microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR3591 Gene

Subcategory (RNA class) for MIR3591 Gene

miRNA

Number of RNA Genes sources:

3 / 17

Aliases for MIR3591 Gene

  • MicroRNA 3591 2 3 5
  • Hsa-Mir-122b 2 3
  • Hsa-Mir-3591 2 3
  • MIR3591 2 5
  • Hsa-Mir-122-As 178
  • MIMAT0019876 50
  • MIMAT0019877 50
  • MI0017383 50

External Ids for MIR3591 Gene

Previous GeneCards Identifiers for MIR3591 Gene

  • GC18U900662
  • GC18M056121

Summaries for MIR3591 Gene

Entrez Gene Summary for MIR3591 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3591 Gene

MIR3591 (MicroRNA 3591) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are DNA Damage Response and Cell Differentiation - Index.

Rfam classification for MIR3591 Gene

  • mir-122 microRNA precursor

Additional gene information for MIR3591 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR3591 Gene

Genomics for MIR3591 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR3591 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR3591 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR3591 Gene

Genomic Locations for MIR3591 Gene
chr18:58,451,080-58,451,152
(GRCh38/hg38)
Size:
73 bases
Orientation:
Minus strand
chr18:56,118,312-56,118,384
(GRCh37/hg19)
Size:
73 bases
Orientation:
Minus strand

Genomic View for MIR3591 Gene

Genes around MIR3591 on UCSC Golden Path with GeneCards custom track
MIR3591 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR3591 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3591 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3591 Gene

Proteins for MIR3591 Gene

Post-translational modifications for MIR3591 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3591 Gene

Domains & Families for MIR3591 Gene

Gene Families for MIR3591 Gene

HGNC:
genes like me logo Genes that share domains with MIR3591: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR3591 Gene

Function for MIR3591 Gene

Phenotypes From GWAS Catalog for MIR3591 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3591 Gene

Localization for MIR3591 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR3591 Gene

Pathways & Interactions for MIR3591 Gene

PathCards logo

SuperPathways for MIR3591 Gene

genes like me logo Genes that share pathways with MIR3591: view

Pathways by source for MIR3591 Gene

Gene Ontology (GO) - Biological Process for MIR3591 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR3591: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR3591 Gene

Drugs & Compounds for MIR3591 Gene

No Compound Related Data Available

Transcripts for MIR3591 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR3591 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075BB45_9606 precursor_RNA 73 4

HGNC: 41875,

RefSeq: NR_039899,

Ensembl: ENST00000636727 (view in UCSC) ,

miRBase: MI0017383,

URS000052829C_9606 miRNA 23 3

RefSeq: NR_039899,

miRBase: MIMAT0019876,

ENA: FR772787.1:1..23:ncRNA,

URS000060BAA7_9606 miRNA 22 3

RefSeq: NR_039899,

miRBase: MIMAT0019877,

ENA: FR772786.1:1..22:ncRNA,

URS0000EFDD71_9606 precursor_RNA 59 1

MirGeneDB: Hsa-Mir-122-as,

URS0000D4FE6E_9606 miRNA 22 1

MirGeneDB: Hsa-Mir-122-as_5p,

MIR3591 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3591 Gene

No ASD Table

Relevant External Links for MIR3591 Gene

GeneLoc Exon Structure for
MIR3591

No data available for mRNA/cDNA for MIR3591 Gene

Expression for MIR3591 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR3591 Gene

genes like me logo Genes that share expression patterns with MIR3591: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR3591 Gene

Orthologs for MIR3591 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR3591 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-122 31
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-122 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-122 31
  • 98 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir122a 31
  • 97 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-122 31
  • 93 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-122 31
  • 68 (a)
OneToOne
Chicken
(Gallus gallus)
Aves gga-mir-122-1 31
  • 96 (a)
OneToMany
gga-mir-122-2 31
  • 95 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia aca-mir-122 31
  • 71 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii dre-mir-122 31
  • 84 (a)
OneToOne
Species where no ortholog for MIR3591 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIR3591 Gene

ENSEMBL:
Gene Tree for MIR3591 (if available)
TreeFam:
Gene Tree for MIR3591 (if available)

Paralogs for MIR3591 Gene

No data available for Paralogs for MIR3591 Gene

Variants for MIR3591 Gene

Additional dbSNP identifiers (rs#s) for MIR3591 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR3591 Gene

Variant ID Type Subtype PubMed ID
dgv3364n100 CNV gain 25217958

Additional Variant Information for MIR3591 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3591

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR3591 Gene

Disorders for MIR3591 Gene

Additional Disease Information for MIR3591

No disorders were found for MIR3591 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3591 Gene

Publications for MIR3591 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR3591 Gene

Sources for MIR3591 Gene