microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR3605 Gene

Data sources for MIR3605 Gene:

RNA type for MIR3605 Gene

miRNA

Aliases for MIR3605 Gene

External Ids for MIR3605 Gene

Previous GeneCards Identifiers for MIR3605 Gene

  • GC01U903130
  • GC01M033801
  • GC01M033804

Summaries for MIR3605 Gene

Entrez Gene Summary for MIR3605 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3605 Gene

MIR3605 (MicroRNA 3605) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR3605 include Multiple System Atrophy 1. Among its related pathways are SUMOylation and Cellular Senescence (REACTOME).

Additional gene information for MIR3605 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR3605 Gene

Genomics for MIR3605 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR3605 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J033330 Enhancer 0.9 ENCODE dbSUPER 250.7 -0.3 -345 5.6 SSRP1 YY1 RXRA SMAD4 SAP130 RARA TEAD3 THRB RBM22 JUND MIR3605 PHC2 A3GALT2 ENSG00000225313 TRIM62 HSALNG0002396 RN7SKP16 lnc-A3GALT2-5
GH01J033327 Enhancer 0.7 ENCODE dbSUPER 0.7 +4.1 4052 2.8 JUND CTCF RBM22 SPI1 ZNF362 BHLHE40 CEBPB POLR2A RFX1 FOS A3GALT2 PHC2 lnc-A3GALT2-4 MIR3605 ENSG00000225313
GH01J033336 Enhancer 0.4 dbSUPER 0.7 -4.2 -4196 0.8 JUND RBM22 FOS HSALNG0002396 RN7SKP16 lnc-A3GALT2-5 ENSG00000225313 PHC2 TRIM62 A3GALT2 MIR3605
GH01J033323 Enhancer 0.5 Ensembl dbSUPER 0.4 +7.5 7491 1.6 ZIC2 RBM22 lnc-A3GALT2-4 A3GALT2 MIR3605 ENSG00000225313 PHC2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR3605 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR3605 Gene

Latest Assembly
chr1:33,332,393-33,332,492
(GRCh38/hg38)
Size:
100 bases
Orientation:
Minus strand

Previous Assembly
chr1:33,797,994-33,798,093
(GRCh37/hg19 by Entrez Gene)
Size:
100 bases
Orientation:
Minus strand

Genomic View for MIR3605 Gene

Genes around MIR3605 on UCSC Golden Path with GeneCards custom track
MIR3605 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR3605 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3605 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3605 Gene

Proteins for MIR3605 Gene

Post-translational modifications for MIR3605 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3605 Gene

Domains & Families for MIR3605 Gene

Gene Families for MIR3605 Gene

HGNC:
genes like me logo Genes that share domains with MIR3605: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR3605 Gene

Function for MIR3605 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3605 Gene

Localization for MIR3605 Gene

Gene Ontology (GO) - Cellular Components for MIR3605 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR3605: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR3605 Gene

Pathways & Interactions for MIR3605 Gene

genes like me logo Genes that share pathways with MIR3605: view

Gene Ontology (GO) - Biological Process for MIR3605 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR3605 Gene

Drugs & Compounds for MIR3605 Gene

No Compound Related Data Available

Transcripts for MIR3605 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR3605 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00000A9FB9_9606 miRNA 23 5

RefSeq: NR_037400,

LncBase: hsa-miR-3605-3p,

miRBase: MIMAT0017982,

TarBase: hsa-miR-3605-3p,

ENA: LM382130.1:1..23:ncRNA, LM611166.1:66..88:ncRNA,

URS000018C677_9606 miRNA 23 5

RefSeq: NR_037400,

LncBase: hsa-miR-3605-5p,

miRBase: MIMAT0017981,

TarBase: hsa-miR-3605-5p,

ENA: LM382129.1:1..23:ncRNA, LM611166.1:22..44:ncRNA,

URS000075BFBA_9606 precursor_RNA 100 4

RefSeq: NR_037400,

Ensembl: ENST00000583214 (view in UCSC) ,

miRBase: MI0015995,

ENA: LM611166.1:1..100:precursor_RNA,

MIR3605 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR3605 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3605 Gene

No ASD Table

Relevant External Links for MIR3605 Gene

GeneLoc Exon Structure for
MIR3605

Expression for MIR3605 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR3605 Gene

mRNA differential expression in normal tissues according to GTEx for MIR3605 Gene

This gene is overexpressed in Whole Blood (x12.1).
genes like me logo Genes that share expression patterns with MIR3605: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR3605 Gene

Orthologs for MIR3605 Gene

Evolution for MIR3605 Gene

ENSEMBL:
Gene Tree for MIR3605 (if available)
TreeFam:
Gene Tree for MIR3605 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR3605

No data available for Orthologs for MIR3605 Gene

Paralogs for MIR3605 Gene

No data available for Paralogs for MIR3605 Gene

Variants for MIR3605 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR3605 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR3605 Gene

Variant ID Type Subtype PubMed ID
nsv516693 CNV loss 19592680
nsv522364 CNV loss 19592680
nsv545963 CNV loss 21841781

Additional Variant Information for MIR3605 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3605
Leiden Open Variation Database (LOVD)
MIR3605

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR3605 Gene

Disorders for MIR3605 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR3605 Gene - From: COP

Disorder Aliases PubMed IDs
multiple system atrophy 1
  • multiple system atrophy 1, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR3605

genes like me logo Genes that share disorders with MIR3605: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR3605 Gene

Publications for MIR3605 Gene

  1. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  3. Discovery of novel microRNAs in female reproductive tract using next generation sequencing. (PMID: 20224791) Creighton CJ … Gunaratne PH (PloS one 2010) 3
  4. Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls. (PMID: 20459774) Witten D … Lui WO (BMC biology 2010) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR3605 Gene

Sources for MIR3605 Gene