3A1 NONHSAG030072.2 COL5A2
GH02J189002 Enhancer 0.7 Ensembl ENCODE 0.4 +6.7 6675 2.6 JUND EP300 CUX1 MAFK CREB1 POLR2A NFE2L2 FOS MIR1245A HSALNG0021030 MIR3606 COL3A1 NONHSAG030072.2 COL5A2
GH02J188999 Enhancer 0.2 Ensembl 0.7 +3.7 3671 0.2 MIR1245A MIR3606 HSALNG0021030 COL3A1 NONHSAG030072.2 COL5A2
GH02J189000 Enhancer 0.2 Ensembl 0.7 +4.9 4871 0.2 MIR1245A MIR3606 HSALNG0021030 COL3A1 NONHSAG030072.2 COL5A2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR3606 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR3606 Gene

Latest Assembly
chr2:188,995,630-188,995,692
(GRCh38/hg38)
Size:
63 bases
Orientation:
Plus strand

Previous Assembly
chr2:189,860,356-189,860,418
(GRCh37/hg19 by Entrez Gene)
Size:
63 bases
Orientation:
Plus strand

Genomic View for MIR3606 Gene

Genes around MIR3606 on UCSC Golden Path with GeneCards custom track
MIR3606 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR3606 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3606 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3606 Gene

Proteins for MIR3606 Gene

Post-translational modifications for MIR3606 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3606 Gene

Domains & Families for MIR3606 Gene

Gene Families for MIR3606 Gene

HGNC:
genes like me logo Genes that share domains with MIR3606: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR3606 Gene

Function for MIR3606 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3606 Gene

Localization for MIR3606 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR3606 Gene

Pathways & Interactions for MIR3606 Gene

genes like me logo Genes that share pathways with MIR3606: view

Gene Ontology (GO) - Biological Process for MIR3606 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR3606 Gene

Drugs & Compounds for MIR3606 Gene

No Compound Related Data Available

Transcripts for MIR3606 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR3606 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000075D9F9_9606 pre_miRNA 63 4

RefSeq: NR_037401,

Ensembl: ENST00000637672 (view in UCSC) ,

miRBase: MI0015996,

ENA: LM611167.1:1..63:precursor_RNA,

URS00003AFAD1_9606 miRNA 21 3

RefSeq: NR_037401,

miRBase: MIMAT0017983,

ENA: LM382131.1:1..21:ncRNA, LM611167.1:16..36:ncRNA,

URS000075D027_9606 miRNA 21 3

RefSeq: NR_037401,

miRBase: MIMAT0022965,

ENA: LM611167.1:42..62:ncRNA,

MIR3606 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR3606 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3606 Gene

No ASD Table

Relevant External Links for MIR3606 Gene

GeneLoc Exon Structure for
MIR3606

Expression for MIR3606 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR3606 Gene

Orthologs for MIR3606 Gene

Evolution for MIR3606 Gene

ENSEMBL:
Gene Tree for MIR3606 (if available)
TreeFam:
Gene Tree for MIR3606 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR3606

No data available for Orthologs for MIR3606 Gene

Paralogs for MIR3606 Gene

No data available for Paralogs for MIR3606 Gene

Variants for MIR3606 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR3606 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
101134 Pathogenic: Ehlers-Danlos syndrome, type 4 188,994,960(+) ATGACATAAAAATATT
NM_000090.3(COL3A1):c.1455+133_1978-178del (p.Gly486_Pro659del)
SPLICE_ACCEPTOR_VARIANT,SPLICE_DONOR
974723 Uncertain Significance: Aganglionic megacolon 188,984,270(+) TTATGCTGCCAAGATT
NM_000090.4(COL3A1):c.80-489_3525+120del
SPLICE_ACCEPTOR_VARIANT,SPLICE_DONOR
rs1057520926 Likely Benign: not specified 188,995,674(+) A/G
NM_000090.3(COL3A1):c.1510-18A>G
NON_CODING_TRANSCRIPT
rs982619356 Uncertain Significance: not provided 188,995,684(+) C/A
NM_000090.3(COL3A1):c.1510-8C>A
NON_CODING_TRANSCRIPT

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR3606 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR3606 Gene

Variant ID Type Subtype PubMed ID
dgv7234n54 CNV loss 21841781

Additional Variant Information for MIR3606 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3606
Leiden Open Variation Database (LOVD)
MIR3606

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR3606 Gene

Disorders for MIR3606 Gene

Additional Disease Information for MIR3606

No disorders were found for MIR3606 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3606 Gene

Publications for MIR3606 Gene

  1. MiR-3606-3p inhibits systemic sclerosis through targeting TGF-β type II receptor. (PMID: 30145936) Shi X … Wang J (Cell cycle (Georgetown, Tex.) 2018) 3
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  3. Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls. (PMID: 20459774) Witten D … Lui WO (BMC biology 2010) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR3606 Gene

Sources for MIR3606 Gene